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Marielle Cavrois


Ph.D. summa cum laude in Molecular and Cellular Biology, University of Lille, France, 1997

Current position

Director of the Gladstone Flow Cytometry Laboratory, Gladstone Institutes, San Francisco (2009-present)
Assistant Professor, Department of Medicine, UCSF, San Francisco (2012-present)


  1. Cavrois, M., Neidleman, J., Santiago, M. L., Derdeyn, C. A., Hunter, E. and Greene, W. C. (2014). Enhanced fusion and virion incorporation for HIV-1 subtype C envelope glycoproteins with compact V1/V2 domains. J Virol 88(4): 2083-2094.
  2. Roan, N. R., Cavrois, M. and Greene, W. C. (2012). Role of semen-derived amyloid fibrils as facilitators of HIV infection. Med Sci (Paris) 28(4): 358-360.
  3. Cavrois, M., Neidleman, J., Galloway, N., Derdeyn, C. A., Hunter, E. and Greene, W. C. (2011). Measuring HIV fusion mediated by envelopes from primary viral isolates. Methods 53(1): 34-38.
  4. Doitsh, G., Cavrois, M., Lassen, K. G., Zepeda, O., Yang, Z., Santiago, M. L., Hebbeler, A. M. and Greene, W. C. (2010). Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell 143(5): 789-801.
  5. Burt, T. D., Agan, B. K., Marconi, V. C., He, W., Kulkarni, H., Mold, J. E., Cavrois, M., Huang, Y., Mahley, R. W., Dolan, M. J., McCune, J. M. and Ahuja, S. K. (2008). Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A 105(25): 8718-8723.
  6. Cavrois, M., Neidleman, J. and Greene, W. C. (2008). The achilles heel of the trojan horse model of HIV-1 trans-infection. PLoS Pathog 4(6): e1000051.
  7. Cavrois, M., Neidleman, J., Kreisberg, J. F. and Greene, W. C. (2007). In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions. PLoS Pathog 3(1): e4.
  8. Cavrois, M., Neidleman, J., Kreisberg, J. F., Fenard, D., Callebaut, C. and Greene, W. C. (2006). Human immunodeficiency virus fusion to dendritic cells declines as cells mature. J Virol 80(4): 1992-1999.
  9. Fenard, D., Yonemoto, W., de Noronha, C., Cavrois, M., Williams, S. A. and Greene, W. C. (2005). Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement. J Immunol 175(9): 6050-6057.
  10. Yonezawa, A., Cavrois, M. and Greene, W. C. (2005). Studies of ebola virus glycoprotein-mediated entry and fusion by using pseudotyped human immunodeficiency virus type 1 virions: involvement of cytoskeletal proteins and enhancement by tumor necrosis factor alpha. J Virol 79(2): 918-926.
  11. Cavrois, M., Neidleman, J., Yonemoto, W., Fenard, D. and Greene, W. C. (2004). HIV-1 virion fusion assay: uncoating not required and no effect of Nef on fusion. Virology 328(1): 36-44.
  12. Cavrois, M., Neidleman, J., Bigos, M. and Greene, W. C. (2004). Fluorescence resonance energy transfer-based HIV-1 virion fusion assay. Methods Mol Biol 263: 333-344.
  13. Cavrois, M., de Noronha, C. and Greene, W. C. (2002). A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes. Nature biotechnology 20(11): 1151-1154.
  14. de Noronha, C. M., Sherman, M. P., Lin, H. W., Cavrois, M. V., Moir, R. D., Goldman, R. D. and Greene, W. C. (2001). Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science 294(5544): 1105-1108.
  15. Pati, S., Cavrois, M., Guo, H. G., Foulke, J. S., Jr., Kim, J., Feldman, R. A. and Reitz, M. (2001). Activation of NF-kappaB by the human herpesvirus 8 chemokine receptor ORF74: evidence for a paracrine model of Kaposi's sarcoma pathogenesis. J Virol 75(18): 8660-8673.
