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Leizhen   Wei

Leizhen Wei


Ph.D., Tohoku University, 2008
Ph.D., China Medical University, 2006
M.D., China Medical University, 1999

Current position

Research Associate, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh

Publications (since 2001)

  1. Matsuzawa, A., Kanno, S., Nakayama, M., Mochiduki, H., Wei, L., Shimaoka, T., Furukawa, Y., Kato, K., Shibata, S., Yasui, A., Ishioka, C. and Chiba, N. (2014). The BRCA1/BARD1-interacting protein OLA1 functions in centrosome regulation. Mol Cell 53(1): 101-114.
  2. Nakajima, S., Lan, L., Wei, L., Hsieh, C. L., Rapic-Otrin, V., Yasui, A. and Levine, A. S. (2014). Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks. PLoS One 9(1): e84899.
  3. Lan, L.**, Nakajima, S.*, Wei, L.*, Sun, L., Hsieh, C. L., Sobol, R. W., Bruchez, M., Van Houten, B., Yasui, A. and Levine, A. S. (2014). Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin. Nucleic Acids Res 42(4): 2330-2345. (*Co-first, **Co-respondence)
  4. Benitez, A., Yuan, F., Nakajima, S., Wei, L., Qian, L., Myers, R., Hu, J. J., Lan, L. and Zhang, Y. (2014). Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein. Nucleic Acids Res 42(3): 1671-1683.
  5. Wei, L., Nakajima, S., Hsieh, C. L., Kanno, S., Masutani, M., Levine, A. S., Yasui, A. and Lan, L. (2013). Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose). J Cell Sci 126(Pt 19): 4414-4423.
  6. Gao, M.*, Rendtlew Danielsen, J.*, Wei, L. Z.*, Zhou, D. P., Xu, Q., Li, M. M., Wang, Z. Q., Tong, W. M. and Yang, Y. G. (2012). A novel role of human holliday junction resolvase GEN1 in the maintenance of centrosome integrity. PLoS One 7(11): e49687. (*Equal contributor)
  7. Wei, L., Lan, L., Yasui, A., Tanaka, K., Saijo, M., Matsuzawa, A., Kashiwagi, R., Maseki, E., Hu, Y., Parvin, J. D., Ishioka, C. and Chiba, N. (2011). BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein. Cancer Sci 102(10): 1840-1847.
  8. Wei, L., Lan, L., Hong, Z., Yasui, A., Ishioka, C. and Chiba, N. (2008). Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80. Mol Cell Biol 28(24): 7380-7393.
  9. Li, Z., Wei, L. Z. and Wang, Y. J. (2007). Construction,identification, and expression of pEGFP-RECK expression vector in human glioma cell line. Journal of China Medical University Vol. 4, 389-391.
  10. Li, Z., Sun, T., Wei, L. Z., Wang, Y. J. and Zhang, C. D. (2006). RECK expression in gliomas and its clinical significance. Chinese Journal of Neurosurgery Vol.22 No.9, 550-552.
  11. Wei, L. Z., Li, Z., Sun, T. and Jin, C. L. (2004). Apoptosis in Wilms’ Tumor. Journal of China Medical University Vol. 1, 24-25.
  12. Hu, L., Jiang, Y. H., Shu, H., Wei, L. Z. and Ren, C. S. (2004). WT1 expression alters tumorigenicity of the G401 cell line. Journal of Modern Oncology Vol. 2, 92-94.
  13. Lin, C. K., Jiang, L., Jin, C. L., Wei, L. Z., Lu, Y. and Sun, K. (2004). The Application of PCR-DGGE in Anteparturn Gene Diagnosis of PUK. Chinese Journal of Laboratory Medicine Vol.27 No.1, 29.
  14. Cui, R., Zhao, H., Cong, C. H. and Wei, L. Z. (2004). The Expression of-ΚB When Hypoxic-Reperfusion Brain Injury in Rat. Chin J Anesthesiol Vol 24 (2), 142-143.
  15. Hu, L. Jiang, Y. H., Wei, L. Z. and Ren, C. S. (2003). The expression of WT1 and EGR-1 in Wilms’Tumor. Chin J Public Health Vol. 9 (10), 1230-1231.
  16. Wei, L. Z., Li, Z., Sun, T. and Jin, C. L. (2003). Apoptosis and Expression of Bcl-2 in Wilms’Tumor. Chinese Journal of Tumor Indulgent Therapy Vol. 2 (2), 86-88.
  17. Sun, T., Liu, Y. R., Wei, L. Z. and Gao, Y. L. (2003). Clinical Significance of p27kip1 Expression in Right-sided Colon Cancer. Chinese Journal of Tumor Indulgent Therapy Vol. 2 (2), 89-91.
  18. Hu, L. and Wei, L. Z. (2001). Risk Evaluation of Genetical Breast Cancer. Journal of Chinese Medical Abstracts (Oncology) Vol. 15 (3), 84-86.
Protocols by Leizhen Wei
  1. Novel Method for Site-specific Induction of Oxidative DNA Damage to Study Recruitment of Repair Proteins to Heterochromatin and Euchromatin