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Marc-Antoine Sani

Education

Ph.D. in Physical Chemistry, Umeå University (Sweden)/Bordeaux University (France), 2008

Current position

Research Fellow, Level B, School of Chemistry, Bio21 Institute, University of Melbourne, Australia

Publications

Book chapters

  1. Sani, M. A. and Separovic, F. (2014). Solid-state NMR studies of frog antimicrobial peptide interactions with specific lipid environments in advances in biological solid-state NMR: Proteins and membrane-active peptides. In: Separovic, F. and Naito, A. (eds). RSC Books, 287-303.
  2. Gehman, J. D., Sani, M. A. and Separovic, S. (2010). Solid-state NMR of membrane-acting antimicrobial peptides in Advances in Biomedical Spectroscopy: Biomolecular NMR Spectroscopy. In: Dingley, A. J. and Pascal, S. M. (eds). IOS Press, 137-161.

Refereed journal articles

  1. Li, W., Sani, M. A., Jamasbi, E., Otvos, L., Jr., Hossain, M. A., Wade, J. D. and Separovic, F. (2016). Membrane interactions of proline-rich antimicrobial peptide, Chex1-Arg20, multimers. Biochim Biophys Acta 1858(6): 1236-1243.
  2. Walkley, B., San Nicolas, R., Sani, M. A., Gehman, J. D., van Deventer, J. S. and Provis, J. L. (2016). Phase evolution of Na2O-Al2O3-SiO2-H2O gels in synthetic aluminosilicate binders. Dalton Trans 45(13): 5521-5535.
  3. Lau, C. H., Mulet, X., Konstas, K., Doherty, C. M., Sani, M. A., Separovic, F., Hill, M. R. and Wood, C. D. (2016). Hypercrosslinked Additives for Ageless Gas-Separation Membranes. Angew Chem Int Ed Engl 55(6): 1998-2001.
  4. Sani, M. A.*, Henriques, S. T., Weber, D. and Separovic, F. (2015). Bacteria May Cope Differently from Similar Membrane Damage Caused by the Australian Tree Frog Antimicrobial Peptide Maculatin 1.1. J Biol Chem 290(32): 19853-19862.(*Corresponding author)
  5. Sani, M. A., Lee, T. H., Aguilar, M. I. and Separovic, F. (2015). Proline-15 creates an amphipathic wedge in maculatin 1.1 peptides that drives lipid membrane disruption. Biochim Biophys Acta 1848(10 Pt A): 2277-2289.
  6. Henriques, S. T., Huang, Y. H., Chaousis, S., Sani, M. A., Poth, A. G., Separovic, F. and Craik, D. J. (2015). The Prototypic Cyclotide Kalata B1 Has a Unique Mechanism of Entering Cells. Chem Biol 22(8): 1087-1097.
  7. Garcia, A., Eljack, N. D., Sani, M. A., Separovic, F., Rasmussen, H. H., Kopec, W., Khandelia, H., Cornelius, F. and Clarke, R. J. (2015). Membrane accessibility of glutathione. Biochim Biophys Acta 1848(10 Pt A): 2430-2436.
  8. Sani, M. A. and Separovic, F. (2015). Progression of NMR studies of membrane-active peptides from lipid bilayers to live cells. J Magn Reson 253: 138-142.
  9. Jamasbi, E., Batinovic, S., Sharples, R. A., Sani, M. A., Robins-Browne, R. M., Wade, J. D., Separovic, F. and Hossain, M. A. (2014). Melittin peptides exhibit different activity on different cells and model membranes. Amino Acids 46(12): 2759-2766.
  10. Sani, M. A., Gagne, E., Gehman, J. D., Whitwell, T. C. and Separovic, F. (2014). Dye-release assay for investigation of antimicrobial peptide activity in a competitive lipid environment. Eur Biophys J 43(8-9): 445-450.
  11. Weber, D. K., Sani, M. A. and Gehman, J. D. (2014). A routine method for cloning, expressing and purifying Aβ(1-42) for structural NMR studies. Amino Acids 46(10): 2415-2426.
  12. Luna-Ramirez, K., Sani, M. A., Silva-Sanchez, J., Jimenez-Vargas, J. M., Reyna-Flores, F., Winkel, K. D., Wright, C. E., Possani, L. D. and Separovic, F. (2014). Membrane interactions and biological activity of antimicrobial peptides from Australian scorpion. Biochim Biophys Acta 1838(9): 2140-2148.
  13. Sani, M. A.*, Whitwell, T. C., Gehman, J. D., Robins-Browne, R. M., Pantarat, N., Attard, T. J., Reynolds, E. C., O'Brien-Simpson, N. M. and Separovic, F. (2013). Maculatin 1.1 disrupts Staphylococcus aureus lipid membranes via a pore mechanism. Antimicrob Agents Chemother 57(8): 3593-3600. (*Corresponding author)
  14. Mukherjee, T., Sani, M., Kao, K., Gupta, R. K., Quazi, N. and Bhattacharya, S. (2013). Improved dispersion of cellulose microcrystals in polylactic acid (PLA) based composites applying surface acetylation. Chem Eng Sci 101:655-662.
  15. Fernandez, D. I., Sani, M. A., Miles, A. J., Wallace, B. A. and Separovic, F. (2013). Membrane defects enhance the interaction of antimicrobial peptides, aurein 1.2 versus caerin 1.1. Biochim Biophys Acta 1828(8): 1863-1872.
