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Kiyoshi Takeda

Education

M.D., Medical School, Osaka University, 1992
Ph.D., Graduate School of Medicine, Osaka University, 1998

Current position

Professor, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University (2007-present)
Professor, Laboratory of Mucosal Immunology, WPI Immunology Frontier Research Center, Osaka University (2007-present)
Coordinator, Interdisciplinary Program for Biomedical Sciences, Institute of Academic Initiatives, Osaka University (2012-present)

Publications

Original research papers (since 2008)

  1. Yokota, K., Sato, K., Miyazaki, T., Kitaura, H., Kayama, H., Miyoshi, F., Araki, Y., Akiyama, Y., Takeda, K. and Mimura, T. (2014). Combination of tumor necrosis factor alpha and interleukin-6 induces mouse osteoclast-like cells with bone resorption activity both in vitro and in vivo. Arthritis Rheumatol 66(1): 121-129.
  2. Shimada, Y., Kinoshita, M., Harada, K., Mizutani, M., Masahata, K., Kayama, H. and Takeda, K. (2013). Commensal bacteria-dependent indole production enhances epithelial barrier function in the colon. PLoS One 8(11): e80604.
  3. Ogino, T., Nishimura, J., Barman, S., Kayama, H., Uematsu, S., Okuzaki, D., Osawa, H., Haraguchi, N., Uemura, M., Hata, T., Takemasa, I., Mizushima, T., Yamamoto, H., Takeda, K., Doki, Y. and Mori, M. (2013). Increased Th17-inducing activity of CD14+ CD163 low myeloid cells in intestinal lamina propria of patients with Crohn's disease. Gastroenterology 145(6): 1380-1391 e1381.
  4. Kimura, T., Katoh, H., Kayama, H., Saiga, H., Okuyama, M., Okamoto, T., Umemoto, E., Matsuura, Y., Yamamoto, M. and Takeda, K. (2013). Ifit1 inhibits Japanese encephalitis virus replication through binding to 5' capped 2'-O unmethylated RNA. J Virol 87(18): 9997-10003.
  5. Ishii, H., Tanabe, S., Ueno, M., Kubo, T., Kayama, H., Serada, S., Fujimoto, M., Takeda, K., Naka, T. and Yamashita, T. (2013). ifn-gamma-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury. Cell Death Dis 4: e710.
  6. Kunisawa, J., Gohda, M., Hashimoto, E., Ishikawa, I., Higuchi, M., Suzuki, Y., Goto, Y., Panea, C., Ivanov, II, Sumiya, R., Aayam, L., Wake, T., Tajiri, S., Kurashima, Y., Shikata, S., Akira, S., Takeda, K. and Kiyono, H. (2013). Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice. Nat Commun 4: 1772.
  7. Kamiyama, N., Yamamoto, M., Saiga, H., Ma, J. S., Ohshima, J., Machimura, S., Sasai, M., Kimura, T., Ueda, Y., Kayama, H. and Takeda, K. (2013). CREBH determines the severity of sulpyrine-induced fatal shock. PLoS One 8(2): e55800.
  8. Kusu, T., Kayama, H., Kinoshita, M., Jeon, S. G., Ueda, Y., Goto, Y., Okumura, R., Saiga, H., Kurakawa, T., Ikeda, K., Maeda, Y., Nishimura, J., Arima, Y., Atarashi, K., Honda, K., Murakami, M., Kunisawa, J., Kiyono, H., Okumura, M., Yamamoto, M. and Takeda, K. (2013). Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. J Immunol 190(2): 774-783.
  9. Shigekawa, M., Hikita, H., Kodama, T., Shimizu, S., Li, W., Uemura, A., Miyagi, T., Hosui, A., Kanto, T., Hiramatsu, N., Tatsumi, T., Takeda, K., Akira, S. and Takehara, T. (2012). Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction. Am J Pathol 181(6): 2105-2113.
  10. Saiga, H., Kitada, S., Shimada, Y., Kamiyama, N., Okuyama, M., Makino, M., Yamamoto, M. and Takeda, K. (2012). Critical role of AIM2 in Mycobacterium tuberculosis infection. Int Immunol 24(10): 637-644.
  11. Kinoshita, M., Kayama, H., Kusu, T., Yamaguchi, T., Kunisawa, J., Kiyono, H., Sakaguchi, S. and Takeda, K. (2012). Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. J Immunol 189(6): 2869-2878.
  12. Yamamoto, M., Okuyama, M., Ma, J. S., Kimura, T., Kamiyama, N., Saiga, H., Ohshima, J., Sasai, M., Kayama, H., Okamoto, T., Huang, D. C., Soldati-Favre, D., Horie, K., Takeda, J. and Takeda, K. (2012). A cluster of interferon-gamma-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii. Immunity 37(2): 302-313.
  13. Jeon, S. G., Kayama, H., Ueda, Y., Takahashi, T., Asahara, T., Tsuji, H., Tsuji, N. M., Kiyono, H., Ma, J. S., Kusu, T., Okumura, R., Hara, H., Yoshida, H., Yamamoto, M., Nomoto, K. and Takeda, K. (2012). Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog 8(5): e1002714.
