Welcome guest, Sign in

Home


Mario M. Zaiss

Education

Ph.D. in Immunology, Institute of Rheumatology and Immunology, University of Erlangen-Nuremberg, Germany, 2009

Current position

Scientific Collaborator, Global Health Institute, Laboratory of Intestinal Immunology, École Polytechnique Fédérale de Lausanne, Switzerland

Publications

  1. Bozec, A.*, Zaiss, M. M.*, Kagwiria, R., Voll, R., Rauh, M., Chen, Z., Mueller-Schmucker, S., Kroczek, R. A., Heinzerling, L., Moser, M., Mellor, A. L., David, J. P. and Schett, G. (2014). T Cell Costimulation Molecules CD80/86 Inhibit Osteoclast Differentiation by Inducing the IDO/Tryptophan Pathway. Sci Transl Med 6(235): 235ra260.
  2. Boyle, D. L., Hammaker, D., Edgar, M., Zaiss, M. M., Teufel, S., David, J. P., Schett, G. and Firestein, G. S. (2014). Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss. PLoS One 9(1): e84818.
  3. Zaiss, M. M., Maslowski, K. M., Mosconi, I., Guenat, N., Marsland, B. J. and Harris, N. L. (2013). IL-1beta suppresses innate IL-25 and IL-33 production and maintains helminth chronicity. PLoS Pathog 9(8): e1003531.
  4. Scholtysek, C., Katzenbeisser, J., Fu, H., Uderhardt, S., Ipseiz, N., Stoll, C., Zaiss, M. M., Stock, M., Donhauser, L., Bohm, C., Kleyer, A., Hess, A., Engelke, K., David, J. P., Djouad, F., Tuckermann, J. P., Desvergne, B., Schett, G. and Kronke, G. (2013). PPARbeta/delta governs Wnt signaling and bone turnover. Nat Med 19(5): 608-613.
  5. Mosconi, I., Geuking, M. B., Zaiss, M. M., Massacand, J. C., Aschwanden, C., Kwong Chung, C. K., McCoy, K. D. and Harris, N. L. (2013). Intestinal bacteria induce TSLP to promote mutualistic T-cell responses. Mucosal Immunol 6(6): 1157-1167.
  6. Herbst, T., Esser, J., Prati, M., Kulagin, M., Stettler, R., Zaiss, M. M., Hewitson, J. P., Merky, P., Verbeek, J. S., Bourquin, C., Camberis, M., Prout, M., Maizels, R. M., Le Gros, G. and Harris, N. L. (2012). Antibodies and IL-3 support helminth-induced basophil expansion. Proc Natl Acad Sci U S A 109(37): 14954-14959.
  7. Zwerina, K., Koenders, M., Hueber, A., Marijnissen, R. J., Baum, W., Heiland, G. R., Zaiss, M., McLnnes, I., Joosten, L., van den Berg, W., Zwerina, J. and Schett, G. (2012). Anti IL-17A therapy inhibits bone loss in TNF-alpha-mediated murine arthritis by modulation of the T-cell balance. Eur J Immunol 42(2): 413-423.
  8. Guckel, E., Frey, S., Zaiss, M. M., Schett, G., Ghosh, S. and Voll, R. E. (2011). Cell-intrinsic NF-kappaB activation is critical for the development of natural regulatory T cells in mice. PLoS One 6(5): e20003.
  9. Zaiss, M. M., Kurowska-Stolarska, M., Bohm, C., Gary, R., Scholtysek, C., Stolarski, B., Reilly, J., Kerr, S., Millar, N. L., Kamradt, T., McInnes, I. B., Fallon, P. G., David, J. P., Liew, F. Y. and Schett, G. (2011). IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss. J Immunol 186(11): 6097-6105.
  10. Luther, J., Driessler, F., Megges, M., Hess, A., Herbort, B., Mandic, V., Zaiss, M. M., Reichardt, A., Zech, C., Tuckermann, J. P., Calkhoven, C. F., Wagner, E. F., Schett, G. and David, J. P. (2011). Elevated Fra-1 expression causes severe lipodystrophy. J Cell Sci 124(Pt 9): 1465-1476.
  11. Schulze, J., Bickert, T., Beil, F. T., Zaiss, M. M., Albers, J., Wintges, K., Streichert, T., Klaetschke, K., Keller, J., Hissnauer, T. N., Spiro, A. S., Gessner, A., Schett, G., Amling, M., McKenzie, A. N., Horst, A. K. and Schinke, T. (2011). Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells. J Bone Miner Res 26(4): 704-717.
