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Marc E. Rothenberg

Education

M.D., Ph.D., Harvard Medical School, Cambridge, Massachusetts, USA

Current position

Endowed Chair, Allergy and Immunology, Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio, USA (since 2001)
Director, Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA (since 2001)
Professor of Pediatrics (tenured), Department of Pediatrics, University of Cincinnati College of Medicine, Ohio, USA (since 2002)
Director, Cincinnati Center for Eosinophilic Disorders, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA (since 2005)
Visiting Full Professor, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel (since 2010)

Publications

Original peer reviewed references (since 2009)

  1. Sherrill, J. D., Kiran, K. C., Blanchard, C., Stucke, E. M., Kemme, K. A., Collins, M. H., Abonia, J. P., Putnam, P. E., Mukkada, V. A., Kaul, A., Kocoshis, S. A., Kushner, J. P., Plassard, A. J., Karns, R. A., Dexheimer, P. J., Aronow, B. J. and Rothenberg, M. E. (2014). Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing. Genes Immun. (Epub ahead of print)
  2. Wen, T., Mingler, M. K., Wahl, B., Khorki, M. E., Pabst, O., Zimmermann, N. and Rothenberg, M. E. (2014). Carbonic Anhydrase IV Is Expressed on IL-5-Activated Murine Eosinophils. J Immunol 192(12): 5481-5489.
  3. Jung, Y. J and Rothenberg, M. E. Roles and regulation of gastrointestinal eosinophils in immunity and disease. J Immunol (In press)
  4. Butz, B. K., Wen, T., Gleich, G. J., Furuta, G. T., Spergel, J., King, E., Kramer, R. E., Collins, M. H., Stucke, E., Mangeot, C., Jackson, W. D., O'Gorman, M., Abonia, J. P., Pentiuk, S., Putnam, P. E. and Rothenberg, M. E. (2014). Efficacy, Dose Reduction, and Resistance to High-Dose Fluticasone in Patients With Eosinophilic Esophagitis. Gastroenterology. (Epub ahead of print)
  5. Sherrill, J. D. and Rothenberg, M. E. (2014). Genetic and epigenetic underpinnings of eosinophilic esophagitis. Gastroenterol Clin North Am 43(2): 269-280.
  6. Minar, P., Haberman, Y., Jurickova, I., Wen, T., Rothenberg, M. E., Kim, M. O., Saeed, S. A., Baldassano, R. N., Stephens, M., Markowitz, J., Rosh, J., Crandall, W. V., Heyman, M. B., Mack, D. R., Griffiths, A. M., Baker, S. S., Hyams, J. S., Kugathasan, S. and Denson, L. A. (2014). Utility of Neutrophil Fcgamma Receptor I (CD64) Index as a Biomarker for Mucosal Inflammation in Pediatric Crohn's Disease. Inflamm Bowel Dis 20(6): 1037-1048.
  7. Davis, B. P. and Rothenberg, M. E. (2014). Eosinophils and cancer. Cancer Immunol Res 2(1): 1-8.
  8. Azouz, N. P., Zur, N., Efergan, A., Ohbayashi, N., Fukuda, M., Amihai, D., Hammel, I., Rothenberg, M. E. and Sagi-Eisenberg, R. (2014). Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis. The Journal of Immunology 192(9): 4043-4053.
  9. Lyons, J. J., Sun, G., Stone, K. D., Nelson, C., Wisch, L., O'Brien, M., Jones, N., Lindsley, A., Komarow, H. D., Bai, Y., Scott, L. M., Cantave, D., Maric, I., Abonia, J. P., Rothenberg, M. E., Schwartz, L. B., Milner, J. D. and Wilson, T. M. (2014). Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities. J Allergy Clin Immunol 133(5): 1471-1474.
  10. Lim, E. and Rothenberg, M. E. (2014). Demethylation of the human eotaxin-3 gene promoter leads to the elevated expression of eotaxin-3. J Immunol 192(1): 466-474.
  11. Krishnamurthy, P., Sherrill, J. D., Parashette, K., Goenka, S., Rothenberg, M. E., Gupta, S. and Kaplan, M. H. (2014). Correlation of increased PARP14 and CCL26 expression in biopsies from children with eosinophilic esophagitis. J Allergy Clin Immunol 133(2): 577-580.
  12. Sherrill, J. D., Kc, K., Wu, D., Djukic, Z., Caldwell, J. M., Stucke, E. M., Kemme, K. A., Costello, M. S., Mingler, M. K., Blanchard, C., Collins, M. H., Abonia, J. P., Putnam, P. E., Dellon, E. S., Orlando, R. C., Hogan, S. P. and Rothenberg, M. E. (2014). Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis. Mucosal Immunol 7(3): 718-729.
  13. Ben Baruch-Morgenstern, N., Shik, D., Moshkovits, I., Itan, M., Karo-Atar, D., Bouffi, C., Fulkerson, P. C., Rashkovan, D., Jung, S., Rothenberg, M. E. and Munitz, A. (2014). Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development. Nat Immunol 15(1): 36-44.
  14. Greenhawt, M., Aceves, S. S., Spergel, J. M. and Rothenberg, M. E. (2013). The Management of Eosinophilic Esophagitis. The Journal of Allergy and Clinical Immunology: In Practice 1(4): 332-340.
  15. Henderson, C. J., Ngeow, J., Collins, M. H., Martin, L. J., Putnam, P. E., Abonia, J. P., Marsolo, K., Eng, C. and Rothenberg, M. E. (2013). Increased prevalence of eosinophilic gastrointestinal disorders (EGID) in pediatric PTEN hamartoma tumor syndromes (PHTS). Journal of pediatric gastroenterology and nutrition 58:553-60.