  14. Tsujino, K., Takeda, Y., Arai, T., Shintani, Y., Inagaki, R., Saiga, H., Iwasaki, T., Tetsumoto, S., Jin, Y., Ihara, S., Minami, T., Suzuki, M., Nagatomo, I., Inoue, K., Kida, H., Kijima, T., Ito, M., Kitaichi, M., Inoue, Y., Tachibana, I., Takeda, K., Okumura, M., Hemler, M. E. and Kumanogoh, A. (2012). Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity. Am J Respir Crit Care Med 186(2): 170-180.
  15. Kayama, H., Ueda, Y., Sawa, Y., Jeon, S. G., Ma, J. S., Okumura, R., Kubo, A., Ishii, M., Okazaki, T., Murakami, M., Yamamoto, M., Yagita, H. and Takeda, K. (2012). Intestinal CX3C chemokine receptor 1(high) (CX3CR1(high)) myeloid cells prevent T-cell-dependent colitis. Proc Natl Acad Sci U S A 109(13): 5010-5015.
  16. Niida, T., Isoda, K., Kitagaki, M., Ishigami, N., Adachi, T., Matsubara, O., Takeda, K., Kishimoto, T. and Ohsuzu, F. (2012). IkappaBNS regulates interleukin-6 production and inhibits neointimal formation after vascular injury in mice. Cardiovasc Res 93(2): 371-379.
  17. Takata, K., Kinoshita, M., Okuno, T., Moriya, M., Kohda, T., Honorat, J. A., Sugimoto, T., Kumanogoh, A., Kayama, H., Takeda, K., Sakoda, S. and Nakatsuji, Y. (2011). The lactic acid bacterium Pediococcus acidilactici suppresses autoimmune encephalomyelitis by inducing IL-10-producing regulatory T cells. PLoS One 6(11): e27644.
  18. Matsuda, A., Ogawa, M., Yanai, H., Naka, D., Goto, A., Ao, T., Tanno, Y., Takeda, K., Watanabe, Y., Honda, K. and Taniguchi, T. (2011). Generation of mice deficient in RNA-binding motif protein 3 (RBM3) and characterization of its role in innate immune responses and cell growth. Biochem Biophys Res Commun 411(1): 7-13.
  19. Yamamoto, M., Ma, J. S., Mueller, C., Kamiyama, N., Saiga, H., Kubo, E., Kimura, T., Okamoto, T., Okuyama, M., Kayama, H., Nagamune, K., Takashima, S., Matsuura, Y., Soldati-Favre, D. and Takeda, K. (2011). ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18. J Exp Med 208(7): 1533-1546.
  20. Iwata-Kajihara, T., Sumimoto, H., Kawamura, N., Ueda, R., Takahashi, T., Mizuguchi, H., Miyagishi, M., Takeda, K. and Kawakami, Y. (2011). Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors. J Immunol 187(1): 27-36.
  21. Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., Taniguchi, T., Takeda, K., Hori, S., Ivanov, II, Umesaki, Y., Itoh, K. and Honda, K. (2011). Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331(6015): 337-341.
  22. Ueda, Y., Kayama, H., Jeon, S. G., Kusu, T., Isaka, Y., Rakugi, H., Yamamoto, M. and Takeda, K. (2010). Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10. Int Immunol 22(12): 953-962.
  23. Xiao, G., Miyazato, A., Abe, Y., Zhang, T., Nakamura, K., Inden, K., Tanaka, M., Tanno, D., Miyasaka, T., Ishii, K., Takeda, K., Akira, S., Saijo, S., Iwakura, Y., Adachi, Y., Ohno, N., Yamamoto, N., Kunishima, H., Hirakata, Y., Kaku, M. and Kawakami, K. (2010). Activation of myeloid dendritic cells by deoxynucleic acids from Cordyceps sinensis via a Toll-like receptor 9-dependent pathway. Cell Immunol 263(2): 241-250.
  24. Okuyama, M., Kayama, H., Atarashi, K., Saiga, H., Kimura, T., Waisman, A., Yamamoto, M. and Takeda, K. (2010). A novel in vivo inducible dendritic cell ablation model in mice. Biochem Biophys Res Commun 397(3): 559-563.
  25. Obana, M., Maeda, M., Takeda, K., Hayama, A., Mohri, T., Yamashita, T., Nakaoka, Y., Komuro, I., Takeda, K., Matsumiya, G., Azuma, J. and Fujio, Y. (2010). Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction. Circulation 121(5): 684-691.
  26. Yamamoto, M., Standley, D. M., Takashima, S., Saiga, H., Okuyama, M., Kayama, H., Kubo, E., Ito, H., Takaura, M., Matsuda, T., Soldati-Favre, D. and Takeda, K. (2009). A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3. J Exp Med 206(12): 2747-2760.
  27. Ivanov, II, Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., Tanoue, T., Imaoka, A., Itoh, K., Takeda, K., Umesaki, Y., Honda, K. and Littman, D. R. (2009). Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139(3): 485-498.
  28. Pejnovic, N., Vratimos, A., Lee, S. H., Popadic, D., Takeda, K., Akira, S. and Chan, W. L. (2009). Increased atherosclerotic lesions and Th17 in interleukin-18 deficient apolipoprotein E-knockout mice fed high-fat diet. Mol Immunol 47(1): 37-45.
  29. Miyazato, A., Nakamura, K., Yamamoto, N., Mora-Montes, H. M., Tanaka, M., Abe, Y., Tanno, D., Inden, K., Gang, X., Ishii, K., Takeda, K., Akira, S., Saijo, S., Iwakura, Y., Adachi, Y., Ohno, N., Mitsutake, K., Gow, N. A., Kaku, M. and Kawakami, K. (2009). Toll-like receptor 9-dependent activation of myeloid dendritic cells by Deoxynucleic acids from Candida albicans. Infect Immun 77(7): 3056-3064.
