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Modesto  Redrejo-Rodríguez

Modesto Redrejo-Rodríguez


Ph.D. in Molecular Biology, Madrid Autonomous University, Spain, 2009

Current position

Research Associate (ComFuturo program for Young Researchers, CSIC Foundation) at Severo Ochoa Molecular Biology Center, CSIC, Madrid, Spain


  1. Salas, M., Holguera, I., Redrejo-Rodriguez, M. and de Vega, M. (2016). DNA-Binding Proteins Essential for Protein-Primed Bacteriophage Phi29 DNA Replication. Front Mol Biosci 3: 37.
  2. Berjon-Otero, M., Villar, L., Salas, M. and Redrejo-Rodriguez, M. (2016). Disclosing early steps of protein-primed genome replication of the Gram-positive tectivirus Bam35. Nucleic Acids Res. [Epub ahead of print]
  3. Redrejo-Rodriguez, M., Vigouroux, A., Mursalimov, A., Grin, I., Alili, D., Koshenov, Z., Akishev, Z., Maksimenko, A., Bissenbaev, A. K., Matkarimov, B. T., Saparbaev, M., Ishchenko, A. A. and Morera, S. (2016). Structural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNA. Biochimie 128-129: 20-33.
  4. Berjon-Otero, M., Villar, L., de Vega, M., Salas, M. and Redrejo-Rodriguez, M. (2015). DNA polymerase from temperate phage Bam35 is endowed with processive polymerization and abasic sites translesion synthesis capacity. Proc Natl Acad Sci U S A 112(27): E3476-3484.
  5. Mursalimov, A. Saparbaev, M. K., Redrejo-Rodriguez, M., Koshenov, Z., Zhakupova, K., Ishchenko, A. A. and Matkarimov, B. (2014). Genetic dissection of the biochemical activities of human DNA repair protein, APE1. NU RESEARCH WEEK - II, At 55.
  6. Redrejo-Rodriguez, M. and Salas, M. (2014). Multiple roles of genome-attached bacteriophage terminal proteins. Virology 468-470: 322-329.
  7. Redrejo-Rodríguez, M. and Salas, M. L. (2014). Repair of base damage and genome maintenance in the nucleo-cytoplasmic large DNA viruses. Virus Res 179: 12-25.
  8. Holguera, I., Redrejo-Rodríguez, M., Salas, M. and Muñoz-Espín, D. (2014). New insights in the varphi29 terminal protein DNA-binding and host nucleoid localization functions. Mol Microbiol 91(2): 232-241.
  9. Redrejo-Rodríguez, M., Muñoz-Espín, D., Holguera, I., Mencía, M. and Salas, M. (2013). Nuclear and nucleoid localization are independently conserved functions in bacteriophage terminal proteins. Mol Microbiol 90(4): 858-868.
  10. Redrejo-Rodríguez, M., Rodríguez, J. M., Suárez, C., Salas, J. and Salas, M. L. (2013). Involvement of the reparative DNA polymerase Pol X of African swine fever virus in the maintenance of viral genome stability in vivo. J Virol 87(17): 9780-9787.
  11. Redrejo-Rodriguez, M., Munoz-Espin, D., Holguera, I., Mencia, M. and Salas, M. (2013). Nuclear localization signals in phage terminal proteins provide a novel gene delivery tool in mammalian cells. Commun Integr Biol 6(2): e22829.
  12. Redrejo-Rodríguez, M., Muñoz-Espín, D., Holguera, I., Mencía, M. and Salas, M. (2012). Functional eukaryotic nuclear localization signals are widespread in terminal proteins of bacteriophages. Proc Natl Acad Sci U S A 109(45): 18482-18487.
  13. Redrejo-Rodríguez, M., Rodríguez, J. M., Salas, J. and Salas, M. L. (2011). Repair of Viral Genomes by Base Excision Pathways: African Swine Fever Virus as a Paradigm. In: Storici, F. (Ed). DNA Repair - On the Pathways to Fixing DNA Damage and Errors.
  14. Redrejo-Rodríguez, M., Saint-Pierre, C., Couve, S., Mazouzi, A., Ishchenko, A. A., Gasparutto, D. and Saparbaev, M. (2011). New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways. PLoS One 6(7): e21039.
  15. Gelin, A., Redrejo-Rodríguez, M., Laval, J., Fedorova, O. S., Saparbaev, M. and Ishchenko, A. A. (2010). Genetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activity. PLoS One 5(8): e12241.
  16. Redrejo-Rodríguez, M., Ishchenko, A. A., Saparbaev, M. K., Salas, M. L. and Salas, J. (2009). African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA. Virology 390(1): 102-109.
  17. Rodríguez, I., Nogal, M. L., Redrejo-Rodríguez, M., Bustos, M. J. and Salas, M. L. (2009). The African swine fever virus virion membrane protein pE248R is required for virus infectivity and an early postentry event. J Virol 83(23): 12290-12300.
  18. Redrejo-Rodríguez, M., García-Escudero, R., Yáñez-Muñoz, R. J., Salas, M. L. and Salas, J. (2006). African swine fever virus protein pE296R is a DNA repair apurinic/apyrimidinic endonuclease required for virus growth in swine macrophages. J Virol 80(10): 4847-4857.
  19. Rodríguez, I., Redrejo-Rodríguez, M., Rodríguez, J. M., Alejo, A., Salas, J. and Salas, M. L. (2006). African swine fever virus pB119L protein is a flavin adenine dinucleotide-linked sulfhydryl oxidase. J Virol 80(7): 3157-3166.
  20. Redrejo-Rodríguez, M., Tejeda-Cano, A., del Carmen Pinto, M. and Macı́as, P. (2004). Lipoxygenase inhibition by flavonoids: semiempirical study of the structure–activity relation. Journal of Molecular Structure: THEOCHEM 674(1): 121-124.
Protocols by Modesto Redrejo-Rodríguez
  1. Determination of Mutation Frequency During Viral DNA Replication