  16. Davis, B. P. and Rothenberg, M. E. (2013). Antigen presentation by eosinophils in eosinophilic esophagitis? J Pediatr Gastroenterol Nutr 56(3): 242.
  17. Henderson, C. J., Collins, M. H., Abonia, J. P., Putnam, P. E. and Rothenberg, M. E. (2013). Reply: To PMID 22541246. J Allergy Clin Immunol 131(1): 243-244.
  18. Roufosse, F. E., Kahn, J. E., Gleich, G. J., Schwartz, L. B., Singh, A. D., Rosenwasser, L. J., Denburg, J. A., Ring, J., Rothenberg, M. E., Sheikh, J., Haig, A. E., Mallett, S. A., Templeton, D. N., Ortega, H. G. and Klion, A. D. (2013). Long-term safety of mepolizumab for the treatment of hypereosinophilic syndromes. J Allergy Clin Immunol 131(2): 461-467 e461-465.
  19. Sheikh, S. Z. and Burks, A. W. (2013). Behavioral Feeding Problems and Parenting Stress in Eosinophilic Gastrointestinal Disorders in Children. Pediatrics 132(Supplement 1): S24-S24.
  20. Assa'ad, A. H. and Rothenberg, M. E. (2013). Eosinophilic asthma: insights into the effects of reducing IL-5 receptor-positive cell levels. J Allergy Clin Immunol 132(5): 1097-1098.
  21. Bouffi, C., Rochman, M., Zust, C. B., Stucke, E. M., Kartashov, A., Fulkerson, P. C., Barski, A. and Rothenberg, M. E. (2013). IL-33 markedly activates murine eosinophils by an NF-kappaB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop. J Immunol 191(8): 4317-4325.
  22. Wen, T., Stucke, E. M., Grotjan, T. M., Kemme, K. A., Abonia, J. P., Putnam, P. E., Franciosi, J. P., Garza, J. M., Kaul, A., King, E. C., Collins, M. H., Kushner, J. P. and Rothenberg, M. E. (2013). Molecular diagnosis of eosinophilic esophagitis by gene expression profiling. Gastroenterology 145(6): 1289-1299.
  23. Ding, L., Abebe, T., Beyene, J., Wilke, R. A., Goldberg, A., Woo, J. G., Martin, L. J., Rothenberg, M. E., Rao, M., Hershey, G. K., Chakraborty, R. and Mersha, T. B. (2013). Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations. Hum Genomics 7: 16.
  24. Lu, T. X. and Rothenberg, M. E. (2013). Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases. J Allergy Clin Immunol 132(1): 3-13; quiz 14.
  25. Wang, Y. H., Hogan, S. P., Fulkerson, P. C., Abonia, J. P. and Rothenberg, M. E. (2013). Expanding the paradigm of eosinophilic esophagitis: mast cells and IL-9. J Allergy Clin Immunol 131(6): 1583-1585.
  26. Abonia, J. P., Wen, T., Stucke, E. M., Grotjan, T., Griffith, M. S., Kemme, K. A., Collins, M. H., Putnam, P. E., Franciosi, J. P., von Tiehl, K. F., Tinkle, B. T., Marsolo, K. A., Martin, L. J., Ware, S. M. and Rothenberg, M. E. (2013). High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders. J Allergy Clin Immunol 132(2): 378-386.
  27. Davis, B. P. and Rothenberg, M. E. (2013). Emerging concepts of dietary therapy for pediatric and adult eosinophilic esophagitis. Expert Rev Clin Immunol 9(4): 285-287.
  28. Wen, T., Besse, J. A., Mingler, M. K., Fulkerson, P. C. and Rothenberg, M. E. (2013). Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo. Proc Natl Acad Sci U S A 110(15): 6067-6072.
  29. Lu, T. X., Lim, E. J., Itskovich, S., Besse, J. A., Plassard, A. J., Mingler, M. K., Rothenberg, J. A., Fulkerson, P. C., Aronow, B. J. and Rothenberg, M. E. (2013). Targeted ablation of miR-21 decreases murine eosinophil progenitor cell growth. PLoS One 8(3): e59397.
  30. Franciosi, J. P., Hommel, K. A., Bendo, C. B., King, E. C., Collins, M. H., Eby, M. D., Marsolo, K., Abonia, J. P., von Tiehl, K. F., Putnam, P. E., Greenler, A. J., Greenberg, A. B., Bryson, R. A., Davis, C. M., Olive, A. P., Gupta, S. K., Erwin, E. A., Klinnert, M. D., Spergel, J. M., Denham, J. M., Furuta, G. T., Rothenberg, M. E. and Varni, J. W. (2013). PedsQL eosinophilic esophagitis module: feasibility, reliability, and validity. J Pediatr Gastroenterol Nutr 57(1): 57-66.
  31. Bochner, B. S., Rothenberg, M. E., Boyce, J. A. and Finkelman, F. (2013). Advances in mechanisms of allergy and clinical immunology in 2012. J Allergy Clin Immunol 131(3): 661-667.
  32. Collison, A., Hatchwell, L., Verrills, N., Wark, P. A., de Siqueira, A. P., Tooze, M., Carpenter, H., Don, A. S., Morris, J. C., Zimmermann, N., Bartlett, N. W., Rothenberg, M. E., Johnston, S. L., Foster, P. S. and Mattes, J. (2013). The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity. Nat Med 19(2): 232-237.
  33. Fulkerson, P. C. and Rothenberg, M. E. (2013). Targeting eosinophils in allergy, inflammation and beyond. Nat Rev Drug Discov 12(2): 117-129.
