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Guo-Ping Zhao

Education

Ph.D. in Biochemistry, Department of Biochemistry, Purdue University, USA, 1990

Current position

Professor, Department of Microbiology, Faculty of Medicine, Li Ka Shing Institute of Health Sciences, the Chinese University of Hong Kong
Professor and Director, CAS-Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology (IPPE), Shanghai Institutes for Biological Sciences (SIBS) Chinese Academy of Sciences (CAS)

Publications (representative Publications)

  1. Lyu, L. D., Tang, B. K., Fan, X. Y., Ma, H. and Zhao, G. P.* (2013). Mycobacterial MazG safeguards genetic stability via housecleaning of 5-OH-dCTP. PLoS Pathog 9(12): e1003814.
  2. Wang, Y., Cen, X. F., Zhao, G. P.* and Wang, J. (2012). Characterization of a new GlnR binding box in the promoter of amtB in Streptomyces coelicolor inferred a PhoP/GlnR competitive binding mechanism for transcriptional regulation of amtB. J Bacteriol 194(19): 5237-5244.
  3. Zhao, W., Zhong, Y., Yuan, H., Wang, J., Zheng, H., Wang, Y., Cen, X., Xu, F., Bai, J., Han, X., Lu, G., Zhu, Y., Shao, Z., Yan, H., Li, C., Peng, N., Zhang, Z., Zhang, Y., Lin, W., Fan, Y., Qin, Z., Hu, Y., Zhu, B., Wang, S., Ding, X. and Zhao, G. P.* (2010). Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism. Cell Res 20(10): 1096-1108.
  4. Wang, Q., Zhang, Y., Yang, C., Xiong, H., Lin, Y., Yao, J., Li, H., Xie, L., Zhao, W., Yao, Y., Ning, Z. B., Zeng, R., Xiong, Y., Guan, K. L., Zhao, S. and Zhao, G. P.* (2010). Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science 327(5968): 1004-1007.
  5. Lu, L. D., Sun, Q., Fan, X. Y., Zhong, Y., Yao, Y. F. and Zhao, G. P.* (2010). Mycobacterial MazG is a novel NTP pyrophosphohydrolase involved in oxidative stress response. J Biol Chem 285(36): 28076-28085.
  6. Zheng, H., Lu, L., Wang, B., Pu, S., Zhang, X., Zhu, G., Shi, W., Zhang, L., Wang, H., Wang, S., Zhao, G.* and Zhang, Y. (2008). Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv. PLoS One 3(6): e2375.
  7. Yang, X., Yang, H., Zhou, G. and Zhao, G. P.* (2008). Infectious disease in the genomic era. Annu Rev Genomics Hum Genet 9: 21-48.
  8. Ma, J., Zhang, P., Zhang, Z., Zha, M., Xu, H., Zhao, G.* and Ding, J. (2008). Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans. Biochem J 415(1): 45-56.
  9. Li, M., Wang, B., Zhang, M., Rantalainen, M., Wang, S., Zhou, H., Zhang, Y., Shen, J., Pang, X., Wei, H., Chen, Y., Lu, H., Zuo, J., Su, M., Qiu, Y., Jia, W., Xiao, C., Smith, L. M., Yang, S., Holmes, E., Tang, H., Zhao, G.*, Nicholson, J. K., Li, L. and Zhao, L. (2008). Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A 105(6): 2117-2122.
  10. Qu, X. X., Hao, P., Song, X. J., Jiang, S. M., Liu, Y. X., Wang, P. G., Rao, X., Song, H. D., Wang, S. Y., Zuo, Y., Zheng, A. H., Luo, M., Wang, H. L., Deng, F., Wang, H. Z., Hu, Z. H., Ding, M. X., Zhao, G. P.* and Deng, H. K. (2005). Identification of two critical amino acid residues of the severe acute respiratory syndrome coronavirus spike protein for its variation in zoonotic tropism transition via a double substitution strategy. J Biol Chem 280(33): 29588-29595.
  11. Qian, W., Jia, Y., Ren, S. X., He, Y. Q., Feng, J. X., Lu, L. F., Sun, Q., Ying, G., Tang, D. J., Tang, H., Wu, W., Hao, P., Wang, L., Jiang, B. L., Zeng, S., Gu, W. Y., Lu, G., Rong, L., Tian, Y., Yao, Z., Fu, G., Chen, B., Fang, R., Qiang, B., Chen, Z., Zhao, G. P.*, Tang, J. L. and He, C. (2005). Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris. Genome Res 15(6): 757-767.
  12. Song, H. D., Tu, C. C., Zhang, G. W., Wang, S. Y., Zheng, K., Lei, L. C., Chen, Q. X., Gao, Y. W., Zhou, H. Q., Xiang, H., Zheng, H. J., Chern, S. W., Cheng, F., Pan, C. M., Xuan, H., Chen, S. J., Luo, H. M., Zhou, D. H., Liu, Y. F., He, J. F., Qin, P. Z., Li, L. H., Ren, Y. Q., Liang, W. J., Yu, Y. D., Anderson, L., Wang, M., Xu, R. H., Wu, X. W., Zheng, H. Y., Chen, J. D., Liang, G., Gao, Y., Liao, M., Fang, L., Jiang, L. Y., Li, H., Chen, F., Di, B., He, L. J., Lin, J. Y., Tong, S., Kong, X., Du, L., Hao, P., Tang, H., Bernini, A., Yu, X. J., Spiga, O., Guo, Z. M., Pan, H. Y., He, W. Z., Manuguerra, J. C., Fontanet, A., Danchin, A., Niccolai, N., Li, Y. X., Wu, C. I. and Zhao, G. P.* (2005). Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc Natl Acad Sci U S A 102(7): 2430-2435.
  13. The Chinese SARS molecular epidemiology consortium (2004). Molecular Evolution of the SARS Coronavirus. During the Course of the SARS Epidemic in China. Science. 2004. 303: 1666-1669. (*Correspondent of the whole work)
  14. Ren, S. X., Fu, G., Jiang, X. G., Zeng, R., Miao, Y. G., Xu, H., Zhang, Y. X., Xiong, H., Lu, G., Lu, L. F., Jiang, H. Q., Jia, J., Tu, Y. F., Jiang, J. X., Gu, W. Y., Zhang, Y. Q., Cai, Z., Sheng, H. H., Yin, H. F., Zhang, Y., Zhu, G. F., Wan, M., Huang, H. L., Qian, Z., Wang, S. Y., Ma, W., Yao, Z. J., Shen, Y., Qiang, B. Q., Xia, Q. C., Guo, X. K., Danchin, A., Saint Girons, I., Somerville, R. L., Wen, Y. M., Shi, M. H., Chen, Z., Xu, J. G. and Zhao, G. P.*(2003). Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 422(6934): 888-893.

    *Corresponding author
Protocols by Guo-Ping Zhao
  1. Determination of Rifampicin-resistance Mutation Frequency and Analysis of Mutation Spectra in Mycobacteria