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Janghoo Lim


Ph.D. in Developmental Neurobiology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA, 2004

Current position

Assistant Professor, Department of Genetics, Yale University, New Haven, Connecticut, USA


  1. Sakai, Y., Ohkubo, K., Matsushita, Y., Akamine, S., Ishizaki, Y., Torisu, H., Ihara, K., Sanefuji, M., Kim, M. S., Lee, K. U., Shaw, C. A., Lim, J., Nakabeppu, Y. and Hara, T. (2013). Neuroendocrine phenotypes in a boy with 5q14 deletion syndrome implicate the regulatory roles of myocyte-specific enhancer factor 2C in the postnatal hypothalamus. Eur J Med Genet 56(9): 475-483.
  2. Kim, S., Chahrour, M., Ben-Shachar, S. and Lim, J. (2013). Ube3a/E6AP is involved in a subset of MeCP2 functions. Biochem Biophys Res Commun 437(1): 67-73.
  3. Ju, H., Kokubu, H., Todd, T. W., Kahle, J. J., Kim, S., Richman, R., Chirala, K., Orr, H. T., Zoghbi, H. Y. and Lim, J. (2013). Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1. J Neurosci 33(22): 9328-9336.
  4. Kahle, J. J., Gulbahce, N., Shaw, C. A., Lim, J., Hill, D. E., Barabasi, A. L. and Zoghbi, H. Y. (2011). Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. Hum Mol Genet 20(3): 510-527.
  5. Duvick, L., Barnes, J., Ebner, B., Agrawal, S., Andresen, M., Lim, J., Giesler, G. J., Zoghbi, H. Y. and Orr, H. T. (2010). SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776. Neuron 67(6): 929-935.
  6. Lim, J., Jafar-Nejad, H., Hsu, Y. C. and Choi, K. W. (2008). Novel function of the class I bHLH protein Daughterless in the negative regulation of proneural gene expression in the Drosophila eye. EMBO Rep 9(11): 1128-1133.
  7. Lim, J., Crespo-Barreto, J., Jafar-Nejad, P., Bowman, A. B., Richman, R., Hill, D. E., Orr, H. T. and Zoghbi, H. Y. (2008). Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature 452(7188): 713-718.
  8. Al-Ramahi, I., Perez, A. M., Lim, J., Zhang, M., Sorensen, R., de Haro, M., Branco, J., Pulst, S. M., Zoghbi, H. Y. and Botas, J. (2007). dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1. PLoS Genet 3(12): e234.
  9. Lim, J., Lee, O. K., Hsu, Y. C., Singh, A. and Choi, K. W. (2007). Drosophila TRAP230/240 are essential coactivators for Atonal in retinal neurogenesis. Dev Biol 308(2): 322-330.
  10. Lam, Y. C.*, Bowman, A. B.*, Jafar-Nejad, P., Lim, J., Richman, R., Fryer, J. D., Hyun, E. D., Duvick, L. A., Orr, H. T., Botas, J. and Zoghbi, H. Y. (2006). ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology. Cell 127(7): 1335-1347. (*These authors contributed equally to this work.)
  11. Lim, J., Hao, T., Shaw, C., Patel, A. J., Szabo, G., Rual, J. F., Fisk, C. J., Li, N., Smolyar, A., Hill, D. E., Barabasi, A. L., Vidal, M. and Zoghbi, H. Y. (2006). A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell 125(4): 801-814.
  12. Rual, J. F., Venkatesan, K., Hao, T., Hirozane-Kishikawa, T., Dricot, A., Li, N., Berriz, G. F., Gibbons, F. D., Dreze, M., Ayivi-Guedehoussou, N., Klitgord, N., Simon, C., Boxem, M., Milstein, S., Rosenberg, J., Goldberg, D. S., Zhang, L. V., Wong, S. L., Franklin, G., Li, S., Albala, J. S., Lim, J., Fraughton, C., Llamosas, E., Cevik, S., Bex, C., Lamesch, P., Sikorski, R. S., Vandenhaute, J., Zoghbi, H. Y., Smolyar, A., Bosak, S., Sequerra, R., Doucette-Stamm, L., Cusick, M. E., Hill, D. E., Roth, F. P. and Vidal, M. (2005). Towards a proteome-scale map of the human protein-protein interaction network. Nature 437(7062): 1173-1178.
  13. Lim, J., Norga, K. K., Chen, Z. and Choi, K. W. (2005). Control of planar cell polarity by interaction of DWnt4 and four-jointed. Genesis 42(3): 150-161.
  14. Lim, J. and Choi, K. W. (2004). Induction and autoregulation of the anti-proneural gene Bar during retinal neurogenesis in Drosophila. Development 131(22): 5573-5580.
  15. Lim, J. and Choi, K. W. (2004). Drosophila eye disc margin is a center for organizing long-range planar polarity. Genesis 39(1): 26-37.
  16. Lim, J. and Choi, K. W. (2003). Bar homeodomain proteins are anti-proneural in the Drosophila eye: transcriptional repression of atonal by Bar prevents ectopic retinal neurogenesis. Development 130(24): 5965-5974.
  17. Jung, D. J., Sung, H. S., Goo, Y. W., Lee, H. M., Park, O. K., Jung, S. Y., Lim, J., Kim, H. J., Lee, S. K., Kim, T. S., Lee, J. W. and Lee, Y. C. (2002). Novel transcription coactivator complex containing activating signal cointegrator 1. Mol Cell Biol 22(14): 5203-5211.
Protocols by Janghoo Lim
  1. X-gal Staining on Adult Mouse Brain Sections