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Marielle   Cavrois

Marielle Cavrois


Ph.D. summa cum laude in Molecular and Cellular Biology, University of Lille, France, 1997

Current position

Director of the Gladstone Flow Cytometry Laboratory, Gladstone Institutes, San Francisco (2009-present)
Assistant Professor, Department of Medicine, UCSF, San Francisco (2012-present)


  1. Cavrois, M., Neidleman, J., Santiago, M. L., Derdeyn, C. A., Hunter, E. and Greene, W. C. (2014). Enhanced fusion and virion incorporation for HIV-1 subtype C envelope glycoproteins with compact V1/V2 domains. J Virol 88(4): 2083-2094.
  2. Roan, N. R., Cavrois, M. and Greene, W. C. (2012). Role of semen-derived amyloid fibrils as facilitators of HIV infection. Med Sci (Paris) 28(4): 358-360.
  3. Cavrois, M., Neidleman, J., Galloway, N., Derdeyn, C. A., Hunter, E. and Greene, W. C. (2011). Measuring HIV fusion mediated by envelopes from primary viral isolates. Methods 53(1): 34-38.
  4. Doitsh, G., Cavrois, M., Lassen, K. G., Zepeda, O., Yang, Z., Santiago, M. L., Hebbeler, A. M. and Greene, W. C. (2010). Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell 143(5): 789-801.
  5. Burt, T. D., Agan, B. K., Marconi, V. C., He, W., Kulkarni, H., Mold, J. E., Cavrois, M., Huang, Y., Mahley, R. W., Dolan, M. J., McCune, J. M. and Ahuja, S. K. (2008). Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A 105(25): 8718-8723.
  6. Cavrois, M., Neidleman, J. and Greene, W. C. (2008). The achilles heel of the trojan horse model of HIV-1 trans-infection. PLoS Pathog 4(6): e1000051.
  7. Cavrois, M., Neidleman, J., Kreisberg, J. F. and Greene, W. C. (2007). In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions. PLoS Pathog 3(1): e4.
  8. Cavrois, M., Neidleman, J., Kreisberg, J. F., Fenard, D., Callebaut, C. and Greene, W. C. (2006). Human immunodeficiency virus fusion to dendritic cells declines as cells mature. J Virol 80(4): 1992-1999.
  9. Fenard, D., Yonemoto, W., de Noronha, C., Cavrois, M., Williams, S. A. and Greene, W. C. (2005). Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement. J Immunol 175(9): 6050-6057.
  10. Yonezawa, A., Cavrois, M. and Greene, W. C. (2005). Studies of ebola virus glycoprotein-mediated entry and fusion by using pseudotyped human immunodeficiency virus type 1 virions: involvement of cytoskeletal proteins and enhancement by tumor necrosis factor alpha. J Virol 79(2): 918-926.
  11. Cavrois, M., Neidleman, J., Yonemoto, W., Fenard, D. and Greene, W. C. (2004). HIV-1 virion fusion assay: uncoating not required and no effect of Nef on fusion. Virology 328(1): 36-44.
  12. Cavrois, M., Neidleman, J., Bigos, M. and Greene, W. C. (2004). Fluorescence resonance energy transfer-based HIV-1 virion fusion assay. Methods Mol Biol 263: 333-344.
  13. Cavrois, M., de Noronha, C. and Greene, W. C. (2002). A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes. Nature biotechnology 20(11): 1151-1154.
  14. de Noronha, C. M., Sherman, M. P., Lin, H. W., Cavrois, M. V., Moir, R. D., Goldman, R. D. and Greene, W. C. (2001). Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science 294(5544): 1105-1108.
