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Heli Uronen-Hansson

Education

Ph.D. in Immunobiology, Institute of Child Health, University College London, United Kingdom

Current position

Research scientist, Section of Immunology, Lund University, Sweden

Publications

  1. Thiesen, S., Janciauskiene, S., Uronen-Hansson, H., Agace, W., Hogerkorp, C. M., Spee, P., Hakansson, K. and Grip, O. (2014). CD14hiHLA-DRdim macrophages, with a resemblance to classical blood monocytes, dominate inflamed mucosa in Crohn's disease. J Leukoc Biol 95(3): 531-541.
  2. Persson, E. K., Uronen-Hansson, H., Semmrich, M., Rivollier, A., Hagerbrand, K., Marsal, J., Gudjonsson, S., Hakansson, U., Reizis, B., Kotarsky, K. and Agace, W. W. (2013). IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation. Immunity 38(5): 958-969.
  3. Bain, C. C., Scott, C. L., Uronen-Hansson, H., Gudjonsson, S., Jansson, O., Grip, O., Guilliams, M., Malissen, B., Agace, W. W. and Mowat, A. M. (2013). Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors. Mucosal Immunol 6(3): 498-510.
  4. Poulin, L. F., Reyal, Y., Uronen-Hansson, H., Schraml, B. U., Sancho, D., Murphy, K. M., Hakansson, U. K., Moita, L. F., Agace, W. W., Bonnet, D. and Reis e Sousa, C. (2012). DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues. Blood 119(25): 6052-6062.
  5. Semmrich, M., Plantinga, M., Svensson-Frej, M., Uronen-Hansson, H., Gustafsson, T., Mowat, A. M., Yrlid, U., Lambrecht, B. N. and Agace, W. W. (2012). Directed antigen targeting in vivo identifies a role for CD103+ dendritic cells in both tolerogenic and immunogenic T-cell responses. Mucosal Immunol 5(2): 150-160.
  6. Jaensson, E., Uronen-Hansson, H., Pabst, O., Eksteen, B., Tian, J., Coombes, J. L., Berg, P. L., Davidsson, T., Powrie, F., Johansson-Lindbom, B. and Agace, W. W. (2008). Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med 205(9): 2139-2149.
  7. Steeghs, L., Keestra, A. M., van Mourik, A., Uronen-Hansson, H., van der Ley, P., Callard, R., Klein, N. and van Putten, J. P. (2008). Differential activation of human and mouse Toll-like receptor 4 by the adjuvant candidate LpxL1 of Neisseria meningitidis. Infect Immun 76(8): 3801-3807.
  8. Jones, H. E., Strid, J., Osman, M., Uronen-Hansson, H., Dixon, G., Klein, N., Wong, S. Y. and Callard, R. E. (2008). The role of beta2 integrins and lipopolysaccharide-binding protein in the phagocytosis of dead Neisseria meningitidis. Cell Microbiol 10(8): 1634-1645.
  9. Svensson, M., Marsal, J., Uronen-Hansson, H., Cheng, M., Jenkinson, W., Cilio, C., Jacobsen, S. E., Sitnicka, E., Anderson, G. and Agace, W. W. (2008). Involvement of CCR9 at multiple stages of adult T lymphopoiesis. J Leukoc Biol 83(1): 156-164.
  10. Jones, H. E., Uronen-Hansson, H., Callard, R. E., Klein, N. and Dixon, G. L. (2007). The differential response of human dendritic cells to live and killed Neisseria meningitidis. Cell Microbiol 9(12): 2856-2869.
  11. Steeghs, L., van Vliet, S. J., Uronen-Hansson, H., van Mourik, A., Engering, A., Sanchez-Hernandez, M., Klein, N., Callard, R., van Putten, J. P., van der Ley, P., van Kooyk, Y. and van de Winkel, J. G. (2006). Neisseria meningitidis expressing lgtB lipopolysaccharide targets DC-SIGN and modulates dendritic cell function. Cell Microbiol 8(2): 316-325.
  12. Uronen-Hansson, H., Steeghs, L., Allen, J., Dixon, G. L., Osman, M., van der Ley, P., Wong, S. Y., Callard, R. and Klein, N. (2004). Human dendritic cell activation by Neisseria meningitidis: phagocytosis depends on expression of lipooligosaccharide (LOS) by the bacteria and is required for optimal cytokine production. Cell Microbiol 6(7): 625-637.
  13. Uronen-Hansson, H., Allen, J., Osman, M., Squires, G., Klein, N. and Callard, R. E. (2004). Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria. Immunology 111(2): 173-178.
  14. Uronen-Hansson, H., Allen, M. L., Lichtarowicz-Krynska, E., Aynsley-Green, A., Cole, T. J., Hoiden-Guthenberg, I., Fryklund, L. and Klein, N. (2003). Growth hormone enhances proinflammatory cytokine production by monocytes in whole blood. Growth Horm IGF Res 13(5): 282-286.
  15. Cruccetti, A., Pierro, A., Uronen, H. and Klein, N. (2003). Surgical infants on total parenteral nutrition have impaired cytokine responses to microbial challenge. Journal of pediatric surgery 38(1): 138-142.
  16. Uronen, H., Williams, A. J., Dixon, G., Andersen, S. R., Van Der Ley, P., Van Deuren, M., Callard, R. E. and Klein, N. (2000). Gram-negative bacteria induce proinflammatory cytokine production by monocytes in the absence of lipopolysaccharide (LPS). Clin Exp Immunol 122(3): 312-315.
  17. Uronen, H. and Callard, R. E. (2000). Absence of CD40-CD40 ligand interactions in X-linked hyper-IgM syndrome does not affect differentiation of T helper cell subsets. Clin Exp Immunol 121(2): 346-352.
Protocols by Heli Uronen-Hansson
  1. Isolation of Cells from Human Intestinal Tissue