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Philippe J. Sansonetti


M.D., Faculty of Medicine, Paris, France, 1979
Certified in Internal Medicine, 1985
Certified in Clinical Microbiology, 1979

Current position

Professeur titulaire, Chaire de Microbiologie et Maladies Infectieuses, Collège de France, Paris, France
Professeur “classe exceptionnelle”, Head “Unité de Pathogénie Microbienne Moléculaire & Unité INSERM 786”, Institut Pasteur, Paris, France

Publications (since 2009)

  1. Mounier, J., Popoff, M. R., Enninga, J., Frame, M. C., Sansonetti, P. J. and Van Nhieu, G. T. (2009). The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells. PLoS Pathog 5(1): e1000271.
  2. Launay, O., Sadorge, C., Jolly, N., Poirier, B., Béchet, S., van der Vliet, D., Seffer, V., Fenner, N., Dowling, K. and Giemza, R. (2009). Safety and immunogenicity of SC599, an oral live attenuated Shigella dysenteriae type-1 vaccine in healthy volunteers: Results of a Phase 2, randomized, double-blind placebo-controlled trial. Vaccine 27(8): 1184-1191.
  3. Carneiro, L. A., Travassos, L. H., Soares, F., Tattoli, I., Magalhaes, J. G., Bozza, M. T., Plotkowski, M. C., Sansonetti, P. J., Molkentin, J. D., Philpott, D. J. and Girardin, S. E. (2009). Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe 5(2): 123-136.
  4. Phalipon, A., Tanguy, M., Grandjean, C., Guerreiro, C., Belot, F., Cohen, D., Sansonetti, P. J. and Mulard, L. A. (2009). A synthetic carbohydrate-protein conjugate vaccine candidate against Shigella flexneri 2a infection. J Immunol 182(4): 2241-2247.
  5. Viklund, I. M., Aspenstrom, P., Meas-Yedid, V., Zhang, B., Kopec, J., Agren, D., Schneider, G., D'Amato, M., Olivo-Marin, J. C., Sansonetti, P., Van Nhieu, G. T. and Pettersson, S. (2009). WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics. Exp Cell Res 315(6): 1040-1052.
  6. Bhattacharya, S., Black, R., Bourgeois, L., Clemens, J., Cravioto, A., Deen, J. L., Dougan, G., Glass, R., Grais, R. F., Greco, M., Gust, I., Holmgren, J., Kariuki, S., Lambert, P. H., Liu, M. A., Longini, I., Nair, G. B., Norrby, R., Nossal, G. J., Ogra, P., Sansonetti, P., von Seidlein, L., Songane, F., Svennerholm, A. M., Steele, D. and Walker, R. (2009). Public health. The cholera crisis in Africa. Science 324(5929): 885.
  7. Ray, K., Marteyn, B., Sansonetti, P. J. and Tang, C. M. (2009). Life on the inside: the intracellular lifestyle of cytosolic bacteria. Nat Rev Microbiol 7(5): 333-340.
  8. Sansonetti, P. J. (2009). Framing a concept and an agenda for infectious diseases in EMBO Molecular Medicine. EMBO Mol Med 1(4): 193-194.
  9. Dupont, N., Lacas-Gervais, S., Bertout, J., Paz, I., Freche, B., Van Nhieu, G. T., van der Goot, F. G., Sansonetti, P. J. and Lafont, F. (2009). Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe 6(2): 137-149.
  10. Sansonetti, P. J. and Medzhitov, R. (2009). Learning tolerance while fighting ignorance. Cell 138(3): 416-420.
  11. Bielig, H., Zurek, B., Kutsch, A., Menning, M., Philpott, D. J., Sansonetti, P. J. and Kufer, T. A. (2009). A function for AAMP in Nod2-mediated NF-kappaB activation. Mol Immunol 46(13): 2647-2654.
  12. Boullier, S., Tanguy, M., Kadaoui, K. A., Caubet, C., Sansonetti, P., Corthesy, B. and Phalipon, A. (2009). Secretory IgA-mediated neutralization of Shigella flexneri prevents intestinal tissue destruction by down-regulating inflammatory circuits. J Immunol 183(9): 5879-5885.