  34. Lu, T. X., Lim, E. J., Besse, J. A., Itskovich, S., Plassard, A. J., Fulkerson, P. C., Aronow, B. J. and Rothenberg, M. E. (2013). MiR-223 deficiency increases eosinophil progenitor proliferation. J Immunol 190(4): 1576-1582.
  35. Valent, P., Klion, A. D., Rosenwasser, L. J., Arock, M., Bochner, B. S., Butterfield, J. H., Gotlib, J., Haferlach, T., Hellmann, A., Horny, H. P., Leiferman, K. M., Metzgeroth, G., Matsumoto, K., Reiter, A., Roufosse, F., Rothenberg, M. E., Simon, H. U., Sotlar, K., Vandenberghe, P., Weller, P. F. and Gleich, G. J. (2012). ICON: Eosinophil Disorders. World Allergy Organ J 5(12): 174-181.
  36. Winer, K. K., Rothenberg, M. E., Guimond, J., Handwerger, S., Boxer, L. A., Grave, G., Devaskar, S. U. and Castle, V. P. (2012). The Child Health Research Centers: twenty-one years of promoting the development of pediatrician scientists from 1990-2011. J Pediatr 161(6): 975-976.
  37. Franciosi, J. P., Hommel, K. A., Greenberg, A. B., DeBrosse, C. W., Greenler, A. J., Abonia, J. P., Rothenberg, M. E. and Varni, J. W. (2012). Development of the Pediatric Quality of Life Inventory Eosinophilic Esophagitis module items: qualitative methods. BMC Gastroenterol 12: 135.
  38. Rothenberg, M. E., Aceves, S., Bonis, P. A., Collins, M. H., Gonsalves, N., Gupta, S. K., Hirano, I., Liacouras, C. A., Putnam, P. E., Spergel, J. M., Straumann, A., Wershil, B. K. and Furuta, G. T. (2012). Working with the US Food and Drug Administration: progress and timelines in understanding and treating patients with eosinophilic esophagitis. J Allergy Clin Immunol 130(3): 617-619.
  39. Bochner, B. S., Book, W., Busse, W. W., Butterfield, J., Furuta, G. T., Gleich, G. J., Klion, A. D., Lee, J. J., Leiferman, K. M., Minnicozzi, M., Moqbel, R., Rothenberg, M. E., Schwartz, L. B., Simon, H. U., Wechsler, M. E. and Weller, P. F. (2012). Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD). J Allergy Clin Immunol 130(3): 587-596.
  40. Wechsler, M. E., Fulkerson, P. C., Bochner, B. S., Gauvreau, G. M., Gleich, G. J., Henkel, T., Kolbeck, R., Mathur, S. K., Ortega, H., Patel, J., Prussin, C., Renzi, P., Rothenberg, M. E., Roufosse, F., Simon, D., Simon, H. U., Wardlaw, A., Weller, P. F. and Klion, A. D. (2012). Novel targeted therapies for eosinophilic disorders. J Allergy Clin Immunol 130(3): 563-571.
  41. Butsch Kovacic, M., Biagini Myers, J. M., Lindsey, M., Patterson, T., Sauter, S., Ericksen, M. B., Ryan, P., Assa'ad, A., Lierl, M., Fischer, T., Kercsmar, C., McDowell, K., Lucky, A. W., Sheth, A. P., Hershey, A. D., Ruddy, R. M., Rothenberg, M. E. and Khurana Hershey, G. K. (2012). The Greater Cincinnati Pediatric Clinic Repository: A Novel Framework for Childhood Asthma and Allergy Research. Pediatr Allergy Immunol Pulmonol 25(2): 104-113.
  42. Henderson, C. J., Abonia, J. P., King, E. C., Putnam, P. E., Collins, M. H., Franciosi, J. P. and Rothenberg, M. E. (2012). Comparative dietary therapy effectiveness in remission of pediatric eosinophilic esophagitis. J Allergy Clin Immunol 129(6): 1570-1578.
  43. Lu, T., Lim, E., Wen, T., Plassard, A., Hogan, S., Martin, L., Aronow, B. and Rothenberg, M. (2012). MiR-375 is downregulated in epithelial cells after IL-13 stimulation and regulates an IL-13-induced epithelial transcriptome. Mucosal immunology 5(4): 388-396.
  44. Hommel, K. A., Franciosi, J. P., Gray, W. N., Hente, E. A., Ahrens, A. and Rothenberg, M. E. (2012). Behavioral functioning and treatment adherence in pediatric eosinophilic gastrointestinal disorders. Pediatric Allergy and Immunology 23(5): 494-499.
  45. Lu, T. X., Sherrill, J. D., Wen, T., Plassard, A. J., Besse, J. A., Abonia, J. P., Franciosi, J. P., Putnam, P. E., Eby, M., Martin, L. J., Aronow, B. J. and Rothenberg, M. E. (2012). MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers. J Allergy Clin Immunol 129(4): 1064-1075 e1069.
  46. Boyce, J. A., Bochner, B., Finkelman, F. D. and Rothenberg, M. E. (2012). Advances in mechanisms of asthma, allergy, and immunology in 2011. J Allergy Clin Immunol 129(2): 335-341.
  47. Munitz, A., Cole, E. T., Karo-Atar, D., Finkelman, F. D. and Rothenberg, M. E. (2012). Resistin-like molecule-alpha regulates IL-13-induced chemokine production but not allergen-induced airway responses. Am J Respir Cell Mol Biol 46(5): 703-713.
  48. Spergel, J. M., Rothenberg, M. E., Collins, M. H., Furuta, G. T., Markowitz, J. E., Fuchs, G., 3rd, O'Gorman, M. A., Abonia, J. P., Young, J., Henkel, T., Wilkins, H. J. and Liacouras, C. A. (2012). Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 129(2): 456-463, 463 e451-453.
