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Joni H. Ylostalo


Ph.D. in Biomedical Sciences, Tulane University School of Medicine, New Orleans, LA, 2008

Current position

Instructor, Institute for Regenerative Medicine, Texas A&M Health Science Center COM, Temple, TX
Adjunct Instructor, Department of Biology, University of Mary Hardin-Baylor, Belton, TX


  1. Bartosh, T. J. and Ylostalo, J. H. (2014). Preparation of anti-inflammatory mesenchymal stem/precursor cells (MSCs) through sphere formation using hanging-drop culture technique. Curr Protoc Stem Cell Biol 28: Unit 2B 6.
  2. Bartosh, T. J.*, Ylostalo, J. H.*, Bazhanov, N., Kuhlman, J. and Prockop, D. J. (2013). Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1). Stem Cells 31(11): 2443-2456.
  3. Ylöstalo, J. H. and Bartosh, T. J. (2013). Mesenchymal Stem Cells Characteristics, Niches, and Applications for Cell Therapy. Volume (2): 429-470.
  4. Ylostalo, J. H.*, Bartosh, T. J.*, Coble, K. and Prockop, D. J. (2012).Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype. Stem Cells 30(10): 2283-2296.
  5.  Horie, M., Choi, H., Lee, R. H., Reger, R. L., Ylostalo, J., Muneta, T., Sekiya, I. and Prockop, D. J. (2012). Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen.  Osteoarthritis Cartilage 20(10): 1197-1207.
  6.  Oh, J. Y., Choi, H., Lee, R. H., Roddy, G. W., Ylöstalo, J. H., Wawrousek, E. and Prockop, D. J. (2012). Identification of the HSPB4/TLR2/NFκB axis in macrophage as a therapeutic target for sterile inflammation of the cornea. EMBO molecular medicine 4(5): 435-448.
  7.  Roddy, G. W., Rosa, R. H., Jr., Oh, J. Y., Ylostalo, J. H., Bartosh, T. J., Jr., Choi, H., Lee, R. H., Yasumura, D., Ahern, K., Nielsen, G., Matthes, M. T., LaVail, M. M. and Prockop, D. J. (2012). Stanniocalcin-1 rescued photoreceptor degeneration in two rat models of inherited retinal degeneration. Mol Ther 20(4): 788-797.
  8. Foraker, J. E., Oh, J. Y., Ylostalo, J. H., Lee, R. H., Watanabe, J. and Prockop, D. J. (2011). Crosstalk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPSstimulated cocultures: the MSCs are activated to secrete prostaglandin E2. Journal of neurochemistry 119(5): 1052-1063.
  9.  Roddy, G. W., Oh, J. Y., Lee, R. H., Bartosh, T. J., Ylostalo, J., Coble, K., Rosa, R. H. and Prockop, D. J. (2011).  Action at a Distance: Systemically Administered Adult Stem/Progenitor Cells (MSCs) Reduce Inflammatory Damage to the Cornea Without Engraftment and Primarily by Secretion of TNFα Stimulated Gene/Protein 6. Stem Cells 29(10): 1572-1579.
  10.  Danchuk, S., Ylostalo, J. H., Hossain, F., Sorge, R., Ramsey, A., Bonvillain, R. W., Lasky, J. A., Bunnell, B. A., Welsh, D. A., Prockop, D. J. and Sullivan, D. E. (2011).  Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-alpha-induced protein 6. Stem Cell Res Ther 2(3): 27.
  11. Oh, J. Y., Roddy, G. W., Choi, H., Lee, R. H., Ylostalo, J. H., Rosa, R. H., Jr. and Prockop, D. J. (2010). Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury. Proc Natl Acad Sci U S A 107(39): 16875-16880.
  12. Fresquet, M., Jowitt, T. A., Stephen, L. A., Ylöstalo, J. and Briggs, M. D. (2010).  Structural and functional investigations of Matrilin-1 A-domains reveal insights into their role in cartilage ECM assembly. Journal of Biological Chemistry 285(44): 34048-34061.
  13.  Bartosh, T. J.*, Ylostalo, J. H.*, Mohammadipoor, A., Bazhanov, N., Coble, K., Claypool, K., Lee, R. H., Choi, H. and Prockop, D. J. (2010).  Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties. Proc Natl Acad Sci U S A 107(31): 13724-13729.
  14. Larson, B. L., Ylostalo, J., Lee, R. H., Gregory, C. and Prockop, D. J. (2010). Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells. Tissue engineering Part A 16(11): 3385-3394.
  15.  Robinson, A. P., Foraker, J. E., Ylostalo, J. and Prockop, D. J. (2011). Human stem/progenitor cells from bone marrow enhance glial differentiation of rat neural stem cells: a role for transforming growth factor beta and Notch signaling. Stem Cells Dev 20(2): 289-300.
  16.  Krause, U., Harris, S., Green, A., Ylostalo, J., Zeitouni, S., Lee, N. and Gregory, C. A. (2010). Pharmaceutical modulation of canonical Wnt signaling in multipotent stromal cells for improved osteoinductive therapy. Proc Natl Acad Sci U S A 107(9): 4147-4152.
  17.  Bakondi, B., Shimada, I. S., Perry, A., Munoz, J. R., Ylostalo, J., Howard, A. B., Gregory, C. A. and Spees, J. L. (2009). CD133 identifies a human bone marrow stem/progenitor cell sub-population with a repertoire of secreted factors that protect against stroke. Mol Ther 17(11): 1938-1947.
  18.  Lee, R. H., Pulin, A. A., Seo, M. J., Kota, D. J., Ylostalo, J., Larson, B. L., Semprun-Prieto, L., Delafontaine, P. and Prockop, D. J. (2009). Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell stem cell 5(1): 54-63.
    *Equal contribution
Protocols by Joni H. Ylostalo
  1. Mesenchymal Stem Cell (MSC) Aggregate Formation in vivo
  2. Macrophage Inflammatory Assay