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Claudia Kemper

Education

Ph.D. in Immunology, Bernhardt-Nocht-Institute for Tropical Med., Hamburg, Germany, 1998

Current position

Reader in Transplant Immunology (permanent/tenured position), MRC Centre for Transplantation, King’s College London (HEFCE), UK (2012-date)

Publications

Original publications

  1. Ghannam, A., Fauquert, J. L., Thomas, C., Kemper, C. and Drouet, C. (2014). Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation. Mol Immunol 58(1): 98-107.
  2. Liszewski, M. K., Kolev, M., Le Friec, G., Leung, M., Bertram, P. G., Fara, A. F., Subias, M., Pickering, M. C., Drouet, C., Meri, S., Arstila, T. P., Pekkarinen, P. T., Ma, M., Cope, A., Reinheckel, T., Rodriguez de Cordoba, S., Afzali, B., Atkinson, J. P. and Kemper, C. (2013). Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation. Immunity 39(6): 1143-1157.
  3. Asgari, E., Le Friec, G., Yamamoto, H., Perucha, E., Sacks, S. S., Köhl, J., Cook, H. T. and Kemper, C. (2013). C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. Blood 122(20): 3473-3481.
  4. Le Friec, G., Kohl, J. and Kemper, C. (2013). A complement a day keeps the Fox(p3) away. Nat Immunol 14(2): 110-112.
  5. Le Friec, G., Sheppard, D., Whiteman, P., Karsten, C. M., Shamoun, S. A., Laing, A., Bugeon, L., Dallman, M. J., Melchionna, T., Chillakuri, C., Smith, R. A., Drouet, C., Couzi, L., Fremeaux-Bacchi, V., Kohl, J., Waddington, S. N., McDonnell, J. M., Baker, A., Handford, P. A., Lea, S. M. and Kemper, C. (2012). The CD46-Jagged1 interaction is critical for human TH1 immunity. Nat Immunol 13(12): 1213-1221.
  6. Cardone, J., Al-Shouli, S. and Kemper, C. (2011). A novel role for CD46 in wound repair. Front Immunol 2: 28.
  7. Truscott, S. M., Abate, G., Price, J. D., Kemper, C., Atkinson, J. P. and Hoft, D. F. (2010). CD46 engagement on human CD4+ T cells produces T regulatory type 1-like regulation of antimycobacterial T cell responses. Infect Immun 78(12): 5295-5306.
  8. Cardone, J., Le Friec, G., Vantourout, P., Roberts, A., Fuchs, A., Jackson, I., Suddason, T., Lord, G., Atkinson, J. P., Cope, A., Hayday, A. and Kemper, C. (2010). Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells. Nat Immunol 11(9): 862-871.
  9. Fuchs, A., Atkinson, J. P., Fremeaux-Bacchi, V. and Kemper, C. (2009). CD46-induced human Treg enhance B-cell responses. Eur J Immunol 39(11): 3097-3109.
  10. Lan, R. Y., Salunga, T. L., Tsuneyama, K., Lian, Z. X., Yang, G. X., Hsu, W., Moritoki, Y., Ansari, A. A., Kemper, C., Price, J., Atkinson, J. P., Coppel, R. L. and Gershwin, M. E. (2009). Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J Autoimmun 32(1): 43-51.
  11. Alford, S. K., Longmore, G. D., Stenson, W. F. and Kemper, C. (2008). CD46-induced immunomodulatory CD4+ T cells express the adhesion molecule and chemokine receptor pattern of intestinal T cells. J Immunol 181(4): 2544-2555.
  12. Kemper, C., Mitchell, L. M., Zhang, L. and Hourcade, D. E. (2008). The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis. Proc Natl Acad Sci U S A 105(26): 9023-9028.
  13. Barchet, W., Price, J. D., Cella, M., Colonna, M., MacMillan, S. K., Cobb, J. P., Thompson, P. A., Murphy, K. M., Atkinson, J. P. and Kemper, C. (2006). Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation. Blood 107(4): 1497-1504.
  14. Price, J. D., Schaumburg, J., Sandin, C., Atkinson, J. P., Lindahl, G. and Kemper, C. (2005). Induction of a regulatory phenotype in human CD4+ T cells by streptococcal M protein. J Immunol 175(2): 677-684.
  15. Zanjani, H., Finch, C. E., Kemper, C., Atkinson, J., McKeel, D., Morris, J. C. and Price, J. L. (2005). Complement activation in very early Alzheimer disease. Alzheimer Dis Assoc Disord 19(2): 55-66.
  16. Grossman, W. J., Verbsky, J. W., Tollefsen, B. L., Kemper, C., Atkinson, J. P. and Ley, T. J. (2004). Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 104(9): 2840-2848.
  17. Kemper, C., Chan, A. C., Green, J. M., Brett, K. A., Murphy, K. M. and Atkinson, J. P. (2003). Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 421(6921): 388-392.
  18. Riley, R. C., Kemper, C., Leung, M. and Atkinson, J. P. (2002). Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa. Mol Reprod Dev 62(4): 534-546.
  19. Kemper, C., Leung, M., Stephensen, C. B., Pinkert, C. A., Liszewski, M. K., Cattaneo, R. and Atkinson, J. P. (2001). Membrane cofactor protein (MCP; CD46) expression in transgenic mice. Clin Exp Immunol 124(2): 180-189.
  20. Kemper, C., Zipfel, P. F. and Gigli, I. (1998). The complement cofactor protein (SBP1) from the barred sand bass (Paralabrax nebulifer) mediates overlapping regulatory activities of both human C4b binding protein and factor H. J Biol Chem 273(31): 19398-19404.
  21. Krushkal, J., Kemper, C. and Gigli, I. (1998). Ancient origin of human complement factor H. J Mol Evol 47(5): 625-630.
  22. Zipfel, P. F., Kemper, C., Dahmen, A. and Gigli, I. (1996). Cloning and recombinant expression of a barred sand bass (Paralabrax nebulifer) cDNA. The encoded protein displays structural homology and immunological crossreactivity to human complement/cofactor related plasma proteins. Dev Comp Immunol 20(6): 407-416.

