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Hermann M. Schätzl

Education

Ph.D. in Virology/Retrovirology, University of Munich, Germany

Current position

Professor in Prion Biology and Immunology, Faculty of Veterinary Medicine, Department of Comparative Biology & Experimental Medicine, at the University of Calgary (since 2013)
Professor (adjunct) and former Wyoming Endowed Excellence Chair, Department of Veterinary Sciences and of Molecular Biology, University of Wyoming Laramie, Wyoming, USA (since 2013)

Publications

Original peer reviewed references (since 2009)

  1. Leidel, F., Eiden, M., Geissen, M., Hirschberger, T., Tavan, P., Giese, A., Kretzschmar, H. A., Schätzl, H. and Groschup, M. H. (2014). Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo. Biochem Biophys Res Commun 445(1): 23-29.
  2. Hofmann, J. P., Denner, P., Nussbaum-Krammer, C., Kuhn, P. H., Suhre, M. H., Scheibel, T., Lichtenthaler, S. F., Schätzl, H. M., Bano, D. and Vorberg, I. M. (2013). Cell-to-cell propagation of infectious cytosolic protein aggregates. Proc Natl Acad Sci U S A 110(15): 5951-5956.
  3. John, T. R., Schätzl, H. M. and Gilch, S. (2013). Early detection of chronic wasting disease prions in urine of pre-symptomatic deer by real-time quaking-induced conversion assay. Prion 7(3): 253-258.
  4. Kyle, L. M., John, T. R., Schätzl, H. M. and Lewis, R. V. (2013). Introducing a rigid loop structure from deer into mouse prion protein increases its propensity for misfolding in vitro. PLoS One 8(6): e66715.
  5. Taguchi, Y., Mistica, A. M., Kitamoto, T. and Schätzl, H. M. (2013). Critical significance of the region between Helix 1 and 2 for efficient dominant-negative inhibition by conversion-incompetent prion protein. PLoS Pathog 9(6): e1003466.
  6. Taguchi, Y. and Schätzl, H. M. (2013). Identifying critical sites of PrP-PrP interaction in prion-infected cells by dominant-negative inhibition. Prion 7(6). (Epub ahead of print)
  7. Genzel-Boroviczeny, O., Jager, G. and Schätzl, H. M. (2012). Parvovirus B19 and necrotizing enterocolitis in neonates. J Pediatr 160(5): 887; author reply 887-888.
  8. Schneider, M., Ackermann, K., Stuart, M., Wex, C., Protzer, U., Schätzl, H. M. and Gilch, S. (2012). Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain. J Virol 86(18): 10112-10122.
  9. Franz, M., Eiden, M., Balkema-Buschmann, A., Greenlee, J., Schätzl, H., Fast, C., Richt, J., Hildebrandt, J. P. and Groschup, M. H. (2012). Detection of PrP(Sc) in peripheral tissues of clinically affected cattle after oral challenge with bovine spongiform encephalopathy. J Gen Virol 93(Pt 12): 2740-2748.
  10. Montag, J., Brameier, M., Schmadicke, A. C., Gilch, S., Schätzl, H. M. and Motzkus, D. (2012). A genome-wide survey for prion-regulated miRNAs associated with cholesterol homeostasis. BMC Genomics 13: 486.
  11. Klionsky, D. J. et al. (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8(4): 445-544.
  12. Lisa, S., Domingo, B., Martinez, J., Gilch, S., Llopis, J. F., Schätzl, H. M. and Gasset, M. (2012). Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms. J Biol Chem 287(44): 36693-36701.
  13. Karpuj, M. V., Gelibter-Niv, S., Tiran, A., Rambold, A., Tatzelt, J., Nunziante, M. and Schätzl, H. M. (2011). Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides. J Biol Chem 286(9): 6911-6917.
  14. Geissen, M., Leidel, F., Eiden, M., Hirschberger, T., Fast, C., Bertsch, U., Tavan, P., Giese, A., Kretzschmar, H., Schätzl, H. M. and Groschup, M. H. (2011). From high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease. ChemMedChem 6(10): 1928-1937.
  15. Leidel, F., Eiden, M., Geissen, M., Kretzschmar, H. A., Giese, A., Hirschberger, T., Tavan, P., Schätzl, H. M. and Groschup, M. H. (2011). Diphenylpyrazole-derived compounds increase survival time of mice after prion infection. Antimicrob Agents Chemother 55(10): 4774-4781.
  16. Nunziante, M., Ackermann, K., Dietrich, K., Wolf, H., Gadtke, L., Gilch, S., Vorberg, I., Groschup, M. and Schätzl, H. M. (2011). Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion protein. J Biol Chem 286(39): 33942-33953.
  17. Hoffmann, D., Reichhuber, C., Hörterer, H., Wolfarth, B., Nadas, K., Tora, C., Protzer, U. and Schätzl, H. M. (2010). Elevated EBV loads coupled with lower antibody titres in competitive endurance athletes. J. Med. Virol. 82, 446-451.
  18. Hoffmann, D., Seebach, J., Foley, B. T., Frosner, G., Nadas, K., Protzer, U. and Schätzl, H. M. (2010). Isolated norovirus GII.7 strain within an extended GII.4 outbreak. J Med Virol 82(6): 1058-1064.
  19. Kimura, T., Ishikawa, K., Sakasegawa, Y., Teruya, K., Sata, T., Schätzl, H. and Doh-Ura, K. (2010). GABAA receptor subunit beta1 is involved in the formation of protease-resistant prion protein in prion-infected neuroblastoma cells. FEBS Lett. 584, 1193-1198.
  20. Geissen, M., Mella, H., Saalmüller, A. Proft, J., Pfaff, E., Schätzl, H. and Groschup M. H. (2009). Systematic serial insertion of a heptapeptide sequence into the prion protein influences its authentic glycosylation, cellular, trafficking and convertibility. Infect. Disord. Drug Targets 9, 40-47.
  21. Krammer, C., Kryndushkin, D., Suhre, M.H., Kremmer, E., Hofmann, A., Pfeifer, A., Scheibel, T., Wickner, R., Schätzl, H.M., Vorberg, I. (2009). The yeast Sup35NM domain propagates as a prion in mammalian cells. PNAS 106, 462-467.
  22. Heiseke, A., Aguib, Y., Riemer, C., Baier, M. and Schätzl, H. M. (2009). Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy. J Neurochem 109(1): 25-34.
  23. Aguib, Y., Heiseke, A., Gilch, S., Riemer, C., Baier, M., Schätzl, H. M. and Ertmer, A. (2009). Autophagy induction by trehalose counteracts cellular prion infection. Autophagy 5(3): 361-369.
  24. Bach, C., Gilch, S., Rost, R., Greenwood, A. D., Horsch, M., Hajj, G. N., Brodesser, S., Facius, A., Schadler, S., Sandhoff, K., Beckers, J., Leib-Mosch, C., Schätzl, H. M. and Vorberg, I. (2009). Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells. J Biol Chem 284(45): 31260-31269.
  25. Gilch, S., Bach, C., Lutzny, G., Vorberg, I. and Schätzl, H. M. (2009). Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation. Cell Mol Life Sci 66(24): 3979-3991.

