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Christian Roth

Education

Ph.D. in Structural Biology, University of Leipzig, Germany, 2013

Current position

PostDoc, University of York, UK (since 06/2013)

Publications

  1. Darby, J. F., Landström, J., Roth, C., He, Y., Davies, G. J. and Hubbard, R. E. (2014). Discovery of Selective Small‐Molecule Activators of a Bacterial Glycoside Hydrolase. Angew Chem Int Ed Engl. (Epub ahead of print)
  2. He, Y., Roth, C., Turkenburg, J. P. and Davies, G. J. (2014). Three-dimensional structure of a Streptomyces sviceus GNAT acetyltransferase with similarity to the C-terminal domain of the human GH84 O-GlcNAcase. Acta Crystallogr D Biol Crystallogr 70(Pt 1): 186-195.
  3. Roth, C., Wei, R., Oeser, T., Then, J., Follner, C., Zimmermann, W. and Strater, N. (2014). Structural and functional studies on a thermostable polyethylene terephthalate degrading hydrolase from Thermobifida fusca. Appl Microbiol Biotechnol 98(18): 7815-7823.
  4. Roth, C., Groning, J. A., Kaschabek, S. R., Schlomann, M. and Strater, N. (2013). Crystal structure and catalytic mechanism of chloromuconolactone dehalogenase ClcF from Rhodococcus opacus 1CP. Mol Microbiol 88(2): 254-267.
  5. Roth, C., Kaschabek, S. R., Groning, J. A., Handrek, T., Schlomann, M. and Strater, N. (2012). Crystallization and preliminary characterization of chloromuconolactone dehalogenase from Rhodococcus opacus 1CP. Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 5): 591-595.
  6. Lincke, J., Lassig, D., Kobalz, M., Bergmann, J., Handke, M., Mollmer, J., Lange, M., Roth, C., Moller, A., Staudt, R. and Krautscheid, H. (2012). An isomorphous series of cubic, copper-based triazolyl isophthalate MOFs: linker substitution and adsorption properties. Inorg Chem 51(14): 7579-7586.
  7. Groning, J. A., Roth, C., Kaschabek, S. R., Strater, N. and Schlomann, M. (2012). Recombinant expression of a unique chloromuconolactone dehalogenase ClcF from Rhodococcus opacus 1CP and identification of catalytically relevant residues by mutational analysis. Arch Biochem Biophys 526(1): 69-77.
  8. Dahms, S. O., Kuester, M., Streb, C., Roth, C., Strater, N. and Than, M. E. (2013). Localization and orientation of heavy-atom cluster compounds in protein crystals using molecular replacement. Acta Crystallogr D Biol Crystallogr 69(Pt 2): 284-297.
  9. MüMuller, M. Q., Roth, C., Strater, N. and Sinz, A. (2008). Expression and purification of the ligand-binding domain of peroxisome proliferator-activated receptor alpha (PPARalpha). Protein Expr Purif 62(2): 185-189.
Protocols by Christian Roth
  1. Purification and Crystallization of Chloromuconolactone Dehalogenase ClcF from Rhodococcus opacus 1CP