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Federica Cavallo

Education

Ph. D. in Immunology, University of Torino, Italy, 1994

Current position

Associate professor of Immunology, University of Torino, Italy (2006-present)

Publications (since 2010)

h index: 33, ISI Web of Science Thomson Reuters; the complete list of scientific publications is available at: http://www.researcherid.com/rid/C-5666-2011

  1. Cavallo, F., Aurisicchio, L., Mancini, R. and Ciliberto, G. (2014). Xenogene vaccination in the therapy of cancer. Expert Opin Biol Ther: 1-16.
  2. Riccardo, F., Iussich, S., Maniscalco, L., Lorda-Mayayo, S., La Rosa, G., Arigoni, M., De Maria, R., Gattino, F., Lanzardo, S. and Lardone, E. (2014). CSPG4-specific immunity and survival prolongation in dogs with oral malignant melanoma immunized with human CSPG4 DNA. Clinical Cancer Research: clincanres. 3042.2013.
  3. Masuelli, L., Fantini, M., Benvenuto, M., Sacchetti, P., Giganti, M. G., Tresoldi, I., Lido, P., Lista, F., Cavallo, F., Nanni, P., Schlom, J., Modesti, A. and Bei, R. (2014). Intratumoral delivery of recombinant vaccinia virus encoding for ErbB2/Neu inhibits the growth of salivary gland carcinoma cells. J Transl Med 12: 122.
  4. Riccardo, F., Arigoni, M., Buson, G., Zago, E., Iezzi, M., Longo, D. L., Carrara, M., Fiore, A., Nuzzo, S. and Bicciato, S. (2014). Characterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkers. BMC Genomics 15(3): 1-11.
  5. Macagno, M., Bandini, S., Stramucci, L., Quaglino, E., Conti, L., Balmas, E., Smyth, M. J., Lollini, P. L., Musiani, P., Forni, G., Iezzi, M. and Cavallo, F. (2014). Multiple roles of perforin in hampering ERBB-2 (Her-2/neu) carcinogenesis in transgenic male mice. J Immunol 192(11): 5434-5441.
  6. Occhipinti, S., Sponton, L., Rolla, S., Caorsi, C., Novarino, A., Donadio, M., Bustreo, S., Satolli, M. A., Pecchioni, C., Marchini, C., Amici, A., Cavallo, F., Cappello, P., Pierobon, D., Novelli, F. and Giovarelli, M. (2014). Chimeric rat/human HER2 efficiently circumvents HER2 tolerance in cancer patients. Clin Cancer Res 20(11): 2910-2921.
  7. Bolli, E., Conti, L., Riccardo, F., Marchini, C., Amici, A., Cavallo, F. and Quaglino, E. (2014). Second Ascoli Piceno conference on gene vaccination in cancer (GVC), Ascoli Piceno, Italy, October 9-11, 2013. Cancer Immunol Immunother 63(5): 529-533.
  8. De Giovanni, C., Nicoletti, G., Quaglino, E., Landuzzi, L., Palladini, A., Ianzano, M. L., Dall'Ora, M., Grosso, V., Ranieri, D., Laranga, R., Croci, S., Amici, A., Penichet, M. L., Iezzi, M., Cavallo, F., Nanni, P. and Lollini, P. L. (2014). Vaccines against human HER2 prevent mammary carcinoma in mice transgenic for human HER2. Breast Cancer Res 16(1): R10.
  9. Dentelli, P., Cavallo, F. and Brizzi, M. F. (2014). Membrane-bound KIT ligand-targeting DNA vaccination inhibits mammary tumor growth. Oncoimmunology 3(1): e27259.
  10. Ross, J. A., Spadaro, M., Rosado, D. C., Cavallo, F., Kirken, R. A. and Pericle, F. (2014). Inhibition of JAK3 with a novel, selective and orally active small molecule induces therapeutic response in T-cell malignancies. Leukemia 28(4): 941-944.
  11. Olgasi, C., Dentelli, P., Rosso, A., Iavello, A., Togliatto, G., Toto, V., Liberatore, M., Barutello, G., Musiani, P., Cavallo, F. and Brizzi, M. F. (2014). DNA vaccination against membrane-bound Kit ligand: a new approach to inhibiting tumour growth and angiogenesis. Eur J Cancer 50(1): 234-246.
  12. Spadaro, M., Montone, M., Arigoni, M., Cantarella, D., Forni, G., Pericle, F., Pascolo, S., Calogero, R. A. and Cavallo, F. (2014). Recombinant human lactoferrin induces human and mouse dendritic cell maturation via Toll-like receptors 2 and 4. FASEB J 28(1): 416-429.
  13. Lollini, P. L., Cavallo, F., De Giovanni, C. and Nanni, P. (2013). Preclinical vaccines against mammary carcinoma. Expert Rev Vaccines 12(12): 1449-1463.
  14. Bandini, S., Curcio, C., Macagno, M., Quaglino, E., Arigoni, M., Lanzardo, S., Hysi, A., Barutello, G., Consolino, L., Longo, D. L., Musiani, P., Forni, G., Iezzi, M. and Cavallo, F. (2013). Early onset and enhanced growth of autochthonous mammary carcinomas in C3-deficient Her2/neu transgenic mice. Oncoimmunology 2(9): e26137.
