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Shanie   Saghafian-Hedengren

Shanie Saghafian-Hedengren


Ph.D. in Immunology, Deparment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Sweden, 2009

Current position

Postdoctoral scholar, Clinical Paediatrics, Karolinska Institute, Stockholm, Sweden


  1. Sohlberg, E., Saghafian-Hedengren, S., Bachmayer, N., Hamad, R. R., Bremme, K. and Holmlund, U. (2014). Pre-eclampsia affects cord blood NK cell expression of activation receptors and serum cytokine levels but not CB monocyte characteristics. Am J Reprod Immunol 71(2): 178-188.
  2. Bemark, M., Friskopp, L., Saghafian-Hedengren, S., Koethe, S., Fasth, A., Abrahamsson, J., Sverremark-Ekstrom, E., Andersson, B. A. and Mellgren, K. (2013). A glycosylation-dependent CD45RB epitope defines previously unacknowledged CD27(-)IgM(high) B cell subpopulations enriched in young children and after hematopoietic stem cell transplantation. Clin Immunol 149(3): 421-431.
  3. Sohlberg, E., Saghafian-Hedengren, S., Rasul, E., Marchini, G., Nilsson, C., Klein, E., Nagy, N. and Sverremark-Ekstrom, E. (2013). Cytomegalovirus-seropositive children show inhibition of in vitro EBV infection that is associated with CD8+CD57+ T cell enrichment and IFN-gamma. J Immunol 191(11): 5669-5676.
  4. Saghafian-Hedengren, S., Sohlberg, E., Theorell, J., Carvalho-Queiroz, C., Nagy, N., Persson, J. O., Nilsson, C., Bryceson, Y. T. and Sverremark-Ekstrom, E. (2013). Epstein-Barr virus coinfection in children boosts cytomegalovirus-induced differentiation of natural killer cells. J Virol 87(24): 13446-13455.
  5. Johansson, M. A., Saghafian-Hedengren, S., Haileselassie, Y., Roos, S., Troye-Blomberg, M., Nilsson, C. and Sverremark-Ekstrom, E. (2012). Early-life gut bacteria associate with IL-4-, IL-10- and IFN-gamma production at two years of age. PLoS One 7(11): e49315.
  6. Simon, K. C., Saghafian-Hedengren, S., Sverremark-Ekström, E., Nilsson, C. and Ascherio, A. (2012). Age at Epstein-Barr virus infection and Epstein-Barr virus nuclear antigen-1 antibodies in Swedish children. Multiple Sclerosis and Related Disorders 1(3): 136-138.
  7. Sohlberg, E., Saghafian-Hedengren, S., Bremme, K. and Sverremark-Ekstrom, E. (2011). Cord blood monocyte subsets are similar to adult and show potent peptidoglycan-stimulated cytokine responses. Immunology 133(1): 41-50.
  8. Saghafian-Hedengren, S., Sverremark-Ekstrom, E., Linde, A., Lilja, G. and Nilsson, C. (2010). Early-life EBV infection protects against persistent IgE sensitization. J Allergy Clin Immunol 125(2): 433-438.
  9. Saghafian-Hedengren, S., Sundstrom, Y., Sohlberg, E., Nilsson, C., Linde, A., Troye-Blomberg, M., Berg, L. and Sverremark-Ekstrom, E. (2009). Herpesvirus seropositivity in childhood associates with decreased monocyte-induced NK cell IFN-gamma production. J Immunol 182(4): 2511-2517.
  10. Amoudruz, P., Holmlund, U., Saghafian-Hedengren, S., Nilsson, C. and Sverremark-Ekstrom, E. (2009). Impaired Toll-like receptor 2 signalling in monocytes from 5-year-old allergic children. Clin Exp Immunol 155(3): 387-394.
  11. Saghafian-Hedengren, S., Holmlund, U., Amoudruz, P., Nilsson, C. and Sverremark-Ekstrom, E. (2008). Maternal allergy influences p38-mitogen-activated protein kinase activity upon microbial challenge in CD14+ monocytes from 2-year-old children. Clin Exp Allergy 38(3): 449-457.
Protocols by Shanie Saghafian-Hedengren
  1. In vitro EBV Infection of Mononuclear Cells that Have Been Cryo-preserved