  16. Cavrois, M., Gessain, A., Gout, O., Wain-Hobson, S. and Wattel, E. (2000). Common human T cell leukemia virus type 1 (HTLV-1) integration sites in cerebrospinal fluid and blood lymphocytes of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis indicate that HTLV-1 crosses the blood-brain barrier via clonal HTLV-1-infected cells. J Infect Dis 182(4): 1044-1050.
  17. Leclercq, I., Mortreux, F., Cavrois, M., Leroy, A., Gessain, A., Wain-Hobson, S. and Wattel, E. (2000). Host sequences flanking the human T-cell leukemia virus type 1 provirus in vivo. J Virol 74(5): 2305-2312.
  18. Leclercq, I., Mortreux, F., Morschhauser, F., Duthilleul, P., Desgranges, C., Gessain, A., Cavrois, M., Vernant, J. P., Hermine, O. and Wattel, E. (1999). Semiquantitative analysis of residual disease in patients treated for adult T-cell leukaemia/lymphoma (ATLL). Br J Haematol 105(3): 743-751.
  19. Agape, P., Copin, M. C., Cavrois, M., Panelatti, G., Plumelle, Y., Ossondo-Landeau, M., Quist, D., Grossat, N., Gosselin, B., Fenaux, P. and Wattel, E. (1999). Implication of HTLV-I infection, strongyloidiasis, and P53 overexpression in the development, response to treatment, and evolution of non-Hodgkin's lymphomas in an endemic area (Martinique, French West Indies). J Acquir Immune Defic Syndr Hum Retrovirol 20(4): 394-402.
  20. Cavrois, M., Leclercq, I., Gout, O., Gessain, A., Wain-Hobson, S. and Wattel, E. (1998). Persistent oligoclonal expansion of human T-cell leukemia virus type 1-infected circulating cells in patients with Tropical spastic paraparesis/HTLV-1 associated myelopathy. Oncogene 17(1): 77-82.
  21. Leclercq, I., Cavrois, M., Mortreux, F., Hermine, O., Gessain, A., Morschhauser, F. and Wattel, E. (1998). Oligoclonal proliferation of human T-cell leukaemia virus type 1 bearing T cells in adult T-cell leukaemia/lymphoma without deletion of the 3' provirus integration sites. Br J Haematol 101(3): 500-506.
  22. Cavrois, M., Leclercq, I., Mortreux, F. and Wattel, E. (1997). Oncogenèse liée à l'infection par HTLV-1: Données récentes. Hématoscopie, 10:12–18.
  23. Cavrois, M., Wain-Hobson, S., Gessain, A., Plumelle, Y. and Wattel, E. (1996). Adult T-cell leukemia/lymphoma on a background of clonally expanding human T-cell leukemia virus type-1-positive cells. Blood 88(12): 4646-4650.
  24. Wattel, E., Cavrois, M., Gessain, A. and Wain-Hobson, S. (1996). Clonal expansion of infected cells: a way of life for HTLV-I. J Acquir Immune Defic Syndr Hum Retrovirol 13 Suppl 1: S92-99.
  25. Cavrois, M., Gessain, A., Wain-Hobson, S. and Wattel, E. (1996). Proliferation of HTLV-1 infected circulating cells in vivo in all asymptomatic carriers and patients with TSP/HAM. Oncogene 12(11): 2419-2423.
  26. Cavrois, M., Wain-Hobson, S. and Wattel, E. (1995). Stochastic events in the amplification of HTLV-I integration sites by linker-mediated PCR. Res Virol 146(3): 179-184.
  27. Cavrois, M. and Wattel, E. (1995). HTLV-1 et pathologie hématologique. Hématologie 1(1): 45-51.
Protocols by Marielle Cavrois
  1. HIV-1 Fusion Assay
  2. Fluorescence-linked Antigen Quantification (FLAQ) Assay for Fast Quantification of HIV-1 p24Gag