  15. Conti, L., Lanzardo, S., Arigoni, M., Antonazzo, R., Radaelli, E., Cantarella, D., Calogero, R. A. and Cavallo, F. (2013). The noninflammatory role of high mobility group box 1/Toll-like receptor 2 axis in the self-renewal of mammary cancer stem cells. FASEB J 27(12): 4731-4744.
  16. Cordero, F., Beccuti, M., Fornari, C., Lanzardo, S., Conti, L., Cavallo, F., Balbo, G. and Calogero, R. (2013). Multi-level model for the investigation of oncoantigen-driven vaccination effect. BMC Bioinformatics 14 Suppl 6: S11.
  17. Carrara, M., Beccuti, M., Cavallo, F., Donatelli, S., Lazzarato, F., Cordero, F. and Calogero, R. A. (2013). State of art fusion-finder algorithms are suitable to detect transcription-induced chimeras in normal tissues? BMC Bioinformatics 14 Suppl 7: S2.
  18. Marchini, C., Kalogris, C., Garulli, C., Pietrella, L., Gabrielli, F., Curcio, C., Quaglino, E., Cavallo, F. and Amici, A. (2013). Tailoring DNA Vaccines: Designing Strategies Against HER2-Positive Cancers. Front Oncol 3: 122.
  19. Arigoni, M., Barutello, G., Riccardo, F., Ercole, E., Cantarella, D., Orso, F., Conti, L., Lanzardo, S., Taverna, D., Merighi, I., Calogero, R. A., Cavallo, F. and Quaglino, E. (2013). miR-135b coordinates progression of ErbB2-driven mammary carcinomas through suppression of MID1 and MTCH2. Am J Pathol 182(6): 2058-2070.
  20. Carrara, M., Beccuti, M., Lazzarato, F., Cavallo, F., Cordero, F., Donatelli, S. and Calogero, R. A. (2013). State-of-the-art fusion-finder algorithms sensitivity and specificity. Biomed Res Int 2013: 340620.
  21. Conti, L., Lanzardo, S., Iezzi, M., Montone, M., Bolli, E., Brioschi, C., Maiocchi, A., Forni, G. and Cavallo, F. (2013). Optical imaging detection of microscopic mammary cancer in ErbB-2 transgenic mice through the DA364 probe binding alphav beta3 integrins. Contrast Media Mol Imaging 8(4): 350-360.
  22. Ronchi, G., Gambarotta, G., Di Scipio, F., Salamone, P., Sprio, A. E., Cavallo, F., Perroteau, I., Berta, G. N. and Geuna, S. (2013). ErbB2 receptor over-expression improves post-traumatic peripheral nerve regeneration in adult mice. PLoS One 8(2): e56282.
  23. Cappello, P., Rolla, S., Chiarle, R., Principe, M., Cavallo, F., Perconti, G., Feo, S., Giovarelli, M. and Novelli, F. (2013). Vaccination with ENO1 DNA prolongs survival of genetically engineered mice with pancreatic cancer. Gastroenterology 144(5): 1098-1106.
  24. Conzo, G., Mauriello, C., Gambardella, C., Napolitano, S., Cavallo, F., Tartaglia, E. and Santini, L. (2013). Gallstone ileus: One-stage surgery in an elderly patient: One-stage surgery in gallstone ileus. Int J Surg Case Rep 4(3): 316-318.
  25. Iezzi, M., Calogero, R. A., Spadaro, M., Musiani, P., Forni, G. and Cavallo, F. (2012). BALB-neuT female mice as a flexible model of mammary cancer. In: Wang, X. K. (ed). Animal Models of Diseases: Translational Medicine Perspective for Drug Discovery and Development, Chapter 6. Bentham Science Publishers Ltd, 139-166.
  26. Arigoni, M., Barutello, G., Lanzardo, S., Longo, D., Aime, S., Curcio, C., Iezzi, M., Zheng, Y., Barkefors, I., Holmgren, L. and Cavallo, F. (2012). A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors. Angiogenesis 15(2): 305-316.
  27. Burkhardt, U. E., Sloots, A., Jakobi, V., Wei, W. Z., Cavallo, F., Kloke, B. P. and Wels, W. S. (2012). IL-15 augments antitumoral activity of an ErbB2/HER2 cancer vaccine targeted to professional antigen-presenting cells. Cancer Immunol Immunother 61(9): 1473-1484.
  28. Quaglino, E., Riccardo, F., Macagno, M., Bandini, S., Cojoca, R., Ercole, E., Amici, A. and Cavallo, F. (2011). Chimeric DNA Vaccines against ErbB2+ Carcinomas: From Mice to Humans. Cancers (Basel) 3(3): 3225-3241.
  29. Iezzi, M., Quaglino, E., Cappello, P., Toto, V., Sabatini, F., Curcio, C., Garotta, G., Musiani, P. and Cavallo, F. (2011). HCG hastens both the development of mammary carcinoma and the metastatization of HCG/LH and ERBB-2 receptor-positive cells in mice. Int J Immunopathol Pharmacol 24(3): 621-630.