  49. Wen, T., Mingler, M. K., Blanchard, C., Wahl, B., Pabst, O. and Rothenberg, M. E. (2012). The pan-B cell marker CD22 is expressed on gastrointestinal eosinophils and negatively regulates tissue eosinophilia. J Immunol 188(3): 1075-1082.
  50. Hommel, K. A., Franciosi, J. P., Hente, E. A., Ahrens, A. and Rothenberg, M. E. (2012). Treatment adherence in pediatric eosinophilic gastrointestinal disorders. J Pediatr Psychol 37(5): 533-542.
  51. Abonia, J. P. and Rothenberg, M. E. (2012). Eosinophilic esophagitis: rapidly advancing insights. Annu Rev Med 63: 421-434.
  52. Munitz, A., Cole, E. T., Karo-Atar, D., Finkelman, F. D. and Rothenberg, M. E. (2012). Resistin-Like Molecule–α Regulates IL-13–Induced Chemokine Production but Not Allergen-Induced Airway Responses. American journal of respiratory cell and molecular biology 46(5): 703-713.
  53. Franciosi, J., Hommel, K., DeBrosse, C., Greenberg, A., Greenler, A., Abonia, J., Rothenberg, M. and Varni, J. (2012). Quality of life in paediatric eosinophilic oesophagitis: what is important to patients? Child: care, health and development 38(4): 477-483.
  54. Franciosi, J. P., Hommel, K. A., DeBrosse, C. W., Greenberg, A. B., Greenler, A. J., Abonia, J. P., Rothenberg, M. E. and Varni, J. W. (2011). Development of a validated patient-reported symptom metric for pediatric eosinophilic esophagitis: qualitative methods. BMC Gastroenterol 11: 126.
  55. Rothenberg, M. E., Wen, T., Shik, D., Cole, E. T., Mingler, M. M. and Munitz, A. (2011). IL-13 receptor alpha1 differentially regulates aeroallergen-induced lung responses. J Immunol 187(9): 4873-4880.
  56. Lu, T. X., Hartner, J., Lim, E. J., Fabry, V., Mingler, M. K., Cole, E. T., Orkin, S. H., Aronow, B. J. and Rothenberg, M. E. (2011). MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. J Immunol 187(6): 3362-3373.
  57. DeBrosse, C. W., Franciosi, J. P., King, E. C., Butz, B. K., Greenberg, A. B., Collins, M. H., Abonia, J. P., Assa'ad, A., Putnam, P. E. and Rothenberg, M. E. (2011). Long-term outcomes in pediatric-onset esophageal eosinophilia. J Allergy Clin Immunol 128(1): 132-138.
  58. Lacy, P., Willetts, L., Kim, J. D., Lo, A. N., Lam, B., Maclean, E. I., Moqbel, R., Rothenberg, M. E. and Zimmermann, N. (2011). Agonist activation of f-actin-mediated eosinophil shape change and mediator release is dependent on Rac2. Int Arch Allergy Immunol 156(2): 137-147.
  59. Sherrill, J. D. and Rothenberg, M. E. (2011). Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies. J Allergy Clin Immunol 128(1): 23-32; quiz 33-24.
  60. Waddell, A., Ahrens, R., Steinbrecher, K., Donovan, B., Rothenberg, M. E., Munitz, A. and Hogan, S. P. (2011). Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11. J Immunol 186(10): 5993-6003.
  61. Liacouras, C. A., Furuta, G. T., Hirano, I., Atkins, D., Attwood, S. E., Bonis, P. A., Burks, A. W., Chehade, M., Collins, M. H., Dellon, E. S., Dohil, R., Falk, G. W., Gonsalves, N., Gupta, S. K., Katzka, D. A., Lucendo, A. J., Markowitz, J. E., Noel, R. J., Odze, R. D., Putnam, P. E., Richter, J. E., Romero, Y., Ruchelli, E., Sampson, H. A., Schoepfer, A., Shaheen, N. J., Sicherer, S. H., Spechler, S., Spergel, J. M., Straumann, A., Wershil, B. K., Rothenberg, M. E. and Aceves, S. S. (2011). Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol 128(1): 3-20 e26; quiz 21-22.
  62. Baye, T. M., Butsch Kovacic, M., Biagini Myers, J. M., Martin, L. J., Lindsey, M., Patterson, T. L., He, H., Ericksen, M. B., Gupta, J., Tsoras, A. M., Lindsley, A., Rothenberg, M. E., Wills-Karp, M., Eissa, N. T., Borish, L. and Khurana Hershey, G. K. (2011). Differences in candidate gene association between European ancestry and African American asthmatic children. PLoS One 6(2): e16522.
  63. Broide, D. H., Finkelman, F., Bochner, B. S. and Rothenberg, M. E. (2011). Advances in mechanisms of asthma, allergy, and immunology in 2010. J Allergy Clin Immunol 127(3): 689-695.
  64. Lim, E. J., Lu, T. X., Blanchard, C. and Rothenberg, M. E. (2011). Epigenetic regulation of the IL-13-induced human eotaxin-3 gene by CREB-binding protein-mediated histone 3 acetylation. J Biol Chem 286(15): 13193-13204.
  65. Wu, D., Ahrens, R., Osterfeld, H., Noah, T. K., Groschwitz, K., Foster, P. S., Steinbrecher, K. A., Rothenberg, M. E., Shroyer, N. F., Matthaei, K. I., Finkelman, F. D. and Hogan, S. P. (2011). Interleukin-13 (IL-13)/IL-13 receptor alpha1 (IL-13Ralpha1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-dependent Cl- secretion. J Biol Chem 286(15): 13357-13369.