  30. Kayama, H., Koga, R., Atarashi, K., Okuyama, M., Kimura, T., Mak, T. W., Uematsu, S., Akira, S., Takayanagi, H., Honda, K., Yamamoto, M. and Takeda, K. (2009). NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection. PLoS Pathog 5(7): e1000514.
  31. Yamasaki, S., Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Tateno, H., Uno, J., Hirabayashi, J., Mikami, Y., Takeda, K., Akira, S. and Saito, T. (2009). C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc Natl Acad Sci U S A 106(6): 1897-1902.
  32. Morishita, H., Saito, F., Kayama, H., Atarashi, K., Kuwata, H., Yamamoto, M. and Takeda, K. (2009). Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses. Int Immunol 21(4): 457-465.
  33. Haga, S., Ozaki, M., Inoue, H., Okamoto, Y., Ogawa, W., Takeda, K., Akira, S. and Todo, S. (2009). The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation. Hepatology 49(1): 204-214.
  34. Saiga, H., Nishimura, J., Kuwata, H., Okuyama, M., Matsumoto, S., Sato, S., Matsumoto, M., Akira, S., Yoshikai, Y., Honda, K., Yamamoto, M. and Takeda, K. (2008). Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium. J Immunol 181(12): 8521-8527.
  35. Nakamura, K., Miyazato, A., Koguchi, Y., Adachi, Y., Ohno, N., Saijo, S., Iwakura, Y., Takeda, K., Akira, S., Fujita, J., Ishii, K., Kaku, M. and Kawakami, K. (2008). Toll-like receptor 2 (TLR2) and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei. Microbes Infect 10(10-11): 1223-1227.
  36. Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., Onoue, M., Yagita, H., Ishii, N., Evans, R., Honda, K. and Takeda, K. (2008). ATP drives lamina propria T(H)17 cell differentiation. Nature 455(7214): 808-812.
  37. Nakamura, J., Fujimoto, M., Yasuda, K., Takeda, K., Akira, S., Hatayama, T., Takagi, Y., Nozaki, K., Hosokawa, N. and Nagata, K. (2008). Targeted disruption of Hsp110/105 gene protects against ischemic stress. Stroke 39(10): 2853-2859.
  38. Saito, F., Kuwata, H., Oiki, E., Koike, M., Uchiyama, Y., Honda, K. and Takeda, K. (2008). Inefficient phagosome maturation in infant macrophages. Biochem Biophys Res Commun 375(1): 113-118.
  39. Herrmann, J. E., Imura, T., Song, B., Qi, J., Ao, Y., Nguyen, T. K., Korsak, R. A., Takeda, K., Akira, S. and Sofroniew, M. V. (2008). STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J Neurosci 28(28): 7231-7243.
  40. Gong, L., Yao, F., Hockman, K., Heng, H. H., Morton, G. J., Takeda, K., Akira, S., Low, M. J., Rubinstein, M. and MacKenzie, R. G. (2008). Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis. Endocrinology 149(7): 3346-3354.
  41. Ueta, M., Hamuro, J., Ueda, E., Katoh, N., Yamamoto, M., Takeda, K., Akira, S. and Kinoshita, S. (2008). Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IkappaBzeta-/- mice. Invest Ophthalmol Vis Sci 49(8): 3387-3394.
  42. Kayama, H., Ramirez-Carrozzi, V. R., Yamamoto, M., Mizutani, T., Kuwata, H., Iba, H., Matsumoto, M., Honda, K., Smale, S. T. and Takeda, K. (2008). Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IkappaBzeta. J Biol Chem 283(18): 12468-12477.
  43. Nakamura, K., Miyazato, A., Xiao, G., Hatta, M., Inden, K., Aoyagi, T., Shiratori, K., Takeda, K., Akira, S., Saijo, S., Iwakura, Y., Adachi, Y., Ohno, N., Suzuki, K., Fujita, J., Kaku, M. and Kawakami, K. (2008). Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway. J Immunol 180(6): 4067-4074.
  44. Nishimura, J., Saiga, H., Sato, S., Okuyama, M., Kayama, H., Kuwata, H., Matsumoto, S., Nishida, T., Sawa, Y., Akira, S., Yoshikai, Y., Yamamoto, M. and Takeda, K. (2008). Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor. J Immunol 180(6): 4032-4039.
  45. Hisaeda, H., Tetsutani, K., Imai, T., Moriya, C., Tu, L., Hamano, S., Duan, X., Chou, B., Ishida, H., Aramaki, A., Shen, J., Ishii, K. J., Coban, C., Akira, S., Takeda, K., Yasutomo, K., Torii, M. and Himeno, K. (2008). Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells. J Immunol 180(4): 2496-2503.
  46. Owaki, T., Asakawa, M., Morishima, N., Mizoguchi, I., Fukai, F., Takeda, K., Mizuguchi, J. and Yoshimoto, T. (2008). STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production. J Immunol 180(5): 2903-2911