  13. Coron, E., Flamant, M., Aubert, P., Wedel, T., Pedron, T., Letessier, E., Galmiche, J. P., Sansonetti, P. J. and Neunlist, M. (2009). Characterisation of early mucosal and neuronal lesions following Shigella flexneri infection in human colon. PLoS One 4(3): e4713.
  14. Sansonetti, P. J. (2009). Framing a concept and an agenda for infectious diseases in EMBO Molecular Medicine. EMBO Mol Med 1(4): 193-194.
  15. Paz, I., Sachse, M., Dupont, N., Mounier, J., Cederfur, C., Enninga, J., Leffler, H., Poirier, F., Prevost, M. C., Lafont, F. and Sansonetti, P. (2010). Galectin-3, a marker for vacuole lysis by invasive pathogens. Cell Microbiol 12(4): 530-544.
  16. Sellge, G., Magalhaes, J. G., Konradt, C., Fritz, J. H., Salgado-Pabon, W., Eberl, G., Bandeira, A., Di Santo, J. P., Sansonetti, P. J. and Phalipon, A. (2010). Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity. J Immunol 184(4): 2076-2085.
  17. Ray, K., Bobard, A., Danckaert, A., Paz-Haftel, I., Clair, C., Ehsani, S., Tang, C., Sansonetti, P., Tran, G. V. and Enninga, J. (2010). Tracking the dynamic interplay between bacterial and host factors during pathogen-induced vacuole rupture in real time. Cell Microbiol 12(4): 545-556.
  18. Dharancy, S., Body–Malapel, M., Louvet, A., Berrebi, D., Gantier, E., Gosset, P., Viala, J., Hollebecque, A., Moreno, C. and Philpott, D. J. (2010). Neutrophil migration during liver injury is under nucleotide-binding oligomerization domain 1 control. Gastroenterology 138(4): 1546-1556. e1545.
  19. Marteyn, B., West, N. P., Browning, D. F., Cole, J. A., Shaw, J. G., Palm, F., Mounier, J., Prevost, M. C., Sansonetti, P. and Tang, C. M. (2010). Modulation of Shigella virulence in response to available oxygen in vivo. Nature 465(7296): 355-358.
  20. Garcia-Sastre, A. and Sansonetti, P. J. (2010). Host-pathogen interactions. Curr Opin Immunol 22(4): 425-427.
  21. Sansonetti, P. J. (2011). To be or not to be a pathogen: that is the mucosally relevant question. Mucosal Immunol 4(1): 8-14.
  22. Flamant, M., Aubert, P., Rolli-Derkinderen, M., Bourreille, A., Neunlist, M. R., Mahe, M. M., Meurette, G., Marteyn, B., Savidge, T., Galmiche, J. P., Sansonetti, P. J. and Neunlist, M. (2011). Enteric glia protect against Shigella flexneri invasion in intestinal epithelial cells: a role for S-nitrosoglutathione. Gut 60(4): 473-484.
  23. Rahman, K. M., Arifeen, S. E., Zaman, K., Rahman, M., Raqib, R., Yunus, M., Begum, N., Islam, M. S., Sohel, B. M., Rahman, M., Venkatesan, M., Hale, T. L., Isenbarger, D. W., Sansonetti, P. J., Black, R. E. and Baqui, A. H. (2011). Safety, dose, immunogenicity, and transmissibility of an oral live attenuated Shigella flexneri 2a vaccine candidate (SC602) among healthy adults and school children in Matlab, Bangladesh. Vaccine 29(6): 1347-1354.
  24. Romero, S., Grompone, G., Carayol, N., Mounier, J., Guadagnini, S., Prevost, M. C., Sansonetti, P. J. and Van Nhieu, G. T. (2011). ATP-mediated Erk1/2 activation stimulates bacterial capture by filopodia, which precedes Shigella invasion of epithelial cells. Cell Host Microbe 9(6): 508-519.
  25. Fevre, C., Passet, V., Deletoile, A., Barbe, V., Frangeul, L., Almeida, A. S., Sansonetti, P., Tournebize, R. and Brisse, S. (2011). PCR-based identification of Klebsiella pneumoniae subsp. rhinoscleromatis, the agent of rhinoscleroma. PLoS Negl Trop Dis 5(5): e1052.