Invited peer-reviewed publications

  1. Yamamoto, H., Fara, A. F., Dasgupta, P. and Kemper, C. (2013). CD46: the 'multitasker' of complement proteins. Int J Biochem Cell Biol 45(12): 2808-2820.
  2. Kemper, C. and Kohl, J. (2013). Novel roles for complement receptors in T cell regulation and beyond. Mol Immunol 56(3): 181-190.
  3. Kolev, M., Le Friec, G. and Kemper, C. (2013). The role of complement in CD4(+) T cell homeostasis and effector functions. Semin Immunol 25(1): 12-19.
  4. Heeger, P. S. and Kemper, C. (2012). Novel roles of complement in T effector cell regulation. Immunobiology 217(2): 216-224.
  5. Cardone, J., Le Friec, G. and Kemper, C. (2011). CD46 in innate and adaptive immunity: an update. Clin Exp Immunol 164(3): 301-311.
  6. Cope, A., Le Friec, G., Cardone, J. and Kemper, C. (2011). The Th1 life cycle: molecular control of IFN-gamma to IL-10 switching. Trends Immunol 32(6): 278-286.
  7. Kemper, C., Atkinson, J. P. and Hourcade, D. E. (2010). Properdin: emerging roles of a pattern-recognition molecule. Annu Rev Immunol 28: 131-155.
  8. Le Friec, G. and Kemper, C. (2009). Complement: coming full circle. Arch Immunol Ther Exp (Warsz) 57(6): 393-407.
  9. Kemper, C. and Hourcade, D. E. (2008). Properdin: New roles in pattern recognition and target clearance. Mol Immunol 45(16): 4048-4056.
  10. Kemper, C. and Atkinson, J. P. (2007). T-cell regulation: with complements from innate immunity. Nat Rev Immunol 7(1): 9-18.
  11. Liszewski, M. K., Kemper, C., Price, J. D. and Atkinson, J. P. (2005). Emerging roles and new functions of CD46. Springer Semin Immunopathol 27(3): 345-358.
  12. Kemper, C., Verbsky, J. W., Price, J. D. and Atkinson, J. P. (2005). T-cell stimulation and regulation: with complements from CD46. Immunol Res 32(1-3): 31-43.
  13. Riley-Vargas, R. C., Gill, D. B., Kemper, C., Liszewski, M. K. and Atkinson, J. P. (2004). CD46: expanding beyond complement regulation. Trends Immunol 25(9): 496-503.
  14. Kemper, C., Gigli, I. and Zipfel, P. F. (2000). Conservation of plasma regulatory proteins of the complement system in evolution: humans and fish. Exp Clin Immunogenet 17(2): 55-62.

Book chapters

  1. Kolev, M. and Kemper, C. (2014). Detection of cell membrane-bound CD46 using flow cytometry. Methods Mol Biol 1100: 329-339.
  2. Afzali, B. and Kemper, C. Chapter E 43, Immunity in Chronic Kidney Disease In: Oxford Textbook of Clinical Nephrology. In press for the 2014 new edition.
  3. Atkinson, J. P. and Kemper, C. (2009). CD46. In: Griffin, D. and Oldstone, M. B. A. (eds). Chapter in “Measles virus” in “Current Topics in Microbiology and Immunology”. Springer-Verlag GmbH Berlin Heidelberg, New York LLC and Tokyo Inc.
Protocols by Claudia Kemper
  1. Enzymatic Reactions and Detection of C3 Cleavage Fragments