Review papers

  1. Kayama, H., Nishimura, J. and Takeda, K. (2013). Regulation of Intestinal Homeostasis by Innate Immune Cells. Immune Netw 13(6): 227-234.
  2. Kayama, H., Jeon, S. G., and Takeda, K. (2013). Probiotics and innate immunity: Implication in chronic disease prevention. Probiotics in Prevention of Life Style Disorders
  3. Kayama, H. and Takeda, K. (2012). Regulation of intestinal homeostasis by innate and adaptive immunity. Int Immunol 24(11): 673-680.
  4. Kurosaki, T., Saito, T., Kumanogoh, A., Takeda, K. and Kaisho, T. (2012). Dynamism of immune reactions and regulation. Int Immunol 24(8): 473-475.
  5. Vandenbon, A., Teraguchi, S., Akira, S., Takeda, K. and Standley, D. M. (2012). Systems biology approaches to toll-like receptor signaling. Wiley Interdiscip Rev Syst Biol Med 4(5): 497-507.
  6. Yamamoto, M. and Takeda, K. (2012). Inhibition of ATF6beta-dependent host adaptive immune response by a Toxoplasma virulence factor ROP18. Virulence 3(1): 77-80.
  7. Yamamoto, M. and Takeda, K. (2012). A method for the generation of conditional gene-targeted mice. Methods Mol Biol 757: 399-410.
  8. Saiga, H., Shimada, Y. and Takeda, K. (2011). Innate immune effectors in mycobacterial infection. Clin Dev Immunol 2011: 347594.
  9. Yamamoto, M. and Takeda, K. (2010). Current views of toll-like receptor signaling pathways. Gastroenterol Res Pract 2010: 240365.
  10. Hedayat, M., Takeda, K. and Rezaei, N. (2012). Prophylactic and therapeutic implications of toll-like receptor ligands. Med Res Rev 32(2): 294-325.
  11. Kayama, H. and Takeda, K. (2010). The innate immune response to Trypanosoma cruzi infection. Microbes Infect 12(7): 511-517.
  12. Takeda, K. (2009). The lipid A receptor. Adv Exp Med Biol 667: 53-58.
  13. Kaisho, T. and Takeda, K. (2009). The study of innate immunity in Japan: a historical perspective. Int Immunol 21(4): 313-316.
  14. Atarashi, K., Takeda, K., and Honda, K. (2009). Mechanism of Th17 cell differentiation in the intestinal lamina propria. Inflamm. Regeneration 29, 263-269.
  15. Honda, K. and Takeda, K. (2009). Regulatory mechanisms of immune responses to intestinal bacteria. Mucosal Immunol 2(3): 187-196.
  16. Yamamoto, M., and Takeda, K. (2008). Regulation of host immune responses by nuclear IkB proteins. Inflamm. Regeneration. 28, 516-521.
  17. Yamamoto, M. and Takeda, K. (2008). Role of nuclear IkappaB proteins in the regulation of host immune responses. J Infect Chemother 14(4): 265-269.
  18. Takeda, K., Yamamoto, M. and Honda, K. (2008). Assessing the response of cells to TLR stimulation. Signaling by Toll-like receptors 1-21.
  19. Takeda, K. and Akira, S. (2007). Toll-like receptors. Curr Protoc Immunol Chapter 14: Unit 14 12.
  20. Takeda, K., Hemmi, H. and Akira, S. (2006). Mechanism for recognition of CpG DNA. Vaccine Adjuvants, Springer: 69-86.
  21. Takeda, K. (2005). Evolution and integration of innate immune recognition systems: the Toll-like receptors. J Endotoxin Res 11(1): 51-55.
