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Asuka Nanbo


Ph.D., Department of Hygienic Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan, 1999

Current position

Associate Professor at Graduate School of Medicine, Hokkaido University, working with Prof. Yusuke Ohba on Ebolavirus and Epstein-Barr virus virology (10/2013-present)


  1. Fujioka, Y., Tsuda, M., Nanbo, A., Hattori, T., Sasaki, J., Sasaki, T., Miyazaki, T. and Ohba, Y. (2013). A Ca(2+)-dependent signalling circuit regulates influenza A virus internalization and infection. Nat Commun 4: 2763.
  2. Nanbo, A., Kawanishi, E., Yoshida, R. and Yoshiyama, H. (2013). Exosomes derived from Epstein-Barr virus-infected cells are internalized via caveola-dependent endocytosis and promote phenotypic modulation in target cells. J Virol 87(18): 10334-10347.
  3. Nanbo, A., Watanabe, S., Halfmann, P. and Kawaoka, Y. (2013). The spatio-temporal distribution dynamics of Ebola virus proteins and RNA in infected cells. Sci Rep 3: 1206.
  4. Nanbo, A., Terada, H., Kachi, K., Takada, K. and Matsuda, T. (2012). Roles of cell signaling pathways in cell-to-cell contact-mediated Epstein-Barr virus transmission. J Virol 86(17): 9285-9296.
  5. Togi, S., Ikeda, O., Kamitani, S., Nakasuji, M., Sekine, Y., Muromoto, R., Nanbo, A., Oritani, K., Kawai, T., Akira, S. and Matsuda, T. (2011). Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4). J Biol Chem 286(21): 19170-19177.
  6. Ikeda, O., Mizushima, A., Sekine, Y., Yamamoto, C., Muromoto, R., Nanbo, A., Oritani, K., Yoshimura, A. and Matsuda, T. (2011). Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells. Cancer Sci 102(4): 756-761.
  7. Muromoto, R., Kuroda, M., Togi, S., Sekine, Y., Nanbo, A., Shimoda, K., Oritani, K. and Matsuda, T. (2010). Functional involvement of Daxx in gp130-mediated cell growth and survival in BaF3 cells. Eur J Immunol 40(12): 3570-3580.
  8. Ikeda, O., Sekine, Y., Mizushima, A., Nakasuji, M., Miyasaka, Y., Yamamoto, C., Muromoto, R., Nanbo, A., Oritani, K., Yoshimura, A. and Matsuda, T. (2010). Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells. J Biol Chem 285(49): 38093-38103.
  9. Nanbo, A., Imai, M., Watanabe, S., Noda, T., Takahashi, K., Neumann, G., Halfmann, P. and Kawaoka, Y. (2010). Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner. PLoS Pathog 6(9): e1001121.
  10. Ikeda, O., Togi, S., Kamitani, S., Muromoto, R., Sekine, Y., Nanbo, A., Fujimuro, M. and Matsuda, T. (2009). Silencing mediator of retinoic acid and thyroid hormone receptor regulates enhanced activation of signal transducer and activator of transcription 3 by epstein-barr virus-derived epstein-barr nuclear antigen 2. Biol Pharm Bull 32(7): 1283-1285.
  11. Ikeda, O., Sekine, Y., Mizushima, A., Oritani, K., Yasui, T., Fujimuro, M., Muromoto, R., Nanbo, A. and Matsuda, T. (2009). BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1. FEBS Lett 583(10): 1567-1574.
  12. Muromoto, R., Taira, N., Ikeda, O., Shiga, K., Kamitani, S., Togi, S., Kawakami, S., Sekine, Y., Nanbo, A., Oritani, K. and Matsuda, T. (2009). The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation. Biochem Biophys Res Commun 382(1): 63-68.
  13. Li, Z., Watanabe, T., Hatta, M., Watanabe, S., Nanbo, A., Ozawa, M., Kakugawa, S., Shimojima, M., Yamada, S., Neumann, G. and Kawaoka, Y. (2009). Mutational analysis of conserved amino acids in the influenza A virus nucleoprotein. J Virol 83(9): 4153-4162.
  14. Togi, S., Kamitani, S., Kawakami, S., Ikeda, O., Muromoto, R., Nanbo, A. and Matsuda, T. (2009). HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A. Biochem Biophys Res Commun 379(2): 616-620.
  15. Nanbo, A., Sugden, A. and Sugden, B. (2007). The coupling of synthesis and partitioning of EBV's plasmid replicon is revealed in live cells. EMBO J 26(19): 4252-4262.
  16. Nanbo, A., Yoshiyama, H. and Takada, K. (2005). Epstein-Barr virus-encoded poly(A)- RNA confers resistance to apoptosis mediated through Fas by blocking the PKR pathway in human epithelial intestine 407 cells. J Virol 79(19): 12280-12285.
  17. Nanbo, A., Inoue, K., Adachi-Takasawa, K. and Takada, K. (2002). Epstein-Barr virus RNA confers resistance to interferon-alpha-induced apoptosis in Burkitt's lymphoma. EMBO J 21(5): 954-965.
  18. Maruo, S., Nanbo, A. and Takada, K. (2001). Replacement of the Epstein-Barr virus plasmid with the EBER plasmid in Burkitt's lymphoma cells. J Virol 75(20): 9977-9982.
  19. Nishimura, H., Gogami, A., Miyagawa, Y., Nanbo, A., Murakami, Y., Baba, T. and Nagasawa, S. (2001). Bactericidal/permeability-increasing protein promotes complement activation for neutrophil-mediated phagocytosis on bacterial surface. Immunology 103(4): 519-525.
  20. Nanbo, A., Nishimura, H., Muta, T. and Nagasawa, S. (1999). Lipopolysaccharide stimulates HepG2 human hepatoma cells in the presence of lipopolysaccharide-binding protein via CD14. Eur J Biochem 260(1): 183-191.
  21. Nanbo, A., Nishimura, H. and Nagasawa, S. (1997). Lipopolysaccharide binding protein from normal human plasma purified with high efficiency. Protein Expr Purif 10(1): 55-60.


  1. *Iizasa, H., †Nanbo, A., Nishikawa, J., Jinushi, M. and Yoshiyama, H. (2012). Epstein-Barr Virus (EBV)-associated gastric carcinoma. Viruses 4(12): 3420-3439. (*Equal contribution)
  2. Nanbo, A. and Takada, K. (2002). The role of Epstein-Barr virus-encoded small RNAs (EBERs) in oncogenesis. Rev Med Virol 12(5): 321-326.
  3. Nanbo, A. and Takada, K. (2002). EBV and oncogenesis. Tissue Cult. Engin. 28(1): 44-47.
  4. Nanbo, A. and Takada, K. (2001). The role of Epstein-Barr Virus-encoded small RNAs (EBERs) confer oncogenesis. Jpn J. Cancer Clin. 47(13):1203-1210.
  5. Takada, K. and Nanbo, A. (2001). The role of EBERs in oncogenesis. Semin Cancer Biol 11(6): 461-467.


  1. Nanbo, A. (2003). EBER in The EB virus. In: Takada, K. (ed). Shindan to chiryousha, 39-46.
Protocols by Asuka Nanbo
  1. Purification and Fluorescent Labeling of Exosomes