  66. Blanchard, C., Stucke, E. M., Rodriguez-Jimenez, B., Burwinkel, K., Collins, M. H., Ahrens, A., Alexander, E. S., Butz, B. K., Jameson, S. C., Kaul, A., Franciosi, J. P., Kushner, J. P., Putnam, P. E., Abonia, J. P. and Rothenberg, M. E. (2011). A striking local esophageal cytokine expression profile in eosinophilic esophagitis. J Allergy Clin Immunol 127(1): 208-217, 217 e201-207.
  67. Zhu, H., Perkins, C., Mingler, M. K., Finkelman, F. D. and Rothenberg, M. E. (2011). The role of neuropeptide S and neuropeptide S receptor 1 in regulation of respiratory function in mice. Peptides 32(4): 818-825.
  68. Miles, M. V., Putnam, P. E., Miles, L., Tang, P. H., DeGrauw, A. J., Wong, B. L., Horn, P. S., Foote, H. L. and Rothenberg, M. E. (2011). Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion 11(1): 127-135.
  69. Cortina, S., McGraw, K., Dealarcon, A., Ahrens, A., Rothenberg, M. E. and Drotar, D. (2010). Psychological Functioning of Children and Adolescents With Eosinophil-Associated Gastrointestinal Disorders. Child Health Care 39(4): 266-278.
  70. Abonia, J. P., Franciosi, J. P. and Rothenberg, M. E. (2010). TGFβ1: Mediator of a feedback loop in eosinophilic esophagitis… or should we really say mastocytic esophagitis? The Journal of allergy and clinical immunology 126(6): 1205.
  71. Sivaprasad, U., Warrier, M. R., Gibson, A. M., Chen, W., Tabata, Y., Bass, S. A., Rothenberg, M. E. and Hershey, G. K. K. (2010). IL-13Rα2 has a protective role in a mouse model of cutaneous inflammation. The Journal of Immunology 185(11): 6802-6808.
  72. Rothenberg, M. E. (2010). Innate sensing of nickel. Nat Immunol 11(9): 781-782.
  73. Simon, H. U., Rothenberg, M. E., Bochner, B. S., Weller, P. F., Wardlaw, A. J., Wechsler, M. E., Rosenwasser, L. J., Roufosse, F., Gleich, G. J. and Klion, A. D. (2010). Refining the definition of hypereosinophilic syndrome. J Allergy Clin Immunol 126(1): 45-49.
  74. Sherrill, J. D., Gao, P. S., Stucke, E. M., Blanchard, C., Collins, M. H., Putnam, P. E., Franciosi, J. P., Kushner, J. P., Abonia, J. P., Assa'ad, A. H., Kovacic, M. B., Biagini Myers, J. M., Bochner, B. S., He, H., Hershey, G. K., Martin, L. J. and Rothenberg, M. E. (2010). Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol 126(1): 160-165 e163.
  75. DeBrosse, C. W., Collins, M. H., Buckmeier Butz, B. K., Allen, C. L., King, E. C., Assa'ad, A. H., Abonia, J. P., Putnam, P. E., Rothenberg, M. E. and Franciosi, J. P. (2010). Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999. J Allergy Clin Immunol 126(1): 112-119.
  76. Niese, K. A., Chiaramonte, M. G., Ellies, L. G., Rothenberg, M. E. and Zimmermann, N. (2010). The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis. Respir Res 11: 87.
  77. Zuo, L., Fulkerson, P. C., Finkelman, F. D., Mingler, M., Fischetti, C. A., Blanchard, C. and Rothenberg, M. E. (2010). IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway. J Immunol 185(1): 660-669.
  78. Abonia, J. P., Blanchard, C., Butz, B. B., Rainey, H. F., Collins, M. H., Stringer, K., Putnam, P. E. and Rothenberg, M. E. (2010). Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol 126(1): 140-149.
  79. Rosenwasser, L. J. and Rothenberg, M. E. (2010). IL-5 pathway inhibition in the treatment of asthma and Churg-Strauss syndrome. J Allergy Clin Immunol 125(6): 1245-1246.
  80. Herbert, D. R., Orekov, T., Roloson, A., Ilies, M., Perkins, C., O'Brien, W., Cederbaum, S., Christianson, D. W., Zimmermann, N., Rothenberg, M. E. and Finkelman, F. D. (2010). Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. J Immunol 184(11): 6438-6446.
  81. Rayapudi, M., Mavi, P., Zhu, X., Pandey, A. K., Abonia, J. P., Rothenberg, M. E. and Mishra, A. (2010). Indoor insect allergens are potent inducers of experimental eosinophilic esophagitis in mice. J Leukoc Biol 88(2): 337-346.
  82. Munitz, A., Cole, E. T., Beichler, A., Groschwitz, K., Ahrens, R., Steinbrecher, K., Willson, T., Han, X., Denson, L., Rothenberg, M. E. and Hogan, S. P. (2010). Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis. Gastroenterology 139(2): 530-541.
  83. Simon, D., Wardlaw, A. and Rothenberg, M. E. (2010). Organ-specific eosinophilic disorders of the skin, lung, and gastrointestinal tract. J Allergy Clin Immunol 126(1): 3-13; quiz 14-15.
  84. Simon, D., Wardlaw, A. and Rothenberg, M. E. (2010). Organ-specific eosinophilic disorders of the skin, lung, and gastrointestinal tract. J Allergy Clin Immunol 126(1): 3-13; quiz 14-15. Zhu, X., Wang, M., Mavi, P., Rayapudi, M., Pandey, A. K., Kaul, A., Putnam, P. E., Rothenberg, M. E. and Mishra, A. (2010). Interleukin-15 expression is increased in human eosinophilic esophagitis and mediates pathogenesis in mice. Gastroenterology 139(1): 182-193. e187.
