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Michela Spadaro


Ph.D. in Immunology and Cellular Biology, University of Turin, 2006

Current position

Researcher at the University Hospital San Luigi Gonzaga of Orbassano, Turin (2013-present)


  1. Spadaro, M., Montone, M., Arigoni, M., Cantarella, D., Forni, G., Pericle, F., Pascolo, S., Calogero, R. A. and Cavallo, F. (2014). Recombinant human lactoferrin induces human and mouse dendritic cell maturation via Toll-like receptors 2 and 4. FASEB J 28(1): 416-429.
  2. Ross, J. A., Spadaro, M., Rosado, D. C., Cavallo, F., Kirken, R. A. and Pericle, F. (2014). Inhibition of JAK3 with a novel, selective and orally active small molecule induces therapeutic response in T-cell malignancies. Leukemia 28(4): 941-944.
  3. Tornillo, G., Elia, A. R., Castellano, I., Spadaro, M., Bernabei, P., Bisaro, B., Camacho-Leal Mdel, P., Pincini, A., Provero, P., Sapino, A., Turco, E., Defilippi, P. and Cabodi, S. (2013). p130Cas alters the differentiation potential of mammary luminal progenitors by deregulating c-Kit activity. Stem Cells 31(7): 1422-1433.
  4. Iezzi, M., Calogero, R. A., Spadaro, M., Musiani, P., Forni, G. and Cavallo, F. (2012). BALB-neuT female mice as a flexible model of mammary cancer. In: Wang, X. K. (ed). Animal Models of Diseases: Translational Medicine Perspective for Drug Discovery and Development, Chapter 6. Bentham Science Publishers Ltd, 139-166.
  5. Berta, G. N., Sprio, A. E., Iezzi, M., Spadaro, M., Cappia, S., Salamone, P., Di Scipio, F., Mognetti, B., Papotti, M., Musiani, P., Forni, G. and Cavallo, F. (2011). A DNA vaccine against ERBB2 impairs chemical carcinogenesis in random-bred hamsters. Cancer Prev Res (Phila) 4(7): 994-1001.
  6. Rolla, S., Ria, F., Occhipinti, S., Di Sante, G., Iezzi, M., Spadaro, M., Nicolo, C., Ambrosino, E., Merighi, I. F., Musiani, P., Forni, G. and Cavallo, F. (2010). Erbb2 DNA vaccine combined with regulatory T cell deletion enhances antibody response and reveals latent low-avidity T cells: potential and limits of its therapeutic efficacy. J Immunol 184(11): 6124-6132.
  7. Delli Castelli, D., Dastru, W., Terreno, E., Cittadino, E., Mainini, F., Torres, E., Spadaro, M. and Aime, S. (2010). In vivo MRI multicontrast kinetic analysis of the uptake and intracellular trafficking of paramagnetically labeled liposomes. J Control Release 144(3): 271-279.
  8. Spadaro, M., Caorsi, C., Ceruti, P., Varadhachary, A., Forni, G., Pericle, F. and Giovarelli, M. (2008). Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells. FASEB J 22(8): 2747-2757.
  9. Curcio, C., Khan, A. S., Amici, A., Spadaro, M., Quaglino, E., Cavallo, F., Forni, G. and Draghia-Akli, R. (2008). DNA immunization using constant-current electroporation affords long-term protection from autochthonous mammary carcinomas in cancer-prone transgenic mice. Cancer Gene Ther 15(2): 108-114.
  10. Spadaro, M., Curcio, C., Varadhachary, A., Cavallo, F., Engelmayer, J., Blezinger, P., Pericle, F. and Forni, G. (2007). Requirement for IFN-gamma, CD8+ T lymphocytes, and NKT cells in talactoferrin-induced inhibition of neu+ tumors. Cancer Res 67(13): 6425-6432.
