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Thomas  J.  Bartosh

Thomas J. Bartosh


Ph.D. in Biomedical Sciences, Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth, TX, 2008

Current position

Assistant Professor, Institute for Regenerative Medicine, Texas A&M University Health Science Center, Temple, TX
Flow Cytometry/Microscopy Core Supervisor, Institute for Regenerative Medicine, Texas A&M University Health Science Center, Temple, TX


  1. Bartosh, T. J. and Ylostalo, J. H. (2014). Preparation of anti-inflammatory mesenchymal stem/precursor cells (MSCs) through sphere formation using hanging-drop culture technique. Curr Protoc Stem Cell Biol 28: Unit 2B 6.
  2.  Wang, Z., Bartosh, T. J., Ding, M. and Roque, R. S. (2014). MAPKs Modulate RPE Response to Oxidative Stress. Journal of Medical and Bioengineering Vol 3(1):67-73.
  3. Foskett, A. M., Bazhanov, N., Ti, X., Tiblow, A., Bartosh, T. J. and Prockop, D. J. (2014). Phase-directed therapy: TSG-6 targeted to early inflammation improves bleomycin-injured lungs. Am J Physiol Lung Cell Mol Physiol 306(2): L120-131.
  4. Bartosh, T. J., Ylostalo, J. H., Bazhanov, N., Kuhlman, J. and Prockop, D. J. (2013). Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1). Stem Cells 31(11): 2443-2456.
  5. Ylöstalo, J. H. and Bartosh, T. J. (2013). Mesenchymal Stem Cells Characteristics, Niches, and Applications for Cell Therapy. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Volume (2): 429-470.
  6. Ylostalo, J. H., Bartosh, T. J., Coble, K. and Prockop, D. J. (2012). Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype. Stem Cells 30(10): 2283-2296.
  7. Roddy, G. W., Rosa Jr, R. H., Oh, J. Y., Ylostalo, J. H., Bartosh, T. J., Choi, H., Lee, R. H., Yasumura, D., Ahern, K. and Nielsen, G. (2012). Stanniocalcin-1 rescued photoreceptor degeneration in two rat models of inherited retinal degeneration. Molecular Therapy 20(4): 788-797.
  8. Roddy, G. W., Oh, J. Y., Lee, R. H., Bartosh, T. J., Ylostalo, J., Coble, K., Rosa, R. H. and Prockop, D. J. (2011). Action at a Distance: Systemically Administered Adult Stem/Progenitor Cells (MSCs) Reduce Inflammatory Damage to the Cornea Without Engraftment and Primarily by Secretion of TNF‐α Stimulated Gene/Protein 6. Stem Cells 29(10): 1572-1579.
  9. Bartosh, T. J., Ylostalo, J. H., Mohammadipoor, A., Bazhanov, N., Coble, K., Claypool, K., Lee, R. H., Choi, H. and Prockop, D. J. (2010). Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties. Proc Natl Acad Sci U S A 107(31): 13724-13729.
  10. Bartosh, T. J., Wang, Z., Rosales, A. A., Dimitrijevich, S. D. and Roque, R. S. (2008). 3D-model of adult cardiac stem cells promotes cardiac differentiation and resistance to oxidative stress. J Cell Biochem 105(2): 612-623.
  11. Sheedlo, H. J., Bartosh, T. J., Wang, Z., Srinivasan, B., Brun-Zinkernagel, A. M. and Roque, R. S. (2007). RPE-derived factors modulate photoreceptor differentiation: a possible role in the retinal stem cell niche. In Vitro Cell Dev Biol Anim 43(10): 361-370.
Protocols by Thomas J. Bartosh
  1. Mesenchymal Stem Cell (MSC) Aggregate Formation in vivo
  2. Macrophage Inflammatory Assay