  85. Caldwell, J. M., Blanchard, C., Collins, M. H., Putnam, P. E., Kaul, A., Aceves, S. S., Bouska, C. A. and Rothenberg, M. E. (2010). Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. J Allergy Clin Immunol 125(4): 879-888 e878.
  86. Rothenberg, M. E., Spergel, J. M., Sherrill, J. D., Annaiah, K., Martin, L. J., Cianferoni, A., Gober, L., Kim, C., Glessner, J., Frackelton, E., Thomas, K., Blanchard, C., Liacouras, C., Verma, R., Aceves, S., Collins, M. H., Brown-Whitehorn, T., Putnam, P. E., Franciosi, J. P., Chiavacci, R. M., Grant, S. F., Abonia, J. P., Sleiman, P. M. and Hakonarson, H. (2010). Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet 42(4): 289-291.
  87. Blanchard, C., Stucke, E. M., Burwinkel, K., Caldwell, J. M., Collins, M. H., Ahrens, A., Buckmeier, B. K., Jameson, S. C., Greenberg, A. and Kaul, A. (2010). Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. The Journal of Immunology 184(7): 4033-4041.
  88. Zhu, H., Mingler, M. K., McBride, M. L., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Williams, M. T., Vorhees, C. V. and Rothenberg, M. E. (2010). Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1. Psychoneuroendocrinology 35(8): 1119-1132.
  89. Finkelman, F. D., Boyce, J. A., Vercelli, D. and Rothenberg, M. E. (2010). Key advances in mechanisms of asthma, allergy, and immunology in 2009. J Allergy Clin Immunol 125(2): 312-318.
  90. Finkelman, F. D., Hogan, S. P., Hershey, G. K., Rothenberg, M. E. and Wills-Karp, M. (2010). Importance of cytokines in murine allergic airway disease and human asthma. J Immunol 184(4): 1663-1674.
  91. Vicario, M., Blanchard, C., Stringer, K. F., Collins, M. H., Mingler, M. K., Ahrens, A., Putnam, P. E., Abonia, J. P., Santos, J. and Rothenberg, M. E. (2010). Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis. Gut 59(1): 12-20.
  92. Ingerski, L. M., Modi, A. C., Hood, K. K., Pai, A. L., Zeller, M., Piazza-Waggoner, C., Driscoll, K. A., Rothenberg, M. E., Franciosi, J. and Hommel, K. A. (2010). Health-related quality of life across pediatric chronic conditions. J Pediatr 156(4): 639-644.
  93. Uygungil, B., Bleesing, J. J., Risma, K. A., McNeal, M. M. and Rothenberg, M. E. (2010). Persistent rotavirus vaccine shedding in a new case of severe combined immunodeficiency: A reason to screen. J Allergy Clin Immunol 125(1): 270-271.
  94. Gao, P. S., Shimizu, K., Grant, A. V., Rafaels, N., Zhou, L. F., Hudson, S. A., Konno, S., Zimmermann, N., Araujo, M. I., Ponte, E. V., Cruz, A. A., Nishimura, M., Su, S. N., Hizawa, N., Beaty, T. H., Mathias, R. A., Rothenberg, M. E., Barnes, K. C. and Bochner, B. S. (2010). Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma. Eur J Hum Genet 18(6): 713-719.
  95. Herbert, D. R., Yang, J. Q., Hogan, S. P., Groschwitz, K., Khodoun, M., Munitz, A., Orekov, T., Perkins, C., Wang, Q., Brombacher, F., Urban, J. F., Jr., Rothenberg, M. E. and Finkelman, F. D. (2009). Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. J Exp Med 206(13): 2947-2957.
  96. Ogbogu, P. U., Bochner, B. S., Butterfield, J. H., Gleich, G. J., Huss-Marp, J., Kahn, J. E., Leiferman, K. M., Nutman, T. B., Pfab, F., Ring, J., Rothenberg, M. E., Roufosse, F., Sajous, M. H., Sheikh, J., Simon, D., Simon, H. U., Stein, M. L., Wardlaw, A., Weller, P. F. and Klion, A. D. (2009). Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy. J Allergy Clin Immunol 124(6): 1319-1325 e1313.
  97. Rothenberg, M. E. and Daeron, M. (2009). Hypersensitivity and allergy: from mice to men. Curr Opin Immunol 21(6): 658-659.
  98. Kottyan, L. C., Collier, A. R., Cao, K. H., Niese, K. A., Hedgebeth, M., Radu, C. G., Witte, O. N., Khurana Hershey, G. K., Rothenberg, M. E. and Zimmermann, N. (2009). Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner. Blood 114(13): 2774-2782.
  99. Rothenberg, M. E. (2009). Biology and treatment of eosinophilic esophagitis. Gastroenterology 137(4): 1238-1249.
  100. Takeda, A., Baffi, J. Z., Kleinman, M. E., Cho, W. G., Nozaki, M., Yamada, K., Kaneko, H., Albuquerque, R. J., Dridi, S., Saito, K., Raisler, B. J., Budd, S. J., Geisen, P., Munitz, A., Ambati, B. K., Green, M. G., Ishibashi, T., Wright, J. D., Humbles, A. A., Gerard, C. J., Ogura, Y., Pan, Y., Smith, J. R., Grisanti, S., Hartnett, M. E., Rothenberg, M. E. and Ambati, J. (2009). CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature 460(7252): 225-230.
  101. Yamada, Y., Cancelas, J. A. and Rothenberg, M. E. (2009). Murine model of hypereosinophilic syndromes/chronic eosinophilic leukemia. Int Arch Allergy Immunol 149 Suppl 1: 102-107.