Reviews

  1. Gilch, S., Chitoor, N., Taguchi, Y., Stuart, M., Jewell, J. E. and Schätzl, H. M. (2011). Chronic Wasting Disease. Top. Curr. Chem. 305, 51-77.
  2. Heiseke, A., Aguib, Y. and Schätzl, H. M. (2010). Autophagy, prion infection and their mutual interactions. Curr Issues Mol Biol 12(2): 87-97.
  3. Schätzl, H. M. (2009). Drug targets in prion diseases. Infect Disord Drug Targets 9(1): 1-2.
  4. Krammer, C., Vorberg, I., Schätzl, H. M. and Gilch, S. (2009). Therapy in prion diseases: from molecular and cellular biology to therapeutic targets. Infect Disord Drug Targets 9(1): 3-14.
  5. Gilch, S. and Schätzl, H. M. (2009). Aptamers against prion proteins and prions. Cell Mol Life Sci 66(15): 2445-2455.
  6. Krammer, C., Schätzl, H. M. and Vorberg, I. (2009). Prion-like propagation of cytosolic protein aggregates: insights from cell culture models. Prion 3(4): 206-212.
  7. Gilch, S., Krammer, C. and Schätzl, H. M. (2008). Targeting prion proteins in neurodegenerative disease. Expert Opin Biol Ther 8(7): 923-940.
  8. Tatzelt, J. and Schätzl, H. M. (2007). Molecular basis of cerebral neurodegeneration in prion diseases. FEBS J 274(3): 606-611.
  9. Schätzl, H. M. (2006). Therapie und Prophylaxe: vom Wunschdenken zur Realität. Nova Acta Leopoldina 347, 111-128.
  10. Schätzl, H. M. (2003). Present-day knowledge of BSE and Creutzfeldt-Jakob disease. Gesundheitswesen 65 Suppl 1: S13-19.
  11. Nunziante, M., Gilch, S. and Schätzl, H. M. (2003). Prion diseases: from molecular biology to intervention strategies. Chembiochem 4(12): 1268-1284.
  12. Gilch, S. and Schätzl, H. M. (2003). Promising developments bringing prion diseases closer to therapy and prophylaxis. Trends Mol Med 9(9): 367-369.
  13. Schätzl, H. M. (2002). Prion-Erkrankungen: Therapie und Prophylaxe in Sicht? BIOforum 25, 142-144.
  14. Schätzl, H. M. (2002). Therapeutic approaches against prion diseases. Nova Acta Leopoldina 327, 65-79.
  15. Schätzl, H. M. (2001). Spezies-Barriere und Prion-Erkrankungen. BIOforum 24, 106-109.
  16. Schätzl, H. M. (1998). The renaissance of prion diseases: Latest aspects. Fortschr. Fortbild. Med. 22, 275-282.
  17. Schatzl, H. M. (1995). Neurotrophic factors: ready to go? Trends Neurosci 18(11): 463-464.
  18. Schätzl, H. (1992). Virologische und diagnostische Aspekte der Hepatitis-C-Infektion. Der Bayer. Internist 4, 22-28.

