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Martin   Kolev

Martin Kolev


Ph.D. in Immunology, Cardiff University, UK

Current position

Research associate, King’s College London, DTIMB, London, UK (2012-to date)


Original publications

  1. Liszewski, M. K.*, Kolev, M.*, Le Friec, G., Leung, M., Bertram, P. G., Fara, A. F., Subias, M., Pickering, M. C., Drouet, C., Meri, S., Arstila, T. P., Pekkarinen, P. T., Ma, M., Cope, A., Reinheckel, T., Rodriguez de Cordoba, S., Afzali, B., Atkinson, J. P. and Kemper, C. (2013). Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation. Immunity 39(6): 1143-1157
  2. Tediose, T.*, Kolev, M.*, Sivasankar, B., Brennan, P., Morgan, B. P. and Donev, R. (2010). Interplay between REST and nucleolin transcription factors: a key mechanism in the overexpression of genes upon increased phosphorylation. Nucleic Acids Res 38(9): 2799-2812
  3. Kolev, M. V., Tediose, T., Sivasankar, B., Harris, C. L., Thome, J., Morgan, B. P. and Donev, R. M. (2010). Upregulating CD59: a new strategy for protection of neurons from complement-mediated degeneration. Pharmacogenomics J 10(1): 12-19.
  4. Thiel, S., Kolev, M., Degn, S., Steffensen, R., Hansen, A. G., Ruseva, M. and Jensenius, J. C. (2009). Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. J Immunol 182(5): 2939-2947.
  5. Ruseva, M., Kolev, M., Dagnaes-Hansen, F., Hansen, S. B., Takahashi, K., Ezekowitz, A., Thiel, S., Jensenius, J. C. and Gadjeva, M. (2009). Mannan-binding lectin deficiency modulates the humoral immune response dependent on the genetic environment. Immunology 127(2): 279-288.
  6. Roumenina, L. T., Ruseva, M. M., Zlatarova, A., Ghai, R., Kolev, M., Olova, N., Gadjeva, M., Agrawal, A., Bottazzi, B., Mantovani, A., Reid, K. B., Kishore, U. and Kojouharova, M. S. (2006). Interaction of C1q with IgG1, C-reactive protein and pentraxin 3: mutational studies using recombinant globular head modules of human C1q A, B, and C chains. Biochemistry 45(13): 4093-4104.
  7. Zlatarova, A. S., Rouseva, M., Roumenina, L. T., Gadjeva, M., Kolev, M., Dobrev, I., Olova, N., Ghai, R., Jensenius, J. C., Reid, K. B., Kishore, U. and Kojouharova, M. S. (2006). Existence of different but overlapping IgG- and IgM-binding sites on the globular domain of human C1q. Biochemistry 45(33): 9979-9988.
    *Shared first position

Invited peer-reviewed publications

  1. Kolev, M., Le Friec, G. and Kemper, C. (2013). The role of complement in CD4(+) T cell homeostasis and effector functions. Semin Immunol 25(1): 12-19.
  2. Kolev, M., Towner, L. and Donev, R. (2011). Complement in cancer and cancer immunotherapy. Arch Immunol Ther Exp (Warsz) 59(6): 407-419.
  3. Donev, R., Kolev, M., Millet, B. and Thome, J. (2009). Neuronal death in Alzheimer's disease and therapeutic opportunities. J Cell Mol Med 13(11-12): 4329-4348.
  4. Kolev, M. V., Ruseva, M. M., Harris, C. L., Morgan, B. P. and Donev, R. M. (2009). Implication of complement system and its regulators in Alzheimer's disease. Curr Neuropharmacol 7(1): 1-8.

Book chapters

  1. Kolev, M. (2014). Functional analysis of CD59 using complement-dependent cytotoxicity assay. Methods Mol Biol 1100: 347-353.
  2. Kolev, M. (2014). Detection of CD59 using flow cytometry. Methods Mol Biol 1100: 341-346.
  3. Kolev, M. and Kemper, C. (2014). Detection of cell membrane-bound CD46 using flow cytometry. Methods Mol Biol 1100: 329-339.
Protocols by Martin Kolev
  1. Enzymatic Reactions and Detection of C3 Cleavage Fragments