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Vincent A. Fischetti


Ph.D., Department of Microbiology, New York University, NY, 1970

Current position

Professor and Head, Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, USA

Publications (since 2009)

  1. Schuch, R., Lee, H. M., Schneider, B. C., Sauve, K. L., Law, C., Khan, B. K., Rotolo, J. A., Horiuchi, Y., Couto, D. E., Raz, A., Fischetti, V. A., Huang, D. B., Nowinski, R. C. and Wittekind, M. (2014). Combination therapy with lysin CF-301 and antibiotic is superior to antibiotic alone for treating methicillin-resistant Staphylococcus aureus-induced murine bacteremia. J Infect Dis 209(9): 1469-1478.
  2. Xu, Y., Brenning, B., Clifford, A., Vollmer, D., Bearss, J., Jones, C., McCarthy, V., Aavula, B., Warner, S., Bearss, D. J., McCullar, M. V., Schuch, R., Pelzek, A., Stebbins, C. E., Goldberg, A. R., Fischetti, V. A. and Vankayalapati, H. (2014). Discovery of Novel Inhibitors of 2-Epimerase as Potent Antibacterial Agents with Potent Gram-Positive Activity. ACS Med Chem Lett. 12;4(12):1142-1147.
  3. Lood, R., Raz, A., Molina, H., Euler, C. W. and Fischetti, V. A. (2014). A highly active and negatively charged Streptococcus pyogenes lysin with a rare D-alanyl-L-alanine endopeptidase activity protects mice against streptococcal bacteremia. Antimicrob Agents Chemother 58(6): 3073-3084.
  4. Utter, B., Deutsch, D. R., Schuch, R., Winer, B. Y., Verratti, K., Bishop-Lilly, K., Sozhamannan, S. and Fischetti, V. A. (2014). Beyond the chromosome: the prevalence of unique extra-chromosomal bacteriophages with integrated virulence genes in pathogenic Staphylococcus aureus. PLoS One 9(6): e100502.
  5. Schuch, R., Pelzek, A. J., Fazzini, M. M., Nelson, D. C. and Fischetti, V. A. (2014). Complete Genome Sequence of Bacillus cereus Sensu Lato Bacteriophage Bcp1. Genome Announc 2(3).
  6. Gilmer, D. B., Schmitz, J. E., Euler, C. W. and Fischetti, V. A. (2013). Novel bacteriophage lysin with broad lytic activity protects against mixed infection by Streptococcus pyogenes and methicillin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy 57(6): 2743-2750.
  7. Schuch, R., Pelzek, A. J., Raz, A., Euler, C. W., Ryan, P. A., Winer, B. Y., Farnsworth, A., Bhaskaran, S. S., Stebbins, C. E., Xu, Y., Clifford, A., Bearss, D. J., Vankayalapati, H., Goldberg, A. R. and Fischetti, V. A. (2013). Use of a bacteriophage lysin to identify a novel target for antimicrobial development. PLoS One 8(4): e60754.
  8. Dale, J. B., Fischetti, V. A., Carapetis, J. R., Steer, A. C., Sow, S., Kumar, R., Mayosi, B. M., Rubin, F. A., Mulholland, K., Hombach, J. M., Schodel, F. and Henao-Restrepo, A. M. (2013). Group A streptococcal vaccines: paving a path for accelerated development. Vaccine 31 Suppl 2: B216-222.
  9. Mujtaba, S., Winer, B. Y., Jaganathan, A., Patel, J., Sgobba, M., Schuch, R., Gupta, Y. K., Haider, S., Wang, R. and Fischetti, V. A. (2013). Anthrax SET protein: a potential virulence determinant that epigenetically represses NF-kappaB activation in infected macrophages. J Biol Chem 288(32): 23458-23472.
  10. Doehn, J. M., Fischer, K., Reppe, K., Gutbier, B., Tschernig, T., Hocke, A. C., Fischetti, V. A., Loffler, J., Suttorp, N., Hippenstiel, S. and Witzenrath, M. (2013). Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia. J Antimicrob Chemother 68(9): 2111-2117.
  11. Dhingra, N., Suarez-Farinas, M., Fuentes-Duculan, J., Gittler, J. K., Shemer, A., Raz, A., Fischetti, V. A., Krueger, J. G. and Guttman-Yassky, E. (2013). Attenuated neutrophil axis in atopic dermatitis compared to psoriasis reflects TH17 pathway differences between these diseases. J Allergy Clin Immunol 132(2): 498-501 e493.
  12. Pastagia, M., Schuch, R., Fischetti, V. A. and Huang, D. B. (2013). Lysins: the arrival of pathogen-directed anti-infectives. J Med Microbiol 62(Pt 10): 1506-1516.
  13. Kan, S., Fornelos, N., Schuch, R. and Fischetti, V. A. (2013). Identification of a ligand on the Wip1 bacteriophage highly specific for a receptor on Bacillus anthracis. J Bacteriol 195(19): 4355-4364.
  14. Vouillamoz, J., Entenza, J. M., Giddey, M., Fischetti, V. A., Moreillon, P. and Resch, G. (2013). Bactericidal synergism between daptomycin and the phage lysin Cpl-1 in a mouse model of pneumococcal bacteraemia. Int J Antimicrob Agents 42(5): 416-421.