  16. Fernandez, D. I., Lee, T. H., Sani, M. A., Aguilar, M. I. and Separovic, F. (2013). Proline facilitates membrane insertion of the antimicrobial peptide maculatin 1.1 via surface indentation and subsequent lipid disordering. Biophys J 104(7): 1495-1507.
  17. Sani, M. A., Weber, D. K., Delaglio, F., Separovic, F. and Gehman, J. D. (2013). A practical implementation of de-Pake-ing via weighted Fourier transformation. PeerJ 1: e30.
  18. Dufourc, E. J., Buchoux, S., Toupe, J., Sani, M. A., Jean-Francois, F., Khemtemourian, L., Grelard, A., Loudet-Courreges, C., Laguerre, M., Elezgaray, J., Desbat, B. and Odaert, B. (2012). Membrane interacting peptides: from killers to helpers. Curr Protein Pept Sci 13(7): 620-631.
  19. Fernandez, D. I., Le Brun, A. P., Whitwell, T. C., Sani, M. A., James, M. and Separovic, F. (2012). The antimicrobial peptide aurein 1.2 disrupts model membranes via the carpet mechanism. Phys Chem Chem Phys 14(45): 15739-15751.
  20. Weber, K., Separovic, F., Gehman, J. and Sani, M. A.* (2012). Copper modulation of amyloid beta 42 interactions with model membranes. Aust J Chem 65(5):472-479. (*Corresponding author)
  21. Sani, M. A.*, Separovic, F. and Gehman, J. (2012). The lipid network. Biophys. Reviews, 4(4):283-290. (*Corresponding author)
  22. Sani, M. A., Whitwell, T. C. and Separovic, F. (2012). Lipid composition regulates the conformation and insertion of the antimicrobial peptide maculatin 1.1. Biochim Biophys Acta 1818(2): 205-211.
  23. Fernandez, D. I., Sani, M. A. and Separovic, F. (2011). Interactions of the antimicrobial peptide maculatin 1.1 and analogues with phospholipid bilayers. Aust J Chem 64:798-805.
  24. Sani, M. A., Separovic, F. and Gehman, J. D. (2011). Disentanglement of heterogeneous dynamics in mixed lipid systems. Biophys J 100(8): L40-42.
  25. Sani, M. A., Gehman, J. D. and Separovic, F. (2011). Lipid matrix plays a role in Abeta fibril kinetics and morphology. FEBS Lett 585(5): 749-754.
  26. Fernandez, D. I., Sani, M. A., Gehman, J. D., Hahm, K. S. and Separovic, F. (2011). Interactions of a synthetic Leu-Lys-rich antimicrobial peptide with phospholipid bilayers. Eur Biophys J 40(4): 471-480.
  27. Sani, M. A.*, Keech, O., Gardestrom, P., Dufourc, E. J. and Grobner, G. (2009). Magic-angle phosphorus NMR of functional mitochondria: in situ monitoring of lipid response under apoptotic-like stress. FASEB J 23(9): 2872-2878. (*Corresponding author)
  28. Sani, M. A., Dufourc, E. J. and Grobner, G. (2009). How does the Bax-α1 targeting sequence interact with mitochondrial membranes? The role of cardiolipin. Biochim Biophys Acta 1788(3): 623-631.
  29. Bystrom, R., Aisenbrey, C., Borowik, T., Bokvist, M., Lindstrom, F., Sani, M. A., Olofsson, A. and Grobner, G. (2008). Disordered proteins: biological membranes as two-dimensional aggregation matrices. Cell Biochem Biophys 52(3): 175-189.
  30. Sani, M. A., Castano, S., Dufourc, E. J. and Grobner, G. (2008). Restriction of lipid motion in membranes triggered by β-sheet aggregation of the anti-apoptotic BH4 domain. FEBS J 275(3): 561-572.
  31. Aisenbrey, C., Borowik, T., Bystrom, R., Bokvist, M., Lindstrom, F., Misiak, H., Sani, M. A. and Grobner, G. (2008). How is protein aggregation in amyloidogenic diseases modulated by biological membranes? Eur Biophys J 37(3): 247-255.
  32. Sani, M. A., Loudet, C., Grobner, G. and Dufourc, E. J. (2007). Pro-apoptotic bax-α1 synthesis and evidence for β-sheet to alpha-helix conformational change as triggered by negatively charged lipid membranes. J Pept Sci 13(2): 100-106.
  33. Khemtemourian, L., Sani, M. A., Bathany, K., Grobner, G. and Dufourc, E. J. (2006). Synthesis and secondary structure in membranes of the Bcl-2 anti-apoptotic domain BH4. J Pept Sci 12(1): 58-64.

Other research outputs

  1. Gehman, J., Sani, M. A. (2012). Antimicrobial peptides: Agent of public health. Aust Biochemist 43(2):13-16.
  2. Sani, M., O’Brien-Simpson, N. M. and Separovic, F. (2014). Dye release experiments with dextran loaded vesicles. Bio-protocol 4(14): e1190.
  3. O’Brien-Simpson, N. M., Pantarat, N., Walsh, K. A., Reynolds, E. C., Sani, M. and Separovic, F. (2014). Bacterial dluorescent-dextran diffusion assay. Bio-protocol 4(14): e1191.
Protocols by Marc-Antoine Sani
  1. Bacterial Fluorescent-dextran Diffusion Assay
  2. Dye Release Experiments with Dextran Loaded Vesicles