  15. Pati, S., Cavrois, M., Guo, H. G., Foulke, J. S., Jr., Kim, J., Feldman, R. A. and Reitz, M. (2001). Activation of NF-kappaB by the human herpesvirus 8 chemokine receptor ORF74: evidence for a paracrine model of Kaposi's sarcoma pathogenesis. J Virol 75(18): 8660-8673.
  16. Cavrois, M., Gessain, A., Gout, O., Wain-Hobson, S. and Wattel, E. (2000). Common human T cell leukemia virus type 1 (HTLV-1) integration sites in cerebrospinal fluid and blood lymphocytes of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis indicate that HTLV-1 crosses the blood-brain barrier via clonal HTLV-1-infected cells. J Infect Dis 182(4): 1044-1050.
  17. Leclercq, I., Mortreux, F., Cavrois, M., Leroy, A., Gessain, A., Wain-Hobson, S. and Wattel, E. (2000). Host sequences flanking the human T-cell leukemia virus type 1 provirus in vivo. J Virol 74(5): 2305-2312.
  18. Leclercq, I., Mortreux, F., Morschhauser, F., Duthilleul, P., Desgranges, C., Gessain, A., Cavrois, M., Vernant, J. P., Hermine, O. and Wattel, E. (1999). Semiquantitative analysis of residual disease in patients treated for adult T-cell leukaemia/lymphoma (ATLL). Br J Haematol 105(3): 743-751.
  19. Agape, P., Copin, M. C., Cavrois, M., Panelatti, G., Plumelle, Y., Ossondo-Landeau, M., Quist, D., Grossat, N., Gosselin, B., Fenaux, P. and Wattel, E. (1999). Implication of HTLV-I infection, strongyloidiasis, and P53 overexpression in the development, response to treatment, and evolution of non-Hodgkin's lymphomas in an endemic area (Martinique, French West Indies). J Acquir Immune Defic Syndr Hum Retrovirol 20(4): 394-402.
  20. Cavrois, M., Leclercq, I., Gout, O., Gessain, A., Wain-Hobson, S. and Wattel, E. (1998). Persistent oligoclonal expansion of human T-cell leukemia virus type 1-infected circulating cells in patients with Tropical spastic paraparesis/HTLV-1 associated myelopathy. Oncogene 17(1): 77-82.
  21. Leclercq, I., Cavrois, M., Mortreux, F., Hermine, O., Gessain, A., Morschhauser, F. and Wattel, E. (1998). Oligoclonal proliferation of human T-cell leukaemia virus type 1 bearing T cells in adult T-cell leukaemia/lymphoma without deletion of the 3' provirus integration sites. Br J Haematol 101(3): 500-506.
  22. Cavrois, M., Leclercq, I., Mortreux, F. and Wattel, E. (1997). Oncogenèse liée à l'infection par HTLV-1: Données récentes. Hématoscopie, 10:12–18.
  23. Cavrois, M., Wain-Hobson, S., Gessain, A., Plumelle, Y. and Wattel, E. (1996). Adult T-cell leukemia/lymphoma on a background of clonally expanding human T-cell leukemia virus type-1-positive cells. Blood 88(12): 4646-4650.
  24. Wattel, E., Cavrois, M., Gessain, A. and Wain-Hobson, S. (1996). Clonal expansion of infected cells: a way of life for HTLV-I. J Acquir Immune Defic Syndr Hum Retrovirol 13 Suppl 1: S92-99.
  25. Cavrois, M., Gessain, A., Wain-Hobson, S. and Wattel, E. (1996). Proliferation of HTLV-1 infected circulating cells in vivo in all asymptomatic carriers and patients with TSP/HAM. Oncogene 12(11): 2419-2423.
  26. Cavrois, M., Wain-Hobson, S. and Wattel, E. (1995). Stochastic events in the amplification of HTLV-I integration sites by linker-mediated PCR. Res Virol 146(3): 179-184.
  27. Cavrois, M. and Wattel, E. (1995). HTLV-1 et pathologie hématologique. Hématologie 1(1): 45-51.
Protocols by Marielle Cavrois
  1. HIV-1 Fusion Assay
  2. Fluorescence-linked Antigen Quantification (FLAQ) Assay for Fast Quantification of HIV-1 p24Gag