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Melanie Wong

Education

Master of Science, Department of Laboratory Medicine & Pathobiology, University of Toronto, 1999

Current position

Associate Scientist, Department of Biochemistry, Gilead Sciences, Foster City, California

Publications

  1. Boyce, S. E., Tirunagari, N., Niedziela-Majka, A., Perry, J., Wong, M., Kan, E., Lagpacan, L., Barauskas, O., Hung, M., Fenaux, M., Appleby, T., Watkins, W. J., Schmitz, U. and Sakowicz, R. (2014). Structural and Regulatory Elements of HCV NS5B Polymerase - beta-Loop and C-Terminal Tail - Are Required for Activity of Allosteric Thumb Site II Inhibitors. PLoS One 9(1): e84808.
  2. Hung, M., Niedziela-Majka, A., Jin, D., Wong, M., Leavitt, S., Brendza, K. M., Liu, X. and Sakowicz, R. (2013). Large-scale functional purification of recombinant HIV-1 capsid. PLoS One 8(3): e58035.
  3. Canales, E., Carlson, J. S., Appleby, T., Fenaux, M., Lee, J., Tian, Y., Tirunagari, N., Wong, M. and Watkins, W. J. (2012). Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors. Bioorg Med Chem Lett 22(13): 4288-4292.
  4. Culp, P. A., Choi, D., Zhang, Y., Yin, J., Seto, P., Ybarra, S. E., Su, M., Sho, M., Steinle, R., Wong, M. H., Evangelista, F., Grove, J., Cardenas, M., James, M., Hsi, E. D., Chao, D. T., Powers, D. B., Ramakrishnan, V. and Dubridge, R. (2010). Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms. Clin Cancer Res 16(2): 497-508.
  5. Rich, R. L., Papalia, G. A., Flynn, P. J., Furneisen, J., Quinn, J., Klein, J. S., Katsamba, P. S., Waddell, M. B., Scott, M., Thompson, J., Berlier, J., Corry, S., Baltzinger, M., Zeder-Lutz, G., Schoenemann, A., