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Jason Neidleman


B.A. in Biochemistry and Molecular Biology, University of California at Santa Barbara, 1994

Current position

Senior Research Associate in the Greene Lab, GIVI, J. David Gladstone Institutes


  1. Roan, N. R., Liu, H., Usmani, S. M., Neidleman, J., Muller, J. A., Avila-Herrera, A., Gawanbacht, A., Zirafi, O., Chu, S., Dong, M., Kumar, S. T., Smith, J. F., Pollard, K. S., Fandrich, M., Kirchhoff, F., Munch, J., Witkowska, H. E. and Greene, W. C. (2014). Liquefaction of Semen Generates and Later Degrades a Conserved Semenogelin Peptide That Enhances HIV Infection. J Virol 88(13): 7221-7234.
  2. Roan, N. R., Chu, S., Liu, H., Neidleman, J., Witkowska, H. E. and Greene, W. C. (2014). Interaction of Fibronectin With Semen Amyloids Synergistically Enhances HIV Infection. J Infect Dis.
  3. Cavrois, M., Neidleman, J., Santiago, M. L., Derdeyn, C. A., Hunter, E. and Greene, W. C. (2014). Enhanced fusion and virion incorporation for HIV-1 subtype C envelope glycoproteins with compact V1/V2 domains. J Virol 88(4): 2083-2094.
  4. Cavrois, M., Neidleman, J., Galloway, N., Derdeyn, C. A., Hunter, E. and Greene, W. C. (2011). Measuring HIV fusion mediated by envelopes from primary viral isolates. Methods 53(1): 34-38.
  5. Roan, N. R., Munch, J., Arhel, N., Mothes, W., Neidleman, J., Kobayashi, A., Smith-McCune, K., Kirchhoff, F. and Greene, W. C. (2009). The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection. J Virol 83(1): 73-80.
  6. Cavrois, M., Neidleman, J. and Greene, W. C. (2008). The achilles heel of the trojan horse model of HIV-1 trans-infection. PLoS Pathog 4(6): e1000051.
  7. Cavrois, M., Neidleman, J., Kreisberg, J. F. and Greene, W. C. (2007). In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions. PLoS Pathog 3(1): e4.
  8. Zimmerman, E. S., Sherman, M. P., Blackett, J. L., Neidleman, J. A., Kreis, C., Mundt, P., Williams, S. A., Warmerdam, M., Kahn, J., Hecht, F. M., Grant, R. M., de Noronha, C. M., Weyrich, A. S., Greene, W. C. and Planelles, V. (2006). Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo. J Virol 80(21): 10407-10418.
  9. Cavrois, M., Neidleman, J., Kreisberg, J. F., Fenard, D., Callebaut, C. and Greene, W. C. (2006). Human immunodeficiency virus fusion to dendritic cells declines as cells mature. J Virol 80(4): 1992-1999.
  10. Cavrois, M., Neidleman, J., Yonemoto, W., Fenard, D. and Greene, W. C. (2004). HIV-1 virion fusion assay: uncoating not required and no effect of Nef on fusion. Virology 328(1): 36-44.
  11. Cavrois, M., Neidleman, J., Bigos, M. and Greene, W. C. (2004). Fluorescence resonance energy transfer-based HIV-1 virion fusion assay. Methods Mol Biol 263: 333-344.
  12. Bruns, K., Fossen, T., Wray, V., Henklein, P., Tessmer, U. and Schubert, U. (2003). Structural characterization of the HIV-1 Vpr N Terminus evidence of cis/trans-proline isomerism. Journal of Biological Chemistry 278(44): 43188-43201.
  13. Zander, K., Sherman, M. P., Tessmer, U., Bruns, K., Wray, V., Prechtel, A. T., Schubert, E., Henklein, P., Luban, J., Neidleman, J., Greene, W. C. and Schubert, U. (2003). Cyclophilin A interacts with HIV-1 Vpr and is required for its functional expression. J Biol Chem 278(44): 43202-43213.
  14. Sherman, M. P., de Noronha, C. M., Eckstein, L. A., Hataye, J., Mundt, P., Williams, S. A., Neidleman, J. A., Goldsmith, M. A. and Greene, W. C. (2003). Nuclear export of Vpr is required for efficient replication of human immunodeficiency virus type 1 in tissue macrophages. J Virol 77(13): 7582-7589.
  15. Vajdy, M., Gardner, J., Neidleman, J., Cuadra, L., Greer, C., Perri, S., O'Hagan, D. and Polo, J. M. (2001). Human immunodeficiency virus type 1 Gag-specific vaginal immunity and protection after local immunizations with sindbis virus-based replicon particles. J Infect Dis 184(12): 1613-1616.
  16. Neidleman, J. A., Vajdy, M., Ugozzoli, M., Ott, G. and O'Hagan, D. (2000). Genetically detoxified mutants of heat-labile enterotoxin from Escherichia coli are effective adjuvants for induction of cytotoxic T-cell responses against HIV-1 gag-p55. Immunology 101(1): 154-160.
  17. Kazzaz, J., Neidleman, J., Singh, M., Ott, G. and O'Hagan, D. T. (2000). Novel anionic microparticles are a potent adjuvant for the induction of cytotoxic T lymphocytes against recombinant p55 gag from HIV-1. J Control Release 67(2-3): 347-356.

Protocols by Jason Neidleman
  1. HIV-1 Fusion Assay