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Giuseppe A. Papalia

Education

Ph.D., Department of Medical Genetics, University of Toronto, 2002

Current position

Senior Scientist, Department of Biochemistry, Gilead Sciences, Foster City, California

Publications

  1. Drake, A. and Papalia, G. (2012). Biophysical considerations for development of antibody-based therapeutics. In: Tabrizi, M., Bornstein, G., Klakamp, S. (eds). Development of Anti-Based Therapeucits. Springer, 95-139.
  2. Drake, A. W., Tang, M. L., Papalia, G. A., Landes, G., Haak-Frendscho, M. and Klakamp, S. L. (2012). Biacore surface matrix effects on the binding kinetics and affinity of an antigen/antibody complex. Anal Biochem 429(1): 58-69.
  3. Papalia, G. and Myszka, D. (2010). Exploring minimal biotinylation conditions for biosensor analysis using capture chips. Anal Biochem 403(1-2): 30-35.
  4. Rich, R. L., Papalia, G. A., Flynn, P. J., Furneisen, J., Quinn, J., Klein, J. S., Katsamba, P. S., Waddell, M. B., Scott, M., Thompson, J., Berlier, J., Corry, S., Baltzinger, M., Zeder-Lutz, G., Schoenemann, A., Clabbers, A., Wieckowski, S., Murphy, M. M., Page, P., Ryan, T. E., Duffner, J., Ganguly, T., Corbin, J., Gautam, S., Anderluh, G., Bavdek, A., Reichmann, D., Yadav, S. P., Hommema, E., Pol, E., Drake, A., Klakamp, S., Chapman, T., Kernaghan, D., Miller, K., Schuman, J., Lindquist, K., Herlihy, K., Murphy, M. B., Bohnsack, R., Andrien, B., Brandani, P., Terwey, D., Millican, R., Darling, R. J., Wang, L., Carter, Q., Dotzlaf, J., Lopez-Sagaseta, J., Campbell, I., Torreri, P., Hoos, S., England, P., Liu, Y., Abdiche, Y., Malashock, D., Pinkerton, A., Wong, M., Lafer, E., Hinck, C., Thompson, K., Primo, C. D., Joyce, A., Brooks, J., Torta, F., Bagge Hagel, A. B., Krarup, J., Pass, J., Ferreira, M., Shikov, S., Mikolajczyk, M., Abe, Y., Barbato, G., Giannetti, A. M., Krishnamoorthy, G., Beusink, B., Satpaev, D., Tsang, T., Fang, E., Partridge, J., Brohawn, S., Horn, J., Pritsch, O., Obal, G., Nilapwar, S., Busby, B., Gutierrez-Sanchez, G., Gupta, R. D., Canepa, S., Witte, K., Nikolovska-Coleska, Z., Cho, Y. H., D'Agata, R., Schlick, K., Calvert, R., Munoz, E. M., Hernaiz, M. J., Bravman, T., Dines, M., Yang, M. H., Puskas, A., Boni, E., Li, J., Wear, M., Grinberg, A., Baardsnes, J., Dolezal, O., Gainey, M., Anderson, H., Peng, J., Lewis, M., Spies, P., Trinh, Q., Bibikov, S., Raymond, J., Yousef, M., Chandrasekaran, V., Feng, Y., Emerick, A., Mundodo, S., Guimaraes, R., McGirr, K., Li, Y. J., Hughes, H., Mantz, H., Skrabana, R., Witmer, M., Ballard, J., Martin, L., Skladal, P., Korza, G., Laird-Offringa, I., Lee, C. S., Khadir, A., Podlaski, F., Neuner, P., Rothacker, J., Rafique, A., Dankbar, N., Kainz, P., Gedig, E., Vuyisich, M., Boozer, C., Ly, N., Toews, M., Uren, A., Kalyuzhniy, O., Lewis, K., Chomey, E., Pak, B. J. and Myszka, D. G. (2009). A global benchmark study using affinity-based biosensors. Anal Biochem 386(2): 194-216.
  5. Eddings, M. A., Eckman, J. W., Arana, C. A., Papalia, G. A., Connolly, J. E., Gale, B. K. and Myszka, D. G. (2009). "Spot and hop": internal referencing for surface plasmon resonance imaging using a three-dimensional microfluidic flow cell array. Anal Biochem 385(2): 309-313.
