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Lai-Yee Wong


Ph.D., Department of Microbiology, New York University School of Medicine, New York, NY

Current position

Research Associate, Department of Molecular Microbiology & Immunology, University of Southern California, Los Angeles, CA


  1. Brulois, K., Toth, Z., Wong, L. Y., Feng, P., Gao, S. J., Ensser, A. and Jung, J. U. (2014). KSHV K3 and K5 ubiquitin E3 ligases have stage-specific immune evasion roles during lytic replication. J Virol. (Epub ahead of print)
  2. Wong, L. Y., Brulois, K., Toth, Z., Inn, K. S., Lee, S. H., O'Brien, K., Lee, H., Gao, S. J., Cesarman, E., Ensser, A. and Jung, J. U. (2013). The product of Kaposi's sarcoma-associated herpesvirus immediate early gene K4.2 regulates immunoglobulin secretion and calcium homeostasis by interacting with and inhibiting pERP1. J Virol 87(22): 12069-12079.
  3. Wong, L. Y., Toth, Z., Brulois, K. Inn, K. S., Lee, S. H. and Jung, J. U. (2013). Pathogen mimicry of host cell signaling: how γ-2 herpesviruses modulate primate immune pathways. In: Primates, Pathogens and Evolution. Springer, 221-251.
  4. Wang, Y., Lu, X., Zhu, L., Shen, Y., Chengedza, S., Feng, H., Wang, L., Jung, J. U., Gutkind, J. S. and Feng, P. (2013). IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis. Proc Natl Acad Sci U S A 110(27): 11139-11144.
  5. Lee, S. H., Toth, Z., Wong, L. Y., Brulois, K., Nguyen, J., Lee, J. Y., Zandi, E. and Jung, J. U. (2012). Novel Phosphorylations of IKKgamma/NEMO. MBio 3(6): e00411-00412.
  6. Toth, Z., Brulois, K. F., Wong, L. Y., Lee, H. R., Chung, B. and Jung, J. U. (2012). Negative elongation factor-mediated suppression of RNA polymerase II elongation of Kaposi's sarcoma-associated herpesvirus lytic gene expression. J Virol 86(18): 9696-9707.
  7. Brulois, K. F., Chang, H., Lee, A. S., Ensser, A., Wong, L. Y., Toth, Z., Lee, S. H., Lee, H. R., Myoung, J., Ganem, D., Oh, T. K., Kim, J. F., Gao, S. J. and Jung, J. U. (2012). Construction and manipulation of a new Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome clone. J Virol 86(18): 9708-9720.
  8. Lee, H. R., Brulois, K., Wong, L. and Jung, J. U. (2012). Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies. Front Microbiol 3: 44.
  9. Inn, K. S., Lee, S. H., Rathbun, J. Y., Wong, L. Y., Toth, Z., Machida, K., Ou, J. H. and Jung, J. U. (2011). Inhibition of RIG-I-mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64. J Virol 85(20): 10899-10904.
  10. Inn, K. S., Gack, M. U., Tokunaga, F., Shi, M., Wong, L. Y., Iwai, K. and Jung, J. U. (2011). Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction. Mol Cell 41(3): 354-365.
  11. Toth, Z., Maglinte, D. T., Lee, S. H., Lee, H. R., Wong, L. Y., Brulois, K. F., Lee, S., Buckley, J. D., Laird, P. W., Marquez, V. E. and Jung, J. U. (2010). Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog 6(7): e1001013.
  12. Matsumura, S., Persson, L. M., Wong, L. and Wilson, A. C. (2010). The latency-associated nuclear antigen interacts with MeCP2 and nucleosomes through separate domains. J Virol 84(5): 2318-2330.
  13. Wong, L. Y., Recht, J. and Laurent, B. C. (2006). Chromatin remodeling and repair of DNA double-strand breaks. J Mol Histol 37(5-7): 261-269.
  14. Wong, L. Y., and Wilson, A. C. (2005). KSHV Latency-Associated Nuclear Antigen induces a strong bend on binding to terminal repeat DNA. Journal of Virology 79: 13829-13836.
  15. Wong, L.-Y., Matchett, G. A. and Wilson, A. C. (2004). Transcriptional activation by the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen is facilitated by an N-terminal chromatin-binding motif. Journal of virology 78(18): 10074-10085.
  16. Schwam, D. R., Luciano, R. L., Mahajan, S. S., Wong, L. and Wilson, A. C. (2000). Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies. Journal of virology 74(18): 8532-8540.
Protocols by Lai-Yee Wong
  1. Pulse Chase of Suspension Cells