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Warner C. Greene


M.D., Ph.D. in Medicine and Immunology, Washington Univ. School of Medicine, St. Louis, 1977

Current position

Director, Gladstone Institute of Virology and Immunology; Professor of Medicine, Microbiology and Immunology, University of California, San Francisco; Co-Director, UCSF– GIVI Center for AIDS Research (1992-present)
Nick and Sue Hellmann Distinguished Professor of Translational Research (2006-present)
Executive Chairman, Accordia Global Health Foundation (2013-present)


Peer-Reviewed Publications Selected from a total of 368

  1. Doitsh, G., Galloway, N. L., Geng, X., Yang, Z., Monroe, K. M., Zepeda, O., Hunt, P. W., Hatano, H., Sowinski, S., Munoz-Arias, I. and Greene, W. C. (2014). Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature 505(7484): 509-514.
  2. Monroe, K. M., Yang, Z., Johnson, J. R., Geng, X., Doitsh, G., Krogan, N. J. and Greene, W. C. (2014). IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science 343(6169): 428-432.
  3. Wissing, S., Munoz-Lopez, M., Macia, A., Yang, Z., Montano, M., Collins, W., Garcia-Perez, J. L., Moran, J. V. and Greene, W. C. (2012). Reprogramming somatic cells into iPS cells activates LINE-1 retroelement mobility. Hum Mol Genet 21(1): 208-218.
  4. Roan, N. R., Muller, J. A., Liu, H., Chu, S., Arnold, F., Sturzel, C. M., Walther, P., Dong, M., Witkowska, H. E., Kirchhoff, F., Munch, J. and Greene, W. C. (2011). Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection. Cell Host Microbe 10(6): 541-550.
  5. Doitsh, G., Cavrois, M., Lassen, K. G., Zepeda, O., Yang, Z., Santiago, M. L., Hebbeler, A. M. and Greene, W. C. (2010). Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell 143(5): 789-801.
  6. Santiago, M. L., Montano, M., Benitez, R., Messer, R. J., Yonemoto, W., Chesebro, B., Hasenkrug, K. J. and Greene, W. C. (2008). Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science 321(5894): 1343-1346.
  7. Chiu, Y. L., Witkowska, H. E., Hall, S. C., Santiago, M., Soros, V. B., Esnault, C., Heidmann, T. and Greene, W. C. (2006). High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition. Proc Natl Acad Sci U S A 103(42): 15588-15593.
  8. Stopak, K., de Noronha, C., Yonemoto, W. and Greene, W. C. (2003). HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. Mol Cell 12(3): 591-601.
  9. Geleziunas, R., Xu, W., Takeda, K., Ichijo, H. and Greene, W. C. (2001). HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell. Nature 410(6830): 834-838.
  10. Chen, L., Fischle, W., Verdin, E. and Greene, W. C. (2001). Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science 293(5535): 1653-1657.
  11. de Noronha, C. M., Sherman, M. P., Lin, H. W., Cavrois, M. V., Moir, R. D., Goldman, R. D. and Greene, W. C. (2001). Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science 294(5544): 1105-1108.
  12. Sun, S. C., Ganchi, P. A., Ballard, D. W. and Greene, W. C. (1993). NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science 259(5103): 1912-1915.
  13. Bohnlein, E., Lowenthal, J. W., Siekevitz, M., Ballard, D. W., Franza, B. R. and Greene, W. C. (1988). The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV. Cell 53(5): 827-836.
  14. Kronke, M., Leonard, W. J., Depper, J. M. and Greene, W. C. (1985). Deregulation of interleukin-2 receptor gene expression in HTLV-I-induced adult T-cell leukemia. Science 228(4704): 1215-1217.
  15. Leonard, W. J., Depper, J. M., Crabtree, G. R., Rudikoff, S., Pumphrey, J., Robb, R. J., Kronke, M., Svetlik, P. B., Peffer, N. J., Waldmann, T. A. and et al. (1984). Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature 311(5987): 626-631.
Protocols by Warner C. Greene
  1. HIV-1 Fusion Assay