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Jae Jung

Education

Ph.D. in Microbiology, University of California, Davis, 1989

Current position

Distinguished Professor and Chairman, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California

Publications (out of 180 as of 2014)

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  1. Rodgers, M. A., Bowman, J. W., Liang, Q. and Jung, J. U. (2014). Regulation where autophagy intersects the inflammasome. Antioxid Redox Signal 20(3): 495-506.
  2. Liang, Q., Seo, G. J., Choi, Y. J., Kwak, M. J., Ge, J., Rodgers, M. A., Shi, M., Leslie, B. J., Hopfner, K. P., Ha, T., Oh, B. H. and Jung, J. U. (2014). Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses. Cell Host Microbe 15(2): 228-238.
  3. Wong, L. Y., Brulois, K., Toth, Z., Inn, K. S., Lee, S. H., O'Brien, K., Lee, H., Gao, S. J., Cesarman, E., Ensser, A. and Jung, J. U. (2013). The product of Kaposi's sarcoma-associated herpesvirus immediate early gene K4.2 regulates immunoglobulin secretion and calcium homeostasis by interacting with and inhibiting pERP1. J Virol 87(22): 12069-12079.
  4. Toth, Z., Brulois, K., Lee, H. R., Izumiya, Y., Tepper, C., Kung, H. J. and Jung, J. U. (2013). Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. PLoS Pathog 9(12): e1003813.
  5. Liang, Q., Chang, B., Brulois, K. F., Castro, K., Min, C. K., Rodgers, M. A., Shi, M., Ge, J., Feng, P., Oh, B. H. and Jung, J. U. (2013). Kaposi's sarcoma-associated herpesvirus K7 modulates Rubicon-mediated inhibition of autophagosome maturation. J Virol 87(22): 12499-12503.
  6. Amini-Bavil-Olyaee, S., Choi, Y. J., Lee, J. H., Shi, M., Huang, I. C., Farzan, M. and Jung, J. U. (2013). The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry. Cell Host Microbe 13(4): 452-464.
  7. Toth, Z., Brulois, K. F., Wong, L. Y., Lee, H. R., Chung, B. and Jung, J. U. (2012). Negative elongation factor-mediated suppression of RNA polymerase II elongation of Kaposi's sarcoma-associated herpesvirus lytic gene expression. J Virol 86(18): 9696-9707.
  8. Lee, S. H., Toth, Z., Wong, L. Y., Brulois, K., Nguyen, J., Lee, J. Y., Zandi, E. and Jung, J. U. (2012). Novel Phosphorylations of IKKgamma/NEMO. MBio 3(6): e00411-00412.
  9. Kim, H. J., Zhong, Q., Sheng, Z. H., Yoshimori, T., Liang, C. and Jung, J. U. (2012). Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J Cell Sci 125(Pt 20): 4740-4750.
  10. Brulois, K. F., Chang, H., Lee, A. S., Ensser, A., Wong, L. Y., Toth, Z., Lee, S. H., Lee, H. R., Myoung, J., Ganem, D., Oh, T. K., Kim, J. F., Gao, S. J. and Jung, J. U. (2012). Construction and manipulation of a new Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome clone. J Virol 86(18): 9708-9720.
  11. Jeong, J. H., Bhatia, A., Toth, Z., Oh, S., Inn, K. S., Liao, C. P., Roy-Burman, P., Melamed, J., Coetzee, G. A. and Jung, J. U. (2011). TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth. PLoS One 6(1): e16205.
  12. Inn, K. S., Lee, S. H., Rathbun, J. Y., Wong, L. Y., Toth, Z., Machida, K., Ou, J. H. and Jung, J. U. (2011). Inhibition of RIG-I-mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64. J Virol 85(20): 10899-10904.
  13. Inn, K. S., Gack, M. U., Tokunaga, F., Shi, M., Wong, L. Y., Iwai, K. and Jung, J. U. (2011). Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction. Mol Cell 41(3): 354-365.
  14. Toth, Z., Maglinte, D. T., Lee, S. H., Lee, H. R., Wong, L. Y., Brulois, K. F., Lee, S., Buckley, J. D., Laird, P. W., Marquez, V. E. and Jung, J. U. (2010). Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog 6(7): e1001013.
  15. Gack, M. U., Nistal-Villan, E., Inn, K. S., Garcia-Sastre, A. and Jung, J. U. (2010). Phosphorylation-mediated negative regulation of RIG-I antiviral activity. J Virol 84(7): 3220-3229.
  16. Lee, J. S., Li, Q., Lee, J. Y., Lee, S. H., Jeong, J. H., Lee, H. R., Chang, H., Zhou, F. C., Gao, S. J., Liang, C. and Jung, J. U. (2009). FLIP-mediated autophagy regulation in cell death control. Nat Cell Biol 11(11): 1355-1362.
  17. Gack, M. U., Albrecht, R. A., Urano, T., Inn, K. S., Huang, I. C., Carnero, E., Farzan, M., Inoue, S., Jung, J. U. and Garcia-Sastre, A. (2009). Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. Cell Host Microbe 5(5): 439-449.
  18. E, X., Hwang, S., Oh, S., Lee, J. S., Jeong, J. H., Gwack, Y., Kowalik, T. F., Sun, R., Jung, J. U. and Liang, C. (2009). Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68. PLoS Pathog 5(10): e1000609.
  19. Chang, H., Wachtman, L. M., Pearson, C. B., Lee, J. S., Lee, H. R., Lee, S. H., Vieira, J., Mansfield, K. G. and Jung, J. U. (2009). Non-human primate model of Kaposi's sarcoma-associated herpesvirus infection. PLoS Pathog 5(10): e1000606.
  20. Shin, Y. C., Joo, C. H., Gack, M. U., Lee, H. R. and Jung, J. U. (2008). Kaposi's sarcoma-associated herpesvirus viral IFN regulatory factor 3 stabilizes hypoxia-inducible factor-1 alpha to induce vascular endothelial growth factor expression. Cancer Res 68(6): 1751-1759.
  21. Liang, C., Lee, J. S., Inn, K. S., Gack, M. U., Li, Q., Roberts, E. A., Vergne, I., Deretic, V., Feng, P., Akazawa, C. and Jung, J. U. (2008). Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol 10(7): 776-787.
  22. Gack, M. U., Kirchhofer, A., Shin, Y. C., Inn, K. S., Liang, C., Cui, S., Myong, S., Ha, T., Hopfner, K. P. and Jung, J. U. (2008). Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. Proc Natl Acad Sci U S A 105(43): 16743-16748.
  23. Gack, M. U., Shin, Y. C., Joo, C. H., Urano, T., Liang, C., Sun, L., Takeuchi, O., Akira, S., Chen, Z., Inoue, S. and Jung, J. U. (2007). TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446(7138): 916-920.
  24. Shin, Y. C., Nakamura, H., Liang, X., Feng, P., Chang, H., Kowalik, T. F. and Jung, J. U. (2006). Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1. J Virol 80(5): 2257-2266.
Protocols by Jae Jung
  1. Pulse Chase of Suspension Cells