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Zuoxiang Xiao


Ph.D. in Oncology, Zhejiang University, China, 2003

Current position

Senior Research Fellow in Cancer and Inflammation Program, NCI-Frederick/NIH, Frederick, Maryland


  1. Xiao, Z., Jiang, Q., Willette-Brown, J., Xi, S., Zhu, F., Burkett, S., Back, T., Song, N. Y., Datla, M., Sun, Z., Goldszmid, R., Lin, F., Cohoon, T., Pike, K., Wu, X., Schrump, D. S., Wong, K. K., Young, H. A., Trinchieri, G., Wiltrout, R. H. and Hu, Y. (2013). The pivotal role of IKKalpha in the development of spontaneous lung squamous cell carcinomas. Cancer Cell 23(4): 527-540.
  2. Xia, X.*, Liu, S.*, Xiao, Z.*, Zhu, F., Song, N. Y., Zhou, M., Liu, B., Shen, J., Nagashima, K., Veenstra, T. D., Burkett, S., Datla, M., Willette-Brown, J., Shen, H. and Hu, Y. (2013). An IKKalpha-nucleophosmin axis utilizes inflammatory signaling to promote genome integrity. Cell Rep 5(5): 1243-1255. *These authors contributed equally
  3. Xiao, Z., Jiang, Q., Willette-Brown, J. and Hu, Y. (2013). Mouse model resembling human lung cancer. Oncotarget. (Epub ahead of print)
  4. Xiao, Z., Mohamood, A. S., Uddin, S., Gutfreund, R., Nakata, C., Marshall, A., Kimura, H., Caturegli, P., Womer, K. L., Huang, Y., Jie, C., Chakravarti, S., Schneck, J. P., Yagita, H. and Hamad, A. R. (2011). Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development. Am J Pathol 179(2): 725-732.
  5. Hamad, A. R., Xiao, Z., Li, M., Schneck, J., and Mohamood, A. (2009). Correlating expression of syndecan 1, a novel marker for certain thymocyte with development into unique alpha/beta T cell lineages. J Immunol 182: 86-93.
  6. Stanley, B. J., Ehrlich, E. S., Short, L., Yu, Y., Xiao, Z., Yu, X. F. and Xiong, Y. (2008). Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly. J Virol 82(17): 8656-8663.
  7. Mohamood, A. S., Bargatze, D., Xiao, Z., Jie, C., Yagita, H., Ruben, D., Watson, J., Chakravarti, S., Schneck, J. P. and Hamad, A. R. (2008). Fas-mediated apoptosis regulates the composition of peripheral alphabeta T cell repertoire by constitutively purging out double negative T cells. PLoS One 3(10): e3465.
  8. Xiao, Z., Ehrlich, E., Luo, K., Xiong, Y. and Yu, X. F. (2007). Zinc chelation inhibits HIV Vif activity and liberates antiviral function of the cytidine deaminase APOBEC3G. FASEB J 21(1): 217-222.
  9. Xiao, Z., Xiong, Y., Zhang, W., Tan, L., Ehrlich, E., Guo, D. and Yu, X. F. (2007). Characterization of a novel Cullin5 binding domain in HIV-1 Vif. J Mol Biol 373(3): 541-550.
  10. Mohamood, A. S., Guler, M. L., Xiao, Z., Zheng, D., Hess, A., Wang, Y., Yagita, H., Schneck, J. P. and Hamad, A. R. (2007). Protection from autoimmune diabetes and T-cell lymphoproliferation induced by FasL mutation are differentially regulated and can be uncoupled pharmacologically. Am J Pathol 171(1): 97-106.
  11. Yu, Y.*, Xiao, Z.*, Ehrlich, E. S., Yu, X. and Yu, X. F. (2004). Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines. Genes Dev 18(23): 2867-2872. *These authors contributed equally
  12. Luo, K., Ehrlich, E., Xiao, Z., Zhang, W., Ketner, G. and Yu, X. F. (2007). Adenovirus E4orf6 assembles with Cullin5-ElonginB-ElonginC E3 ubiquitin ligase through an HIV/SIV Vif-like BC-box to regulate p53. FASEB J 21(8): 1742-1750.
  13. Luo, K., Wang, T., Liu, B., Tian, C., Xiao, Z., Kappes, J. and Yu, X. F. (2007). Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation. J Virol 81(13): 7238-7248.
  14. Xiao, Z., Ehrlich, E., Yu, Y., Luo, K., Wang, T., Tian, C. and Yu, X. F. (2006). Assembly of HIV-1 Vif-Cul5 E3 ubiquitin ligase through a novel zinc-binding domain-stabilized hydrophobic interface in Vif. Virology 349(2): 290-299.
  15. Luo, K., Xiao, Z., Ehrlich, E., Yu, Y., Liu, B., Zheng, S. and Yu, X. F. (2005). Primate lentiviral virion infectivity factors are substrate receptors that assemble with cullin 5-E3 ligase through a HCCH motif to suppress APOBEC3G. Proc Natl Acad Sci U S A 102(32): 11444-11449.
  16. Luo, K., Liu, B., Xiao, Z., Yu, Y., Yu, X., Gorelick, R. and Yu, X. F. (2004). Amino-terminal region of the human immunodeficiency virus type 1 nucleocapsid is required for human APOBEC3G packaging. J Virol 78(21): 11841-11852.
  17. Zheng, S., Xiao, Z. X., Pan, Y. L., Han, M. Y. and Dong, Q. (2003). Continuous release of interleukin 12 from microencapsulated engineered cells for colon cancer therapy. World J Gastroenterol 9(5): 951-955.
  18. Zheng, S., Han, M. Y., Xiao, Z. X., Peng, J. P. and Dong, Q. (2003). Clinical significance of vascular endothelial growth factor expression and neovascularization in colorectal carcinoma. World J Gastroenterol 9(6): 1227-1230.
Protocols by Zuoxiang Xiao
  1. Protocol for Preparation of Nuclear Protein from Mouse Lungs
  2. Protocol for Macrophage Depletion from Mice