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Sung Hoon Back

Education

Ph.D. in Molecular Virology, Department of Life Science, Pohang University of Science and Technology (POSTECH), 2002

Current position

Assistant Professor, School of Biological Sciences, University of Ulsan, Ulsan, Korea (2010-present)

Publications

  1. Misra, J., Kim, D. K., Choi, W., Koo, S. H., Lee, C. H., Back, S. H., Kaufman, R. J. and Choi, H. S. (2013). Transcriptional cross talk between orphan nuclear receptor ERRgamma and transmembrane transcription factor ATF6alpha coordinates endoplasmic reticulum stress response. Nucleic Acids Res 41(14): 6960-6974.
  2. Han, J.*, Back, S. H.*, Hur, J., Lin, Y. H., Gildersleeve, R., Shan, J., Yuan, C. L., Krokowski, D., Wang, S., Hatzoglou, M., Kilberg, M. S., Sartor, M. A. and Kaufman, R. J. (2013). ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol 15(5): 481-490. *These authors contributed equally to this work.
  3. Jo, H., Choe, S. S., Shin, K. C., Jang, H., Lee, J. H., Seong, J. K., Back, S. H. and Kim, J. B. (2013). Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor. Hepatology 57(4): 1366-1377.
  4. Kim, K. H., Jeong, Y. T., Oh, H., Kim, S. H., Cho, J. M., Kim, Y. N., Kim, S. S., Kim do, H., Hur, K. Y., Kim, H. K., Ko, T., Han, J., Kim, H. L., Kim, J., Back, S. H., Komatsu, M., Chen, H., Chan, D. C., Konishi, M., Itoh, N., Choi, C. S. and Lee, M. S. (2013). Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med 19(1): 83-92.
  5. Back, S. H. and Kaufman, R. J. (2012). Endoplasmic reticulum stress and type 2 diabetes. Annu Rev Biochem 81: 767-793.
  6. Zheng, M., Kim, S. K., Joe, Y., Back, S. H., Cho, H. R., Kim, H. P., Ignarro, L. J. and Chung, H. T. (2012). Sensing endoplasmic reticulum stress by protein kinase RNA-like endoplasmic reticulum kinase promotes adaptive mitochondrial DNA biogenesis and cell survival via heme oxygenase-1/carbon monoxide activity. FASEB J 26(6): 2558-2568.
  7. Heo, S. K., Ju, S. A., Kim, G. Y., Park, S. M., Back, S. H., Park, N. H., Min, Y. J., An, W. G., Nguyen, T. T., Kim, S. M. and Kim, B. S. (2012). The presence of high level soluble herpes virus entry mediator in sera of gastric cancer patients. Exp Mol Med 44(2): 149-158.
  8. Misra, J., Chanda, D., Kim, D. K., Li, T., Koo, S. H., Back, S. H., Chiang, J. Y. and Choi, H. S. (2011). Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE (small heterodimer partner-interacting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H). J Biol Chem 286(49): 41972-41984.
  9. Back, S. H., Kang, S. W., Han, J. and Chung, H. T. (2012). Endoplasmic reticulum stress in the beta-cell pathogenesis of type 2 diabetes. Exp Diabetes Res 2012: 618396.
  10. Zhang, K., Wang, S., Malhotra, J., Hassler, J. R., Back, S. H., Wang, G., Chang, L., Xu, W., Miao, H., Leonardi, R., Chen, Y. E., Jackowski, S. and Kaufman, R. J. (2011). The unfolded protein response transducer IRE1alpha prevents ER stress-induced hepatic steatosis. EMBO J 30(7): 1357-1375.
  11. Kim, H. P., Pae, H. O., Back, S. H., Chung, S. W., Woo, J. M., Son, Y. and Chung, H. T. (2011). Heme oxygenase-1 comes back to endoplasmic reticulum. Biochem Biophys Res Commun 404(1): 1-5.
  12. Kaufman, R. J., Back, S. H., Song, B., Han, J. and Hassler, J. (2010). The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in beta-cells. Diabetes Obes Metab 12 Suppl 2: 99-107.
  13. Back, S. H.*, Scheuner, D.*, Han, J., Song, B., Ribick, M., Wang, J., Gildersleeve, R. D., Pennathur, S. and Kaufman, R. J. (2009). Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab 10(1): 13-26. *These authors contributed equally to this work.
  14. Bommiasamy, H.*, Back, S. H.*, Fagone, P., Lee, K., Meshinchi, S., Vink, E., Sriburi, R., Frank, M., Jackowski, S., Kaufman, R. J. and Brewer, J. W. (2009). ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum. J Cell Sci 122(Pt 10): 1626-1636. *These authors contributed equally to this work.