  6. Papalia, G. A., Giannetti, A. M., Arora, N. and Myszka, D. G. (2008). Thermodynamic characterization of pyrazole and azaindole derivatives binding to p38 mitogen-activated protein kinase using Biacore T100 technology and van't Hoff analysis. Anal Biochem 383(2): 255-264.
  7. Papalia, G. A. and Rini, J. M. (2008). Re-examining the proposed lectin properties of IL-2. Mol Immunol 45(5): 1241-1247.
  8. Natarajan, S., Katsamba, P. S., Miles, A., Eckman, J., Papalia, G. A., Rich, R. L., Gale, B. K. and Myszka, D. G. (2008). Continuous-flow microfluidic printing of proteins for array-based applications including surface plasmon resonance imaging. Anal Biochem 373(1): 141-146.
  9. Copeland, S. J., Green, B. J., Burchat, S., Papalia, G. A., Banner, D. and Copeland, J. W. (2007). The diaphanous inhibitory domain/diaphanous autoregulatory domain interaction is able to mediate heterodimerization between mDia1 and mDia2. J Biol Chem 282(41): 30120-30130.
  10. Navratilova, I., Papalia, G. A., Rich, R. L., Bedinger, D., Brophy, S., Condon, B., Deng, T., Emerick, A. W., Guan, H. W., Hayden, T., Heutmekers, T., Hoorelbeke, B., McCroskey, M. C., Murphy, M. M., Nakagawa, T., Parmeggiani, F., Qin, X., Rebe, S., Tomasevic, N., Tsang, T., Waddell, M. B., Zhang, F. F., Leavitt, S. and Myszka, D. G. (2007). Thermodynamic benchmark study using Biacore technology. Anal Biochem 364(1): 67-77.
  11. Bravman, T., Bronner, V., Lavie, K., Notcovich, A., Papalia, G. A. and Myszka, D. G. (2006). Exploring "one-shot" kinetics and small molecule analysis using the ProteOn XPR36 array biosensor. Anal Biochem 358(2): 281-288.
  12. Papalia, G. A., Leavitt, S., Bynum, M. A., Katsamba, P. S., Wilton, R., Qiu, H., Steukers, M., Wang, S., Bindu, L., Phogat, S., Giannetti, A. M., Ryan, T. E., Pudlak, V. A., Matusiewicz, K., Michelson, K. M., Nowakowski, A., Pham-Baginski, A., Brooks, J., Tieman, B. C., Bruce, B. D., Vaughn, M., Baksh, M., Cho, Y. H., Wit, M. D., Smets, A., Vandersmissen, J., Michiels, L. and Myszka, D. G. (2006). Comparative analysis of 10 small molecules binding to carbonic anhydrase II by different investigators using Biacore technology. Anal Biochem 359(1): 94-105.
  13. Papalia, G. A., Baer, M., Luehrsen, K., Nordin, H., Flynn, P. and Myszka, D. G. (2006). High-resolution characterization of antibody fragment/antigen interactions using Biacore T100. Anal Biochem 359(1): 112-119.
  14. Cannon, M. J., Papalia, G. A., Navratilova, I., Fisher, R. J., Roberts, L. R., Worthy, K. M., Stephen, A. G., Marchesini, G. R., Collins, E. J., Casper, D., Qiu, H., Satpaev, D., Liparoto, S. F., Rice, D. A., Gorshkova, II, Darling, R. J., Bennett, D. B., Sekar, M., Hommema, E., Liang, A. M., Day, E. S., Inman, J., Karlicek, S. M., Ullrich, S. J., Hodges, D., Chu, T., Sullivan, E., Simpson, J., Rafique, A., Luginbuhl, B., Westin, S. N., Bynum, M., Cachia, P., Li, Y. J., Kao, D., Neurauter, A., Wong, M., Swanson, M. and Myszka, D. G. (2004). Comparative analyses of a small molecule/enzyme interaction by multiple users of Biacore technology. Anal Biochem 330(1): 98-113.
Protocols by Giuseppe A. Papalia
  1. A Surface Plasmon Resonance Method to Study HCV NS5B Inhibitors