  102. Niese, K. A., Collier, A. R., Hajek, A. R., Cederbaum, S. D., O'Brien, W. E., Wills-Karp, M., Rothenberg, M. E. and Zimmermann, N. (2009). Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice. BMC immunology 10(1): 33.
  103. Putnam, P. E. and Rothenberg, M. E. (2009). Eosinophilic esophagitis: concepts, controversies, and evidence. Curr Gastroenterol Rep 11(3): 220-225.
  104. Lu, T. X., Munitz, A. and Rothenberg, M. E. (2009). MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol 182(8): 4994-5002.
  105. Rothenberg, M. E. (2009). Molecular diagnostics and treatment of patients with the hypereosinophilic syndrome. Clin Adv Hematol Oncol 7(1): 43-44.
  106. Blanchard, C. and Rothenberg, M. E. (2009). Biology of the eosinophil. Adv Immunol 101: 81-121.
  107. Munitz, A., Seidu, L., Cole, E. T., Ahrens, R., Hogan, S. P. and Rothenberg, M. E. (2009). Resistin-like molecule alpha decreases glucose tolerance during intestinal inflammation. J Immunol 182(4): 2357-2363.
  108. Pentiuk, S., Putnam, P. E., Collins, M. H. and Rothenberg, M. E. (2009). Dissociation between symptoms and histological severity in pediatric eosinophilic esophagitis. Journal of pediatric gastroenterology and nutrition 48(2): 152.
  109. Miyazaki, D., Nakamura, T., Ohbayashi, M., Kuo, C. H., Komatsu, N., Yakura, K., Tominaga, T., Inoue, Y., Higashi, H., Murata, M., Takeda, S., Fukushima, A., Liu, F. T., Rothenberg, M. E. and Ono, S. J. (2009). Ablation of type I hypersensitivity in experimental allergic conjunctivitis by eotaxin-1/CCR3 blockade. Int Immunol 21(2): 187-201.
  110. Blanchard, C. and Rothenberg, M. E. (2009). Chemotactic factors associated with eosinophilic gastrointestinal diseases. Immunol Allergy Clin North Am 29(1): 141-148, xi.
  111. Rothenberg, M. E. and Stein, M. (2009). Reply. J Allergy Clin Immunol 123:269-70.
  112. Brandt, E. B., Munitz, A., Orekov, T., Mingler, M. K., McBride, M., Finkelman, F. D. and Rothenberg, M. E. (2009). Targeting IL-4/IL-13 signaling to alleviate oral allergen-induced diarrhea. J Allergy Clin Immunol 123(1): 53-58.

Book chapters

  1. Wen, T. and Rothenberg, M. E. Eosinophils. Mucosal Immunology 4th edition. Elsevier Science. (In press)
  2. Yoshiyuki, Y., Cancelas, J. A. and Rothenberg, M. E. Eosinophilic Leukemia Models. Eosinophils in Health and Disease. (In press)
  3. DeBrosse, C. W. and Rothenberg, M. E. Allergy and Eosinophil-associated Gastrointestinal Disorders. Current Opinions in Immunology. (In press)
  4. Rothenberg, M. E. (2014). Eosinophilic smdromes. In: Goldman, L. and Schafer, A. I. (eds). Goldman's Cecil Medicine, 25th Edition. Elsevier/Saunders.
  5. Rothenberg, M. E. Eosinophilic Gastroentrointestinal Disorders. (2013). In: Adkinson, N. F., Busse, W. W., Bochner, B. S., Holgate, S. T., Simons, F. E. R. and Lemanske, R. F. (eds). Middleton's Allergy: Principles and Practice, (8th Edition). Elsevier,1095-1104.
  6. Rothenberg, M. E. (2012). Eosinophilic smdromes. In: Goldman, L. and Schafer, A. I. (eds). Goldman's Cecil Medicine, 24th Edition. Elsevier/Saunders, 1118-1121.
  7. DeBrosse, C. W. and Rothenberg, M. E. (2012). Eosinophilia: Clinical Manifestations and Therapeutic Options. In: Holgate, S. T., Church, M. K., Broide, D. H. and Martinez, F. D. (eds). Allergy, 49‘ Edition. Elsevier/Saunders, 361-368.
  8. Rothenberg, M. E., Pentiuk, S. and Putnam, P. (2012). Gastroesophageal Reflux Disease and Eosinophilic Esophagitis in Children with Complex Airway Disease. In: Wilmott, R. W., Boat, T. F., Bush, A., Chernick, V., Deterding, R. R. and Ratjen, F. (eds). Kendig and Chemick's Disorders of the Respiratory Track in Children, 8th Edition. Elsevier/Saunder. 966-968.
  9. Davis, B. P. and Rothenberg, M. E. (2012). The Roles of Eosinophils in Human Disease: Eosinophils and GI Disease. In: Lee, I. l. and Rosenberg, H. F. (eds). Eosinophils in Health and Disease. Elsevier, 484-493.
  10. Sherrill, I. D. and Rothenberg, M. E. (2012). The Genetic Basis of Eosinophilic Esophagitis. In: Liacouras, C. A. and Markowitz, J. E. (eds). Eosinophilic Esophagitis. Clinical Gastroenterology. Springer, 97-106.
  11. Blanchard, C. and Rothenberg, M. E. (2009). Chemotactic Factors Associated with Eosinophilic Gastrointestinal Diseases. In: Furuta, G. T., Atkins, D. and Alam, R. (eds). Immunology and Allergy Clinics of North America. WB Saunders. 141-148.
  12. Rothenberg, M. E. (2008). Biology of Eosinophils. In: Adkinson, N. F., Busse, W. W., Bochner, B. S., Holgate, S. T., Simons, F. E. R., Lemanske, R. F. (eds). Middleton's Allergy: Principles and Practice, 7th Edition. Elsevier.
