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Andrea   Introini

Andrea Introini


Ph.D. in Molecular Medicine, University of Milan, Italy, 2013

Current position

Postdoctoral Research Fellow, Unit of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden


  1. Guthrie, B. L., Introini, A., Roxby, A. C., Choi, R. Y., Bosire, R., Lohman-Payne, B., Hirbod, T., Farquhar, C. and Broliden, K. (2015). Depot medroxyprogesterone acetate (DMPA) use is associated with elevated innate immune effector molecules in cervicovaginal secretions of HIV-1-uninfected women. J Acquir Immune Defic Syndr. (Epub ahead of print)  
  2. Tjernlund, A., Carias, A. M., Andersson, S., Gustafsson-Sanchez, S., Rohl, M., Petersson, P., Introini, A., Hope, T. J. and Broliden, K. (2015). Progesterone-based intrauterine device use is associated with a thinner apical layer of the human ectocervical epithelium and a lower ZO-1 mRNA expression. Biol Reprod. (Epub ahead of print)
  3. Introini, A., Kaldensjo, T., Hirbod, T., Rohl, M., Tjernlund, A., Andersson, S. and Broliden, K. (2014). Expression profiles of antimicrobial peptides in the genital tract of women using progesterone intrauterine devices versus combined oral contraceptives. Am J Reprod Immunol 72(5): 475-484.
  4. Introini, A., Vanpouille, C., Grivel, J. C. and Margolis, L. (2014). An ex vivo model of HIV-1 infection in human lymphoid tissue and cervico-vaginal tissue. Bio-protocol 4(4): e1047.    
  5. McGuigan, C., Bourdin, C., Derudas, M., Hamon, N., Hinsinger, K., Kandil, S., Madela, K., Meneghesso, S., Pertusati, F., Serpi, M., Slusarczyk, M., Chamberlain, S., Kolykhalov, A., Vernachio, J., Vanpouille, C., Introini, A., Margolis, L. and Balzarini, J. (2013). Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides. Eur J Med Chem 70: 326-340.
  6. Balzarini, J., Andrei, G., Balestra, E., Huskens, D., Vanpouille, C., Introini, A., Zicari, S., Liekens, S., Snoeck, R., Holy, A., Perno, C. F., Margolis, L. and Schols, D. (2013). A multi-targeted drug candidate with dual anti-HIV and anti-HSV activity. PLoS Pathog 9(7): e1003456.
  7. Introini, A., Vanpouille, C., Lisco, A., Grivel, J. C. and Margolis, L. (2013). Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo. PLoS Pathog 9(2): e1003148.
  8. Lisco, A., Introini, A., Munawwar, A., Vanpouille, C., Grivel, J. C., Blank, P., Singh, S. and Margolis, L. (2012). HIV-1 imposes rigidity on blood and semen cytokine networks. Am J Reprod Immunol 68(6): 515-521.
  9. Vanpouille, C., Lisco, A., Introini, A., Grivel, J. C., Munawwar, A., Merbah, M., Schinazi, R. F., Derudas, M., McGuigan, C., Balzarini, J. and Margolis, L. (2012). Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin. Antimicrob Agents Chemother 56(5): 2604-2611.
  10. Lisco, A., Munawwar, A., Introini, A., Vanpouille, C., Saba, E., Feng, X., Grivel, J. C., Singh, S. and Margolis, L. (2012). Semen of HIV-1-infected individuals: local shedding of herpesviruses and reprogrammed cytokine network. J Infect Dis 205(1): 97-105.
  11. Andrei, G., Lisco, A., Vanpouille, C., Introini, A., Balestra, E., van den Oord, J., Cihlar, T., Perno, C. F., Snoeck, R., Margolis, L. and Balzarini, J. (2011). Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication. Cell Host Microbe 10(4): 379-389.
  12. Merbah, M.*, Introini, A.*, Fitzgerald, W., Grivel, J. C., Lisco, A., Vanpouille, C. and Margolis, L. (2011). Cervico-vaginal tissue ex vivo as a model to study early events in HIV-1 infection. Am J Reprod Immunol 65(3): 268-278. (*Authors contributed equally)

Book chapters

  1. Broliden, K., Introini, A., Burgener, A. (2014). HIV transmission in female commercial sex workers and host protective factors. In: Encyclopedia of AIDS. Springer.
Protocols by Andrea Introini
  1. An ex vivo Model of HIV-1 Infection in Human Lymphoid Tissue and Cervico-vaginal Tissue