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Yannick Debing


Ph.D. in Virology, Rega Institute, University of Leuven, Belgium, 2015

Current position

Postdoctoral fellow, Cardiovascular Research Institute Maastricht, Maastricht University, the Netherlands
Research interests: Hepatitis E virus, antiviral therapy, viral myocarditis


  1. Dao Thi, V. L., Debing, Y., Wu, X., Rice, C. M., Neyts, J., Moradpour, D. and Gouttenoire, J. (2015). Sofosbuvir inhibits Hepatitis E virus replication in vitro and results in an additive effect when combined with ribavirin. Gastroenterology. (Epub ahead of print)
  2. Debing, Y., Emerson, S. U., Purcell, R. H., Neyts, J. and Dallmeier, K. (2014). Complete genome sequence of a rat hepatitis e virus strain isolated in the United States. Genome Announc 2(6).
  3. Debing, Y., Gisa, A., Dallmeier, K., Pischke, S., Bremer, B., Manns, M., Wedemeyer, H., Suneetha, P. V. and Neyts, J. (2014). A mutation in the hepatitis E virus RNA polymerase promotes its replication and associates with ribavirin treatment failure in organ transplant recipients. Gastroenterology 147(5): 1008-1011 e1007; quiz e1015-1006. 
  4. Debing, Y. and Neyts, J. (2014). mTOR-inhibitors may aggravate chronic hepatitis E. J Hepatol 61(4): 720-722.        
  5. Wang, Y., Zhou, X., Debing, Y., Chen, K., Van Der Laan, L. J., Neyts, J., Janssen, H. L., Metselaar, H. J., Peppelenbosch, M. P. and Pan, Q. (2014). Calcineurin inhibitors stimulate and mycophenolic acid inhibits replication of hepatitis E virus. Gastroenterology 146(7): 1775-1783.
  6. Debing, Y. and Neyts, J. (2014). Antiviral strategies for hepatitis E virus. Antiviral Res 102: 106-118.
  7. Debing, Y., Emerson, S. U., Wang, Y., Pan, Q., Balzarini, J., Dallmeier, K. and Neyts, J. (2014). Ribavirin inhibits in vitro hepatitis E virus replication through depletion of cellular GTP pools and is moderately synergistic with alpha interferon. Antimicrob Agents Chemother 58(1): 267-273.
  8. Rocha-Pereira, J., Jochmans, D., Debing, Y., Verbeken, E., Nascimento, M. S. and Neyts, J. (2013). The viral polymerase inhibitor 2'-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model. J Virol 87(21): 11798-11805.
  9. Debing, Y., Winton, J., Neyts, J. and Dallmeier, K. (2013). Cutthroat trout virus as a surrogate in vitro infection model for testing inhibitors of hepatitis E virus replication. Antiviral Res 100(1): 98-101.
  10. Debing, Y., Neyts, J. and Thibaut, H. J. (2013). Molecular Biology and Inhibitors of Hepatitis A Virus. Med Res Rev.
  11. Chatelain, G., Debing, Y., De Burghgraeve, T., Zmurko, J., Saudi, M., Rozenski, J., Neyts, J. and Van Aerschot, A. (2013). In search of flavivirus inhibitors: evaluation of different tritylated nucleoside analogues. Eur J Med Chem 65: 249-255.
  12. Debing, Y., Jochmans, D. and Neyts, J. (2013). Intervention strategies for emerging viruses: use of antivirals. Curr Opin Virol 3(2): 217-224.
  13. Debing, Y., Kaplan, G. G., Neyts, J. and Jochmans, D. (2013). Rapid and convenient assays to assess potential inhibitory activity on in vitro hepatitis A replication. Antiviral Res 98(2): 325-331.
  14. De Burghgraeve, T., Selisko, B., Kaptein, S., Chatelain, G., Leyssen, P., Debing, Y., Jacobs, M., Van Aerschot, A., Canard, B. and Neyts, J. (2013). 3',5'Di-O-trityluridine inhibits in vitro flavivirus replication. Antiviral Res 98(2): 242-247.
Protocols by Yannick Debing
  1. Infectious Virus Yield Assay for Hepatitis E Virus
  2. Luminescence-based Antiviral Assay for Hepatitis E Virus