  13. Rothenberg, M. E. (2009). Eosinophilic Gastroenteropathies. In: Adkinson, Ir. N. F., Busse, W. W., Bochner, B. S., Holgate, S. T., Simons, F. E. R. and Lemanske, Ir. R. F. (eds). Middleton's Allergy: Principles and Practice, 7th Edition. Elsevier. 879-888.
  14. Rothenberg, M. E. and Furuta, G. T. (2009). Eosinophilic Esophagitis. In: Yamada, T. (ed), Alpers, D. H., Kalloo, A., Kaplowitz, N. and Owyang, C., Powell, D. (associate editors). Textbook of Gastroenterology (Sm Edition). Blackwell Publishing, 802-812.
  15. Li, Z. and Rothenberg, M. E. (2008). Eosinophil Associated Gastrointestinal Disorders IEGIDI. In: Rich, R. R., Shearer, W. T., Fleisher, T. A., Schroeder, H., Weyand, C., Frew, A. I. (eds). Clinical Immunology, 3"3 Edition. Martin Mellor Publishing Services.
  16. Fulkerson, P. C. and Rothenberg, M. E. (2008). Eosinophilia and Eosinophilic Disorders. In: Mahmoudi, M. (ed). Challenging Cases in Allergy and Immunology. Humana Press.
  17. Rothenberg, M. E. (2007). Eosinophilic Smdromes. In: Goldman, L. and Ausiello, D. (eds). Cecil Medicine: Expert Consult: Online and Print (Cecil Textbook of Medicine), 23th Edition. WB Saunders.
  18. Fulkerson, P. C. and Rothenberg, M. E. (2006). Chemokines CXC: CXCL9 lmigl. In: Laurent G. J., Shapiro, S. D. (eds). Encyclopedia of Respiratory Medicine. Elsevier Science. 398-401.
  19. Rothenberg, M. E. (2005). Eosinophils. In: Mestecky, I., Bienenstock, I., Lamm, M. E., Mayer, L., McGhee, I. R. and Strober, W. (eds). Mucosal Immunology, Volume I. Elsevier Science. 717-735.
  20. Rothenberg, M. E. (2003). Inflammatogg Effector Cells[Cell Migration. In: Leung, D. Y. M., Geha, R., Sampson, H. and Szefler, A. (eds). Pediatric Allergy: Principles and Practice. Mosby. 51-68.
  21. Guajardo, I. R. and Rothenberg, M. E. (2003). Eosinophilic Esophagjtis, Gastroenteritis, Gastroenterocolitis, and Colitis. In: Metcalfe, D., Sampson, H. and Simon, R. A. (eds). Food Allergy: Adverse Reactions to Foods and Food Additives, 3th Edition. Blackwell Publishing, 217-226.
  22. Zimmermann, N. and Rothenberg, M. E. (2003). Role of the Eotaxin Subfamily of Chemokines in Allergic Eosinophilic Inflammation. In: Eissa, N. T., Huston, D. P. and Lenfant, C. (eds). Lung Biology in Health and Disease: Therapeutic Targets of Airway Inflammation. Marcel Dekker, 421-463.
  23. Zimmermann, N. and Rothenberg, M. E. (2002). Therapeutic Targeting of Chemokines and Chemokine Receptors. In: Agosti, I., Sheffer, A. L. (eds). Biotherapeutic Approaches to Asthma. Marcel Dekker, 167-210.
  24. Rothenberg, M. E. (2002). Eotaxin. In: Creighton, T. E. (ed). The Encyclopedia of Molecular Medicine. Iohn Wiley & Sons, 1181-1185.
  25. Assa'ad, A. H., Spicer, R. L., Nelson, D. P., Zimmermann, N. and Rothenberg, M. E. (2000). Hypereosinophilic Syndromes. In: Marone, G. (ed). Human Eosinophils: Biologic and Clinical Aspects, Volume 76. AG Basel, 208-229.
  26. Zimmermann, N. and Rothenberg, M. E. (2000). Eosinophil Chemokines. In: Rothenberg, M. E. (ed). Chemokines in Allergic Disease. Marcel Dekker,151-171.
  27. Murphy, P. M. and Rothenberg, M. E. (2000). Chemokine Receptors. In: Rothenberg, M. E. (ed). Chemokines in Allergic Disease. Marcel Dekker, 53-66.
  28. Rothenberg, M. E. and Hogan, S. P. (2000). Introduction. In: Rothenberg, M. E. (ed). Chemokines in Allergic Disease. Marcel Dekker, 1-15.
  29. Rothenberg, M. E. (2000). Chemokine Knockout Mice. In: Proudfoot, A. (ed). Methods in Molecular Biology, Volume 138: Chemokine Protocols. New Jersey, 253-257.
  30. Rothenberg, M. E. Eotaxin. (1998). In: Aggarwal, B. (ed). Human Cytokines: Handbook for Basic and Clinical Research, Volume III. Blackwell Science, 383-399.
  31. Rothenberg, M. E. and Austen, K. F. (1989). Influence of the fibroblast environment on the structure of mast cell proteoglycans. Ann N YAcad Sci., 233-244.
  32. Rothenberg, M. E. and Austen, K. F. (1988). Reglation of human eosinophil phenotype. In: Hadden, J. W. et al. (eds). Advances in Immunopharmacology 4. Pergamon Press, 231-237.

Author/ Editor textbooks

  1. Rothenberg, M. E., editor of Chemokines in Allergic Diseases, Marcel Dekker, 1999.
Protocols by Marc E. Rothenberg
  1. Bone Marrow Derived Eosinophil Cultures