  15. Rumah, K. R., Linden, J., Fischetti, V. A. and Vartanian, T. (2013). Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease. PLoS One 8(10): e76359.
  16. Ohkuni, H., Nagamune, H., Ozaki, N., Tabata, A., Todome, Y., Watanabe, Y., Takahashi, H., Ohkura, K., Kourai, H., Ohtsuka, H., Fischetti, V. A. and Zabriskie, J. B. (2012). Characterization of recombinant Streptococcus mitis-derived human platelet aggregation factor. APMIS 120(1): 56-71.
  17. Raz, A., Talay, S. R. and Fischetti, V. A. (2012). Cellular aspects of the distinct M protein and SfbI anchoring pathways in Streptococcus pyogenes. Mol Microbiol 84(4): 631-647.
  18. McGowan, S., Buckle, A. M., Mitchell, M. S., Hoopes, J. T., Gallagher, D. T., Heselpoth, R. D., Shen, Y., Reboul, C. F., Law, R. H., Fischetti, V. A., Whisstock, J. C. and Nelson, D. C. (2012). X-ray crystal structure of the streptococcal specific phage lysin PlyC. Proc Natl Acad Sci U S A 109(31): 12752-12757.
  19. Aksyuk, A. A., Bowman, V. D., Kaufmann, B., Fields, C., Klose, T., Holdaway, H. A., Fischetti, V. A. and Rossmann, M. G. (2012). Structural investigations of a Podoviridae streptococcus phage C1, implications for the mechanism of viral entry. Proc Natl Acad Sci U S A 109(35): 14001-14006.
  20. Pastagia, M., Euler, C., Chahales, P., Fuentes-Duculan, J., Krueger, J. G. and Fischetti, V. A. (2011). A novel chimeric lysin shows superiority to mupirocin for skin decolonization of methicillin-resistant and -sensitive Staphylococcus aureus strains. Antimicrob Agents Chemother 55(2): 738-744.
  21. Schmitz, J. E., Schuch, R. and Fischetti, V. A. (2010). Identifying active phage lysins through functional viral metagenomics. Applied and environmental microbiology 76(21): 7181-7187.
  22. Schmitz, J. E., Ossiprandi, M. C., Rumah, K. R. and Fischetti, V. A. (2011). Lytic enzyme discovery through multigenomic sequence analysis in Clostridium perfringens. Appl Microbiol Biotechnol 89(6): 1783-1795.
  23. Resch, G., Moreillon, P. and Fischetti, V. A. (2011). A stable phage lysin (Cpl-1) dimer with increased antipneumococcal activity and decreased plasma clearance. Int J Antimicrob Agents 38(6): 516-521.
  24. Resch, G., Moreillon, P. and Fischetti, V. A. (2011). PEGylating a bacteriophage endolysin inhibits its bactericidal activity. AMB Express 1: 29.
  25. Schuch, R., Pelzek, A. J., Kan, S. and Fischetti, V. A. (2010). Prevalence of Bacillus anthracis-like organisms and bacteriophages in the intestinal tract of the earthworm Eisenia fetida. Appl Environ Microbiol 76(7): 2286-2294.
  26. Daniel, A., Euler, C., Collin, M., Chahales, P., Gorelick, K. J. and Fischetti, V. A. (2010). Synergism between a novel chimeric lysin and oxacillin protects against infection by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 54(4): 1603-1612.
  27. Fazzini, M. M., Schuch, R. and Fischetti, V. A. (2010). A novel spore protein, ExsM, regulates formation of the exosporium in Bacillus cereus and Bacillus anthracis and affects spore size and shape. J Bacteriol 192(15): 4012-4021.
  28. Fischetti, V. A. (2010). Bacteriophage endolysins: a novel anti-infective to control Gram-positive pathogens. Int J Med Microbiol 300(6): 357-362.
  29. Witzenrath, M., Schmeck, B., Doehn, J. M., Tschernig, T., Zahlten, J., Loeffler, J. M., Zemlin, M., Muller, H., Gutbier, B., Schutte, H., Hippenstiel, S., Fischetti, V. A., Suttorp, N. and Rosseau, S. (2009). Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia. Crit Care Med 37(2): 642-649.
  30. Schuch, R. and Fischetti, V. A. (2009). The secret life of the anthrax agent Bacillus anthracis: bacteriophage-mediated ecological adaptations. PLoS One 4(8): e6532.
  31. Schuch, R., Fischetti, V. A. and Nelson, D. C. (2009). A genetic screen to identify bacteriophage lysins. Methods Mol Biol 502: 307-319.
  32. Fischetti, V. A. (2010). Bacteriophage endolysins: a novel anti-infective to control Gram-positive pathogens. Int J Med Microbiol 300(6): 357-362.
  33. Raz, A. and Fischetti, V. A. (2008). Sortase A localizes to distinct foci on the Streptococcus pyogenes membrane. Proc Natl Acad Sci U S A 105(47): 18549-18554.
  34. Fischetti, V. A. (2008). Bacteriophage lysins as effective antibacterials. Curr Opin Microbiol 11(5): 393-400.
Protocols by Vincent A. Fischetti
  1. Activity Assays for Bacteriophage Endolysin PlyPy