  15. Back, S. H., Hassler, J. R., and Kaufman, R. J. (2009). The Unfolded Protein Response in Mammalian Cells. Bentham Science eBooks (Protein Misfolding Disorders: A trip to the ER, eISBN: 978-1-60805-013-0)
  16. Rutkowski, D. T., Wu, J., Back, S. H., Callaghan, M. U., Ferris, S. P., Iqbal, J., Clark, R., Miao, H., Hassler, J. R., Fornek, J., Katze, M. G., Hussain, M. M., Song, B., Swathirajan, J., Wang, J., Yau, G. D. and Kaufman, R. J. (2008). UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell 15(6): 829-840.
  17. Zhou, J., Liu, C. Y., Back, S. H., Clark, R. L., Peisach, D., Xu, Z. and Kaufman, R. J. (2006). The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc Natl Acad Sci U S A 103(39): 14343-14348.
  18. Zhang, K., Shen, X., Wu, J., Sakaki, K., Saunders, T., Rutkowski, D. T., Back, S. H. and Kaufman, R. J. (2006). Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124(3): 587-599.
  19. Back, S. H., Lee, K., Vink, E. and Kaufman, R. J. (2006). Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress. J Biol Chem 281(27): 18691-18706.
  20. Back, S. H., Schroder, M., Lee, K., Zhang, K. and Kaufman, R. J. (2005). ER stress signaling by regulated splicing: IRE1/HAC1/XBP1. Methods 35(4): 395-416.
  21. Cho, S., Kim, J. H., Back, S. H. and Jang, S. K. (2005). Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase. Mol Cell Biol 25(4): 1283-1297.
  22. Kim, W. J.*, Back, S. H.*, Kim, V., Ryu, I. and Jang, S. K. (2005). Sequestration of TRAF2 into stress granules interrupts tumor necrosis factor signaling under stress conditions. Mol Cell Biol 25(6): 2450-2462. *These authors contributed equally to this work.
  23. Back, S. H., Shin, S. and Jang, S. K. (2002). Polypyrimidine tract-binding proteins are cleaved by caspase-3 during apoptosis. J Biol Chem 277(30): 27200-27209.
  24. Back, S. H., Kim, Y. K., Kim, W. J., Cho, S., Oh, H. R., Kim, J. E. and Jang, S. K. (2002). Translation of polioviral mRNA is inhibited by cleavage of polypyrimidine tract-binding proteins executed by polioviral 3C(pro). J Virol 76(5): 2529-2542.
  25. Kim, Y. K., Back, S. H., Rho, J., Lee, S. H. and Jang, S. K. (2001). La autoantigen enhances translation of BiP mRNA. Nucleic Acids Res 29(24): 5009-5016.
  26. Kim, S. Y., Park, K. W., Lee, Y. J., Back, S. H., Goo, J. H., Park, O. K., Jang, S. K. and Park, W. J. (2000). In vivo determination of substrate specificity of hepatitis C virus NS3 protease: genetic assay for site-specific proteolysis. Anal Biochem 284(1): 42-48.
  27. Back, S. H., Kim, J. E., Rho, J., Hahm, B., Lee, T. G., Kim, E. E., Cho, J. M. and Jang, S. K. (2000). Expression and purification of an active, full-length hepatitis C viral NS4A. Protein Expr Purif 20(2): 196-206.
  28. Kim, J. E., Song, W. K., Chung, K. M., Back, S. H. and Jang, S. K. (1999). Subcellular localization of hepatitis C viral proteins in mammalian cells. Arch Virol 144(2): 329-343.
  29. Cho, H. S., Ha, N. C., Kang, L. W., Chung, K. M., Back, S. H., Jang, S. K. and Oh, B. H. (1998). Crystal structure of RNA helicase from genotype 1b hepatitis C virus. A feasible mechanism of unwinding duplex RNA. J Biol Chem 273(24): 15045-15052.
  30. Kang, L. W., Cho, H. S., Cha, S. S., Chung, K. M., Back, S. H., Jang, S. K. and Oh, B. H. (1998). Crystallization and preliminary X-ray crystallographic analysis of the helicase domain of hepatitis C virus NS3 protein. Acta Crystallogr D Biol Crystallogr 54(Pt 1): 121-123.
  31. Hahm, B., Back, S. H., Lee, T. G., Wimmer, E. and Jang, S. K. (1996). Generation of a novel poliovirus with a requirement of hepatitis C virus protease NS3 activity. Virology 226(2): 318-326.
  32. Hahm, B., Han, D. S., Back, S. H., Song, O. K., Cho, M. J., Kim, C. J., Shimotohno, K. and Jang, S. K. (1995). NS3-4A of hepatitis C virus is a chymotrypsin-like protease. J Virol 69(4): 2534-2539.
Protocols by Sung Hoon Back
  1. TRIPLE (Insulin, Glucagon and EGFP) Immunofluorescence Staining Protocol in Pancreas