  12. Zaiss, M. M. (2010). The Role of Regulatory T Cells in Bone Homeostasis-Linking Cells from the Immune System with Bone Cells. SVH Publishing
  13. Zaiss, M. M., Sarter, K., Hess, A., Engelke, K., Bohm, C., Nimmerjahn, F., Voll, R., Schett, G. and David, J. P. (2010). Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation. Arthritis Rheum 62(8): 2328-2338.
  14. Kronke, G., Uderhardt, S., Kim, K. A., Stock, M., Scholtysek, C., Zaiss, M. M., Surmann-Schmitt, C., Luther, J., Katzenbeisser, J., David, J. P., Abdollahi-Roodsaz, S., Tran, K., Bright, J. M., Binnerts, M. E., Akhmetshina, A., Bohm, C., Distler, J. H., Joosten, L. A., Schett, G. and Abo, A. (2010). R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway. Arthritis Rheum 62(8): 2303-2312.
  15. Rauch, A., Seitz, S., Baschant, U., Schilling, A. F., Illing, A., Stride, B., Kirilov, M., Mandic, V., Takacz, A., Schmidt-Ullrich, R., Ostermay, S., Schinke, T., Spanbroek, R., Zaiss, M. M., Angel, P. E., Lerner, U. H., David, J. P., Reichardt, H. M., Amling, M., Schutz, G. and Tuckermann, J. P. (2010). Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab 11(6): 517-531.
  16. Zaiss, M. M., Frey, B., Hess, A., Zwerina, J., Luther, J., Nimmerjahn, F., Engelke, K., Kollias, G., Hunig, T., Schett, G. and David, J. P. (2010). Regulatory T cells protect from local and systemic bone destruction in arthritis. J Immunol 184(12): 7238-7246.
  17. Kronke, G., Katzenbeisser, J., Uderhardt, S., Zaiss, M. M., Scholtysek, C., Schabbauer, G., Zarbock, A., Koenders, M. I., Axmann, R., Zwerina, J., Baenckler, H. W., van den Berg, W., Voll, R. E., Kuhn, H., Joosten, L. A. and Schett, G. (2009). 12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis. J Immunol 183(5): 3383-3389.
  18. Papadakis, I. E., Zaiss, M. M., Kyriakou, Y., Georgiou, G., Divanach, P. and Mylonas, C. C. (2009). Histological evaluation of the elimination of Artemia nauplii from larval rearing protocols on the digestive system ontogeny of shi drum (Umbrina cirrosa L.). Aquaculture 286(1): 45-52.
  19. Mylonas, C. C., Pavlidis, M., Papandroulakis, N., Zaiss, M. M., Tsafarakis, D., Papadakis, I. E. and Varsamos, S. (2009). Growth performance and osmoregulation in the shi drum (Umbrina cirrosa) adapted to different environmental salinities. Aquaculture 287(1): 203-210.
  20. Bohm, C., Hayer, S., Kilian, A., Zaiss, M. M., Finger, S., Hess, A., Engelke, K., Kollias, G., Kronke, G., Zwerina, J., Schett, G. and David, J. P. (2009). The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss. J Immunol 183(9): 5938-5947.
  21. Axmann, R., Herman, S., Zaiss, M., Franz, S., Polzer, K., Zwerina, J., Herrmann, M., Smolen, J. and Schett, G. (2008). CTLA-4 directly inhibits osteoclast formation. Ann Rheum Dis 67(11): 1603-1609.
  22. Zaiss, M. M., Axmann, R., Zwerina, J., Polzer, K., Guckel, E., Skapenko, A., Schulze-Koops, H., Horwood, N., Cope, A. and Schett, G. (2007). Treg cells suppress osteoclast formation: a new link between the immune system and bone. Arthritis Rheum 56(12): 4104-4112.
  23. Zaiss, M. M., Papadakis, I. E., Maingot, E., Divanach, P. and Mylonas, C. C. (2006). Ontogeny of the digestive tract in shi drum (Umbrina cirrosa L.) reared using the mesocosm larval rearing system. Aquaculture 260(1): 357-368.
Protocols by Mario M. Zaiss
  1. Identification of Helminth-induced Type 2 CD4+ T Cells and ILC2s
  2. In vitro Inflammasome Assay