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Mireille H. Lahoud


PhD in Molecular Biology, Monash Institute of Reproduction and Development, Monash University, 1997

Current position

Senior Research Fellow, Centre for Immunology, Burnet Institute

Publications (since 2005)

  1. Zhang, J. G.*, Czabotar, P. E.*, Policheni, A. N., Caminschi, I., Wan, S. S., Kitsoulis, S., Tullett, K. M., Robin, A. Y., Brammananth, R., van Delft, M. F., Lu, J., O'Reilly, L. A., Josefsson, E. C., Kile, B. T., Chin, W. J., Mintern, J. D., Olshina, M. A., Wong, W., Baum, J., Wright, M. D., Huang, D. C., Mohandas, N., Coppel, R. L., Colman, P. M., Nicola, N. A., Shortman, K.# and Lahoud, M. H.# (2012). The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity 36(4): 646-657.
  2. Caminschi, I., Vremec, D., Ahmet, F., Lahoud, M. H., Villadangos, J. A., Murphy, K. M., Heath, W. R. and Shortman, K. (2012). Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3(-/-) mice. Mol Immunol 50(1-2): 9-17.
  3. O’Keeffe, M., Lahoud, M.H., Caminschi, I. and Wu, L. (2011). Dendritic Cell Subsets and Immune Regulation. In: Innate and Adaptive Immune Regulation and Cancer Immunotherapy. (Editor: R.F. Wang). DOI: 10.1007/978-1-4419-9914-6_7.
  4. Desch, A. N., Randolph, G. J., Murphy, K., Gautier, E. L., Kedl, R. M., Lahoud, M. H., Caminschi, I., Shortman, K., Henson, P. M. and Jakubzick, C. V. (2011). CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen. J Exp Med 208(9): 1789-1797.
  5. Lahoud, M. H., Ahmet, F., Kitsoulis, S., Wan, S. S., Vremec, D., Lee, C. N., Phipson, B., Shi, W., Smyth, G. K., Lew, A. M., Kato, Y., Mueller, S. N., Davey, G. M., Heath, W. R., Shortman, K. and Caminschi, I. (2011). Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype. J Immunol 187(2): 842-850.
  6. Idoyaga, J., Lubkin, A., Fiorese, C., Lahoud, M. H., Caminschi, I., Huang, Y., Rodriguez, A., Clausen, B. E., Park, C. G., Trumpfheller, C. and Steinman, R. M. (2011). Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A. Proc Natl Acad Sci U S A 108(6): 2384-2389.
  7. Prato, S., Mintern, J. D., Lahoud, M. H., Huang, D. C. and Villadangos, J. A. (2011). Induction of antigen-specific effector-phase tolerance following vaccination against a previously ignored B-cell lymphoma. Immunol Cell Biol 89(5): 595-603.
  8. van Delft, M. F., Smith, D. P., Lahoud, M. H., Huang, D. C. and Adams, J. M. (2010). Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases. Cell Death Differ 17(5): 821-832.
  9. Shortman, K., Lahoud, M. H. and Caminschi, I. (2009). Improving vaccines by targeting antigens to dendritic cells. Exp Mol Med 41(2): 61-66. .
  10. Caminschi, I., Lahoud, M. H. and Shortman, K. (2009). Enhancing immune responses by targeting antigen to DC. Eur J Immunol 39(4): 931-938.
  11. Lahoud, M. H., Proietto, A. I., Ahmet, F., Kitsoulis, S., Eidsmo, L., Wu, L., Sathe, P., Pietersz, S., Chang, H. W., Walker, I. D., Maraskovsky, E., Braley, H., Lew, A. M., Wright, M. D., Heath, W. R., Shortman, K. and Caminschi, I.# (2009). The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses. J Immunol 182(12): 7587-7594.
  12. Proietto, A. I., van Dommelen, S., Zhou, P., Rizzitelli, A., D'Amico, A., Steptoe, R. J., Naik, S. H., Lahoud, M. H., Liu, Y., Zheng, P., Shortman, K. and Wu, L. (2008). Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc Natl Acad Sci U S A 105(50): 19869-19874.
  13. Proietto, A. I., Lahoud, M. H. and Wu, L. (2008). Distinct functional capacities of mouse thymic and splenic dendritic cell populations. Immunol Cell Biol 86(8): 700-708.
  14. Caminschi, I.*#, Proietto, A. I.*, Ahmet, F., Kitsoulis, S., Shin Teh, J., Lo, J. C., Rizzitelli, A., Wu, L., Vremec, D., van Dommelen, S. L., Campbell, I. K., Maraskovsky, E., Braley, H., Davey, G. M., Mottram, P., van de Velde, N., Jensen, K., Lew, A. M., Wright, M. D., Heath, W. R., Shortman, K. and Lahoud, M. H.# (2008). The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. Blood 112(8): 3264-3273.
  15. Caminschi, I., Ahmet, F., Heger, K., Brady, J., Nutt, S. L., Vremec, D., Pietersz, S., Lahoud, M. H., Schofield, L., Hansen, D. S., O'Keeffe, M., Smyth, M. J., Bedoui, S., Davey, G. M., Villadangos, J. A., Heath, W. R. and Shortman, K. (2007). Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells. J Exp Med 204(11): 2579-2590.
  16. Vremec, D., O'Keeffe, M., Hochrein, H., Fuchsberger, M., Caminschi, I., Lahoud, M. and Shortman, K. (2007). Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells. Blood 109(3): 1165-1173.
  17. Caminschi, I., Corbett, A. J., Zahra, C., Lahoud, M., Lucas, K. M., Sofi, M., Vremec, D., Gramberg, T., Pohlmann, S., Curtis, J., Handman, E., van Dommelen, S. L., Fleming, P., Degli-Esposti, M. A., Shortman, K. and Wright, M. D. (2006). Functional comparison of mouse CIRE/mouse DC-SIGN and human DC-SIGN. Int Immunol 18(5): 741-753.
  18. Caminschi, I., Vandenabeele, S., Sofi, M., McKnight, A. J., Ward, N., Brodnicki, T. C., Toy, T., Lahoud, M., Maraskovsky, E., Shortman, K. and Wright, M. D. (2006). Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE. DNA Seq 17(1): 8-14.
  19. Caminschi, I., Corbett, A. J , Lahoud, M. & Lew, A.M. (2006). Targeting antigen to dendritic cells. Modern Aspects of Immunobiology 20:10-11.
  20. Lahoud, M. H.#, Proietto, A. I., Gartlan, K. H., Kitsoulis, S., Curtis, J., Wettenhall, J., Sofi, M., Daunt, C., O'Keeffe, M., Caminschi, I., Satterley, K., Rizzitelli, A., Schnorrer, P., Hinohara, A., Yamaguchi, Y., Wu, L., Smyth, G., Handman, E., Shortman, K. and Wright, M. D. (2006). Signal regulatory protein molecules are differentially expressed by CD8- dendritic cells. J Immunol 177(1): 372-382.
  21. Naik, S. H., Proietto, A. I., Wilson, N. S., Dakic, A., Schnorrer, P., Fuchsberger, M., Lahoud, M. H., O'Keeffe, M., Shao, Q. X., Chen, W. F., Villadangos, J. A., Shortman, K. and Wu, L. (2005). Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures. J Immunol 174(11): 6592-6597.
Protocols by Mireille H. Lahoud
  1. Co-sedimentation Assay for the Detection of Direct Binding to F-actin