  26. Konradt, C., Frigimelica, E., Nothelfer, K., Puhar, A., Salgado-Pabon, W., di Bartolo, V., Scott-Algara, D., Rodrigues, C. D., Sansonetti, P. J. and Phalipon, A. (2011). The Shigella flexneri type three secretion system effector IpgD inhibits T cell migration by manipulating host phosphoinositide metabolism. Cell Host Microbe 9(4): 263-272.
  27. Jehl, S. P., Doling, A. M., Giddings, K. S., Phalipon, A., Sansonetti, P. J., Goldberg, M. B. and Starnbach, M. N. (2011). Antigen-specific CD8(+) T cells fail to respond to Shigella flexneri. Infect Immun 79(5): 2021-2030.
  28. Kufer, T. A. and Sansonetti, P. J. (2011). NLR functions beyond pathogen recognition. Nat Immunol 12(2): 121-128.
  29. Marteyn, B., Scorza, F. B., Sansonetti, P. J. and Tang, C. (2011). Breathing life into pathogens: the influence of oxygen on bacterial virulence and host responses in the gastrointestinal tract. Cell Microbiol 13(2): 171-176.
  30. Taneja, N., Nato, F., Dartevelle, S., Sire, J. M., Garin, B., Thi Phuong, L. N., Diep, T. T., Shako, J. C., Bimet, F., Filliol, I., Muyembe, J. J., Ungeheuer, M. N., Ottone, C., Sansonetti, P. and Germani, Y. (2011). Dipstick test for rapid diagnosis of Shigella dysenteriae 1 in bacterial cultures and its potential use on stool samples. PLoS One 6(10): e24830.
  31. Ramel, D., Lagarrigue, F., Pons, V., Mounier, J., Dupuis-Coronas, S., Chicanne, G., Sansonetti, P. J., Gaits-Iacovoni, F., Tronchere, H. and Payrastre, B. (2011). Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling. Sci Signal 4(191): ra61.
  32. Amar, J., Chabo, C., Waget, A., Klopp, P., Vachoux, C., Bermudez-Humaran, L. G., Smirnova, N., Berge, M., Sulpice, T., Lahtinen, S., Ouwehand, A., Langella, P., Rautonen, N., Sansonetti, P. J. and Burcelin, R. (2011). Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med 3(9): 559-572.
  33. Pédron, T., Mulet, C., Dauga, C., Frangeul, L., Chervaux, C., Grompone, G. and Sansonetti, P. J. (2012). A crypt-specific core microbiota resides in the mouse colon. MBio 3(3): e00116-00112.
  34. Licandro-Seraut, H., Brinster, S., van de Guchte, M., Scornec, H., Maguin, E., Sansonetti, P., Cavin, J. F. and Serror, P. (2012). Development of an efficient in vivo system (Pjunc-TpaseIS1223) for random transposon mutagenesis of Lactobacillus casei. Appl Environ Microbiol 78(15): 5417-5423.
  35. Ehsani, S., Santos, J. C., Rodrigues, C. D., Henriques, R., Audry, L., Zimmer, C., Sansonetti, P., Tran Van Nhieu, G. and Enninga, J. (2012). Hierarchies of host factor dynamics at the entry site of Shigella flexneri during host cell invasion. Infect Immun 80(7): 2548-2557.
  36. Bongrand, C., Sansonetti, P. J. and Parsot, C. (2012). Characterization of the promoter, MxiE box and 5' UTR of genes controlled by the activity of the type III secretion apparatus in Shigella flexneri. PLoS One 7(3): e32862.
  37. Coic, Y. M., Baleux, F., Poyraz, O., Thibeaux, R., Labruyere, E., Chretien, F., Sobhani, I., Lazure, T., Wyplosz, B., Schneider, G., Mulard, L., Sansonetti, P. J. and Marteyn, B. S. (2012). Design of a specific colonic mucus marker using a human commensal bacterium cell surface domain. J Biol Chem 287(19): 15916-15922.
  38. Bergounioux, J., Elisee, R., Prunier, A. L., Donnadieu, F., Sperandio, B., Sansonetti, P. and Arbibe, L. (2012). Calpain activation by the Shigella flexneri effector VirA regulates key steps in the formation and life of the bacterium's epithelial niche. Cell Host Microbe 11(3): 240-252.