  22. Takeda, K. and Akira, S. (2005). Toll-like receptors in innate immunity. Int Immunol 17(1): 1-14.
  23. Takeda, K. and Akira, S. (2005). Toll-like receptors in innate immunity. International immunology 17(1): 1-14.
  24. Akira, S. and Takeda, K. (2004). Functions of toll-like receptors: lessons from KO mice. C R Biol 327(6): 581-589.
  25. Takeda, K. and Akira, S. (2004). Biological roles of the STAT family in cytokine signaling. Transcription Factors, Springer: 97-121.
  26. Akira, S. and Takeda, K. (2004). Toll-like receptor signalling. Nat Rev Immunol 4(7): 499-511.
  27. Takeda, K. and Akira, S. (2004). Microbial recognition by Toll-like receptors. J Dermatol Sci 34(2): 73-82.
  28. Takeda, K. and Akira, S. (2004). TLR signaling pathways. Semin Immunol 16(1): 3-9.
  29. Yamamoto, M., Takeda, K. and Akira, S. (2004). TIR domain-containing adaptors define the specificity of TLR signaling. Mol Immunol 40(12): 861-868.
  30. Takeda, K. and Akira, S. (2003). Tissue-specific function of STAT3. Signal Transducers and Activators of Transcription (STATs), Springer: 513-523.
  31. Akira, S., Yamamoto, M. and Takeda, K. (2003). Role of adapters in Toll-like receptor signalling. Biochem Soc Trans 31(Pt 3): 637-642.
  32. Takeda, K. and Akira, S. (2003). Toll receptors and pathogen resistance. Cell Microbiol 5(3): 143-153.
  33. Takeda, K., Kaisho, T. and Akira, S. (2003). Toll-like receptors. Annu Rev Immunol 21: 335-376.
  34. Takeda, K., and Akira, S. (2003). Toll receptors. Curr. Proto. Immunol.
  35. Takeda, K., Takeuchi, O. and Akira, S. (2002). Recognition of lipopeptides by Toll-like receptors. J Endotoxin Res 8(6): 459-463.
  36. Takeda, K. and Akira, S. (2001). Regulation of innate immune responses by Toll-like receptors. Jpn J Infect Dis 54(6): 209-219.
  37. Takeda, K. and Akira, S. (2001). Multi-functional roles of Stat3 revealed by conditional gene targeting. Arch Immunol Ther Exp (Warsz) 49(4): 279-283.
  38. Takeda, K. and Akira, S. (2001). Roles of Toll-like receptors in innate immune responses. Genes Cells 6(9): 733-742.
  39. Akira, S., Takeda, K. and Kaisho, T. (2001). Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2(8): 675-680.
  40. Chapman, R. S., Lourenco, P., Tonner, E., Flint, D., Selbert, S., Takeda, K., Akira, S., Clarke, A. R. and Watson, C. J. (2000). The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3. Adv Exp Med Biol 480: 129-138.
  41. Takeda, K. and Akira, S. (2000). STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev 11(3): 199-207.
  42. Takeda, K., Kishimoto, T. and Akira, S. (1997). Signal transducer and activator of transcription protein (STAT): its relation to Th1/Th2-mediated diseases. Nutrition 13(11-12): 987-988.
  43. Takeda, K., Kishimoto, T. and Akira, S. (1997). STAT6: its role in interleukin 4-mediated biological functions. J Mol Med (Berl) 75(5): 317-326.
Protocols by Kiyoshi Takeda
  1. Cellular Translational Reporter Assay