Book chapters

  1. Schätzl, H. (1992). Das humane T-Zell lymphotrope Virus Typ I und II (HTLV-I/II). In: Hofmann (ed). Infektiologie. ecomed-Verlag; IV/4.18, pp. 1-6.
  2. Jilg, W., Bittner, R., Schätzl, H. and Schmidt, M. (1993). Erfahrungen mit der aktiven Schutzimpfung gegen Hepatitis A. In: Spiess, H. (ed). Immunprophylaxe gegen Hepatitis A. pp. 105-111.
  3. Schätzl, H. Methodik und Aussagekraft der Polymerase-Kettenreaktion (PCR). (1994). in: Maas, G. and Stück, B. (eds). Virushepatitis A bis E - Diagnose, Therapie, Prophylaxe. pp. 112-123.
  4. Schätzl, H. (1994). Significance of PCR in diagnosing viral hepatitis. Internat. Symposium Viral Hepatitis/Chile pp. 13-25.
  5. Schätzl, H. M. (2001). Phylogenetik des PrP. In: Hörnlimann, B. (ed). Spongiforme Enzephalopathien. pp. 91-97.
  6. Schätzl, H. M. (2003). Prione. In: Darai, G. (ed). Lexikon der Infektionskrankheiten. pp. 550-562.
  7. Nunziante, M., Gilch, S. and Schätzl, H. M. (2005). Insights into the cellular trafficking of prion proteins. In: Brown, D. (ed). Neurodegeneration and prion diseases. pp. 379-406.
  8. Schätzl, H. M. (2005). Der aktuelle Erkenntnisstand bei Prionkrankheiten. In: Eikmann, Christiansen, Exner, Kramer, H. (eds). Hygiene in Krankenhaus und Praxis. Kapitel 4.9.1 pp. 1-7.
  9. Schätzl, H. M. (2006). The phylogeny of mammalian and non-mammalian PrPs. In: Hörnlimann, B., Riesner, D. and Kretzschmar, H. (eds). Prions and Prion Diseases.
  10. Schätzl, H. M. (2009). Prionen. In: Doerr, H. W. and Gerlich, W. H. (eds). Medizinische Virologie pp. 708-716.
  11. Diemer, C. Schneider, M., Schätzl, H. M. and Gilch, S. (2010). Host cell-specific modulation of cell death by structural and accessory proteins. In: Lal, S. K. (ed). Molecular Biology of the SARS-Coronavirus pp. 231-245.
  12. Schätzl, H. M. (2013). Cellular mechanisms of propagation and clearance. In: Zou, W. Z. and Gambetti, P. (eds). Prions and Prion Diseases. pp 147-160.

Author/Editor textbooks

  1. Modrow, S., Falke, D., Truyen, U., Schätzl, H. (2010). Molekulare Virologie, Third (German) edition.
  2. Modrow, S., Falke, D., Truyen, U., Schatzl, H. (2013). Molecular Virology, First (English) edition. Springer.


Protocols by Hermann M. Schätzl
  1. Small-scale Subcellular Fractionation with Sucrose Step Gradient
  2. Small-scale Triton X-114 Extraction of Hydrophobic Proteins