  11. Ambrosino, E.*, Spadaro, M.*, Iezzi, M., Curcio, C., Forni, G., Musiani, P., Wei, W. Z. and Cavallo, F. (2006). Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance. Cancer Res 66(15): 7734-7740.
  12. Pannellini, T., Spadaro, M., Di Carlo, E., Ambrosino, E., Iezzi, M., Amici, A., Lollini, P. L., Forni, G., Cavallo, F. and Musiani, P. (2006). Timely DNA vaccine combined with systemic IL-12 prevents parotid carcinomas before a dominant-negative p53 makes their growth independent of HER-2/neu expression. J Immunol 176(12): 7695-7703.
  13. Spadaro, M., Ambrosino, E., Iezzi, M., Di Carlo, E., Sacchetti, P., Curcio, C., Amici, A., Wei, W. Z., Musiani, P., Lollini, P. L., Cavallo, F. and Forni, G. (2005). Cure of mammary carcinomas in Her-2 transgenic mice through sequential stimulation of innate (neoadjuvant interleukin-12) and adaptive (DNA vaccine electroporation) immunity. Clin Cancer Res 11(5): 1941-1952.
  14. Berta, G. N., Mognetti, B., Spadaro, M., Trione, E., Amici, A., Forni, G., Di Carlo, F. and Cavallo, F. (2005). Anti-HER-2 DNA vaccine protects Syrian hamsters against squamous cell carcinomas. Br J Cancer 93(11): 1250-1256.
  15. Varadhachary, A., Wolf, J. S., Petrak, K., O'Malley, B. W., Jr., Spadaro, M., Curcio, C., Forni, G. and Pericle, F. (2004). Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy. Int J Cancer 111(3): 398-403.
  16. Quaglino, E., Iezzi, M., Mastini, C., Amici, A., Pericle, F., Di Carlo, E., Pupa, S. M., De Giovanni, C., Spadaro, M., Curcio, C., Lollini, P. L., Musiani, P., Forni, G. and Cavallo, F. (2004). Electroporated DNA vaccine clears away multifocal mammary carcinomas in her-2/neu transgenic mice. Cancer Res 64(8): 2858-2864.
  17. Quaglino, E., Rolla, S., Iezzi, M., Spadaro, M., Musiani, P., De Giovanni, C., Lollini, P. L., Lanzardo, S., Forni, G., Sanges, R., Crispi, S., De Luca, P., Calogero, R. and Cavallo, F. (2004). Concordant morphologic and gene expression data show that a vaccine halts HER-2/neu preneoplastic lesions. J Clin Invest 113(5): 709-717.
  18. Spadaro, M., Lanzardo, S., Curcio, C., Forni, G. and Cavallo, F. (2004). Immunological inhibition of carcinogenesis. Cancer Immunol Immunother 53(3): 204-216.
  19. Spadaro, M. and Forni, G. (2004). Proinflammatory cytokines, immune response and tumour progression. Novartis Foundation symposium, Chichester; New York; John Wiley; 1999.
  20. Forni, G., Curcio, C., Spadaro, M., Iliffe, J., Quaglino, E., Di Carlo, E., Musiani, P. and Lollini, P. L. (2003). Immunization in tumor prevention. Int Immunopharmacol 3(8): 1151-1158.
  21. Curcio, C., Di Carlo, E., Clynes, R., Smyth, M. J., Boggio, K., Quaglino, E., Spadaro, M., Colombo, M. P., Amici, A., Lollini, P. L., Musiani, P. and Forni, G. (2003). Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas. J Clin Invest 111(8): 1161-1170.
  22. Cifaldi, L., Quaglino, E., Di Carlo, E., Musiani, P., Spadaro, M., Lollini, P. L., Wolf, S., Boggio, K., Forni, G. and Cavallo, F. (2001). A light, nontoxic interleukin 12 protocol inhibits HER-2/neu mammary carcinogenesis in BALB/c transgenic mice with established hyperplasia. Cancer Res 61(7): 2809-2812.

    *Equally contributed
Protocols by Michela Spadaro
  1. Generation and Maturation of Human Monocyte-derived DCs