  39. Payrastre, B., Gaits-Iacovoni, F., Sansonetti, P. and Tronchere, H. (2012). Phosphoinositides and cellular pathogens. Subcell Biochem 59: 363-388.
  40. Marteyn, B., Gazi, A. and Sansonetti, P. (2012). Shigella: a model of virulence regulation in vivo. Gut microbes 3(2): 104.
  41. Schnupf, P. and Sansonetti, P. J. (2012). Quantitative RT-PCR profiling of the rabbit immune response: assessment of acute Shigella flexneri infection. PLoS One 7(6): e36446.
  42. Panchalingam, S., Antonio, M., Hossain, A., Mandomando, I., Ochieng, B., Oundo, J., Ramamurthy, T., Tamboura, B., Zaidi, A. K. and Petri, W. (2012). Diagnostic microbiologic methods in the GEMS-1 case/control study. Clinical infectious diseases 55(suppl 4): S294-S302.
  43. Mounier, J., Boncompain, G., Senerovic, L., Lagache, T., Chretien, F., Perez, F., Kolbe, M., Olivo-Marin, J. C., Sansonetti, P. J. and Sauvonnet, N. (2012). Shigella effector IpaB-induced cholesterol relocation disrupts the Golgi complex and recycling network to inhibit host cell secretion. Cell Host Microbe 12(3): 381-389.
  44. Karch, H., Denamur, E., Dobrindt, U., Finlay, B. B., Hengge, R., Johannes, L., Ron, E. Z., Tonjum, T., Sansonetti, P. J. and Vicente, M. (2012). The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak. EMBO Mol Med 4(9): 841-848.
  45. Teo, I., Toms, S. M., Marteyn, B., Barata, T. S., Simpson, P., Johnston, K. A., Schnupf, P., Puhar, A., Bell, T., Tang, C., Zloh, M., Matthews, S., Rendle, P. M., Sansonetti, P. J. and Shaunak, S. (2012). Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers. EMBO Mol Med 4(9): 866-881.
  46. Erlich, P. and Sansonetti, P. J. (2013). [Acute intestinal infections: current and upcoming vaccines]. Presse Med 42(1): 93-101.
  47. Salgado-Pabon, W., Celli, S., Arena, E. T., Nothelfer, K., Roux, P., Sellge, G., Frigimelica, E., Bousso, P., Sansonetti, P. J. and Phalipon, A. (2013). Shigella impairs T lymphocyte dynamics in vivo. Proc Natl Acad Sci U S A 110(12): 4458-4463.
  48. Matsuki, T., Pedron, T., Regnault, B., Mulet, C., Hara, T. and Sansonetti, P. J. (2013). Epithelial cell proliferation arrest induced by lactate and acetate from Lactobacillus casei and Bifidobacterium breve. PLoS One 8(4): e63053.
  49. Fevre, C., Almeida, A. S., Taront, S., Pedron, T., Huerre, M., Prevost, M. C., Kieusseian, A., Cumano, A., Brisse, S., Sansonetti, P. J. and Tournebize, R. (2013). A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL-10 dependent derivatives of inflammatory monocytes. EMBO Mol Med 5(4): 516-530.
  50. Van Nhieu, G. T., Liu, B. K., Zhang, J., Pierre, F., Prigent, S., Sansonetti, P., Erneux, C., Kim, J. K., Suh, P.-G. and Dupont, G. (2013). Actin-based confinement of calcium responses during Shigella invasion. Nature communications 4: 1567.
  51. Puhar, A., Tronchere, H., Payrastre, B., Nhieu, G. T. and Sansonetti, P. J. (2013). A Shigella effector dampens inflammation by regulating epithelial release of danger signal ATP through production of the lipid mediator PtdIns5P. Immunity 39(6): 1121-1131.
Protocols by Philippe J. Sansonetti
  1. Induction of Connexin-hemichannel Opening
  2. Dye-uptake Experiment through Connexin Hemichannels
  3. Design of a Transcription-based Secretion Activity Reporter (TSAR) for the Type III Secretion Apparatus of Shigella flexneri and Uses Thereof
  4. Detection of the Secreted and Cytoplasmic Fractions of IpaB, IpaC and IpaD by Lysozyme Permeabilization