  30. Mayayo, S. L., Prestigio, S., Maniscalco, L., La Rosa, G., Arico, A., De Maria, R., Cavallo, F., Ferrone, S., Buracco, P. and Iussich, S. (2011). Chondroitin sulfate proteoglycan-4: a biomarker and a potential immunotherapeutic target for canine malignant melanoma. Vet J 190(2): e26-30.
  31. Riganti, C., Pinto, H., Bolli, E., Belisario, D. C., Calogero, R. A., Bosia, A. and Cavallo, F. (2011). Atorvastatin modulates anti-proliferative and pro-proliferative signals in Her2/neu-positive mammary cancer. Biochem Pharmacol 82(9): 1079-1089.
  32. Berta, G. N., Sprio, A. E., Iezzi, M., Spadaro, M., Cappia, S., Salamone, P., Di Scipio, F., Mognetti, B., Papotti, M., Musiani, P., Forni, G. and Cavallo, F. (2011). A DNA vaccine against ERBB2 impairs chemical carcinogenesis in random-bred hamsters. Cancer Prev Res (Phila) 4(7): 994-1001.
  33. Cavallo, F., De Giovanni, C., Nanni, P., Forni, G. and Lollini, P. L. (2011). 2011: the immune hallmarks of cancer. Cancer Immunol Immunother 60(3): 319-326.
  34. Noris, E., Poli, A., Cojoca, R., Ritta, M., Cavallo, F., Vaglio, S., Matic, S. and Landolfo, S. (2011). A human papillomavirus 8 E7 protein produced in plants is able to trigger the mouse immune system and delay the development of skin lesions. Arch Virol 156(4): 587-595.
  35. Lollini, P. L., Nicoletti, G., Landuzzi, L., Cavallo, F., Forni, G., De Giovanni, C. and Nanni, P. (2011). Vaccines and other immunological approaches for cancer immunoprevention. Curr Drug Targets 12(13): 1957-1973.
  36. Bolli, E., Quaglino, E., Arigoni, M., Lollini, P. L., Calogero, R., Forni, G. and Cavallo, F. (2011). Oncoantigens for an immune prevention of cancer. Am J Cancer Res 1(2): 255-264.
  37. Triulzi, C., Vertuani, S., Curcio, C., Antognoli, A., Seibt, J., Akusjarvi, G., Wei, W. Z., Cavallo, F. and Kiessling, R. (2010). Antibody-dependent natural killer cell-mediated cytotoxicity engendered by a kinase-inactive human HER2 adenovirus-based vaccination mediates resistance to breast tumors. Cancer Res 70(19): 7431-7441.
  38. Rolla, S., Ria, F., Occhipinti, S., Di Sante, G., Iezzi, M., Spadaro, M., Nicolo, C., Ambrosino, E., Merighi, I. F., Musiani, P., Forni, G. and Cavallo, F. (2010). Erbb2 DNA vaccine combined with regulatory T cell deletion enhances antibody response and reveals latent low-avidity T cells: potential and limits of its therapeutic efficacy. J Immunol 184(11): 6124-6132.
  39. Porzia, A., Lanzardo, S., Citti, A., Cavallo, F., Forni, G., Santoni, A., Galandrini, R. and Paolini, R. (2010). Attenuation of PI3K/Akt-mediated tumorigenic signals through PTEN activation by DNA vaccine-induced anti-ErbB2 antibodies. J Immunol 184(8): 4170-4177.
  40. Quaglino, E., Mastini, C., Amici, A., Marchini, C., Iezzi, M., Lanzardo, S., De Giovanni, C., Montani, M., Lollini, P. L., Masucci, G., Forni, G. and Cavallo, F. (2010). A better immune reaction to Erbb-2 tumors is elicited in mice by DNA vaccines encoding rat/human chimeric proteins. Cancer Res 70(7): 2604-2612.
  41. Barbieri, I., Pensa, S., Pannellini, T., Quaglino, E., Maritano, D., Demaria, M., Voster, A., Turkson, J., Cavallo, F., Watson, C. J., Provero, P., Musiani, P. and Poli, V. (2010). Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten. Cancer Res 70(6): 2558-2567.
  42. Barbieri, I., Quaglino, E., Maritano, D., Pannellini, T., Riera, L., Cavallo, F., Forni, G., Musiani, P., Chiarle, R. and Poli, V. (2010). Stat3 is required for anchorage-independent growth and metastasis but not for mammary tumor development downstream of the ErbB-2 oncogene. Mol Carcinog 49(2): 114-120.
  43. Coscia, M., Quaglino, E., Iezzi, M., Curcio, C., Pantaleoni, F., Riganti, C., Holen, I., Monkkonen, H., Boccadoro, M., Forni, G., Musiani, P., Bosia, A., Cavallo, F. and Massaia, M. (2010). Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. J Cell Mol Med 14(12): 2803-2815.
Protocols by Federica Cavallo
  1. Generation and Maturation of Human Monocyte-derived DCs