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Diana   Panayotova-Dimitrova

Diana Panayotova-Dimitrova


Ph.D., University of Veterinary Medicine Hannover, Germany, 2005

Current position

Postdoctoral fellow, Section Experimental Dermatology, Department of Dermatology, Venerology and Allergology, Medical Faculty of Mannheim of the University of Heidelberg, Germany


First author papers

  1. Panayotova-Dimitrova, D., Feoktistova, M., Ploesser, M., Kellert, B., Hupe, M., Horn, S., Makarov, R., Jensen, F., Porubsky, S., Schmieder, A., Zenclussen, A. C., Marx, A., Kerstan, A., Geserick, P., He, Y. W. and Leverkus, M. (2013). cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis. Cell Rep 5(2): 397-408.
  2. Stankov, M. V., Panayotova-Dimitrova, D., Leverkus, M., Schmidt, R. E. and Behrens, G. M. (2013). Thymidine analogues suppress autophagy and adipogenesis in cultured adipocytes. Antimicrob Agents Chemother 57(1): 543-551.
  3. Stankov, M. V., Panayotova-Dimitrova, D., Leverkus, M., Vondran, F. W., Bauerfeind, R., Binz, A. and Behrens, G. M. (2012). Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation. AIDS 26(16): 1995-2006


  1. Stankov, M. V., El Khatib, M., Kumar Thakur, B., Heitmann, K., Panayotova-Dimitrova, D., Schoening, J., Bourquin, J. P., Schweitzer, N., Leverkus, M., Welte, K., Reinhardt, D., Li, Z., Orkin, S. H., Behrens, G. M. and Klusmann, J. H. (2014). Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy. Leukemia 28(3): 577-588.
  2. Kliese, N., Gobrecht, P., Pachow, D., Andrae, N., Wilisch-Neumann, A., Kirches, E., Riek-Burchardt, M., Angenstein, F., Reifenberger, G., Riemenschneider, M. J., Meese, E., Panayotova-Dimitrova, D., Gutmann, D. H. and Mawrin, C. (2013). miRNA-145 is downregulated in atypical and anaplastic meningiomas and negatively regulates motility and proliferation of meningioma cells. Oncogene 32(39): 4712-4720.
  3. Feoktistova, M., Geserick, P., Panayotova-Dimitrova, D. and Leverkus, M. (2012). Pick your poison: the Ripoptosome, a cell death platform regulating apoptosis and necroptosis. Cell Cycle 11(3): 460-467.
  4. Feoktistova, M., Geserick, P., Kellert, B., Dimitrova, D. P., Langlais, C., Hupe, M., Cain, K., MacFarlane, M., Hacker, G. and Leverkus, M. (2011). cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 43(3): 449-463.
  5. Kavuri, S. M., Geserick, P., Berg, D., Dimitrova, D. P., Feoktistova, M., Siegmund, D., Gollnick, H., Neumann, M., Wajant, H. and Leverkus, M. (2011). Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex. J Biol Chem 286(19): 16631-16646.
Protocols by Diana Panayotova-Dimitrova
  1. Fluorescence Microscopy Analysis of Drug Effect on Autophagosome Formation
  2. Flow Cytometric Analysis of Autophagic Activity with Cyto-ID Staining in Primary Cells
  3. Flow Cytometric Analyses of Autophagic Activity using LC3-GFP fluorescence