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Giusy Tornillo

Education

Ph.D. in Biomedical Sciences and Human Oncology, Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy, 2012

Current position

Research Associate at European Cancer Stem Cell Research Institute (ECSCRI), Cardiff School of Biosciences, Cardiff, UK

Publications

  1. Tornillo, G., Defilippi, P. and Cabodi, S. (2014). Cas proteins: dodgy scaffolding in breast cancer. Breast Cancer Res 16(5): 443.   
  2. Fusella, F., Ferretti, R., Recupero, D., Rocca, S., Di Savino, A., Tornillo, G., Silengo, L., Turco, E., Cabodi, S., Provero, P., Pandolfi, P. P., Sapino, A., Tarone, G. and Brancaccio, M. (2014). Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway. J Pathol 234(2):152-63.
  3. Saoncella, S., Tassone, B., Deklic, E., Avolio, F., Jon, C., Tornillo, G., De Luca, E., Di Iorio, E., Piva, R., Cabodi, S., Turco, E., Paolo Pandolfi, P. and Calautti, E. (2014). Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway. Stem Cells 32(3): 754-769.
  4. Pincini, A.*, Tornillo, G.*, Orso, F., Sciortino, M., Bisaro, B., Leal Mdel, P., Lembo, A., Brizzi, M. F., Turco, E., De Pitta, C., Provero, P., Medico, E., Defilippi, P., Taverna, D. and Cabodi, S. (2013). Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells. Cell Cycle 12(15): 2409-2422. (*Joint first authors)
  5. Tornillo, G., Elia, A. R., Castellano, I., Spadaro, M., Bernabei, P., Bisaro, B., Camacho-Leal Mdel, P., Pincini, A., Provero, P., Sapino, A., Turco, E., Defilippi, P. and Cabodi, S. (2013). p130Cas alters the differentiation potential of mammary luminal progenitors by deregulating c-Kit activity. Stem Cells 31(7): 1422-1433.
  6. Bisaro, B., Montani, M., Konstantinidou, G., Marchini, C., Pietrella, L., Iezzi, M., Galie, M., Orso, F., Camporeale, A., Colombo, S. M., Di Stefano, P., Tornillo, G., Camacho-Leal, M. P., Turco, E., Taverna, D., Cabodi, S., Amici, A. and Defilippi, P. (2012). p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells. Breast Cancer Res 14(5): R137.
  7. Camacho Leal Mdel, P., Pincini, A., Tornillo, G., Fiorito, E., Bisaro, B., Di Luca, E., Turco, E., Defilippi, P. and Cabodi, S. (2012). p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF. PLoS One 7(12): e49817.
  8. D'Agostino, M., Tornillo, G., Caporaso, M. G., Barone, M. V., Ghigo, E., Bonatti, S. and Mottola, G. (2011). Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8alpha and promote its ubiquitylation and endocytosis. J Cell Sci 124(Pt 21): 3545-3556.
  9. Di Stefano, P., Leal, M. P., Tornillo, G., Bisaro, B., Repetto, D., Pincini, A., Santopietro, E., Sharma, N., Turco, E., Cabodi, S. and Defilippi, P. (2011). The adaptor proteins p140CAP and p130CAS as molecular hubs in cell migration and invasion of cancer cells. Am J Cancer Res 1(5): 663-673.
  10. Tornillo, G., Bisaro, B., Camacho-Leal Mdel, P., Galie, M., Provero, P., Di Stefano, P., Turco, E., Defilippi, P. and Cabodi, S. (2011). p130Cas promotes invasiveness of three-dimensional ErbB2-transformed mammary acinar structures by enhanced activation of mTOR/p70S6K and Rac1. Eur J Cell Biol 90(2-3): 237-248.
  11. Di Stefano, P., Leal, M. P., Tornillo, G., Bisaro, B., Repetto, D., Pincini, A., Santopietro, E., Sharma, N., Turco, E., Cabodi, S. and Defilippi, P. (2011). The adaptor proteins p140CAP and p130CAS as molecular hubs in cell migration and invasion of cancer cells. Am J Cancer Res 1(5): 663-673.
  12. Cabodi, S.*, Tinnirello, A.*, Bisaro, B.*, Tornillo, G., del Pilar Camacho-Leal, M., Forni, G., Cojoca, R., Iezzi, M., Amici, A., Montani, M., Eva, A., Di Stefano, P., Muthuswamy, S. K., Tarone, G., Turco, E. and Defilippi, P. (2010). p130Cas is an essential transducer element in ErbB2 transformation. FASEB J 24(10): 3796-3808. (*Joint first authors)
  13. Cabodi, S., Di Stefano, P., Leal Mdel, P., Tinnirello, A., Bisaro, B., Morello, V., Damiano, L., Aramu, S., Repetto, D., Tornillo, G. and Defilippi, P. (2010). Integrins and signal transduction. Adv Exp Med Biol 674: 43-54.
Protocols by Giusy Tornillo
  1. 3D Mammary Colony-Forming Cell Assay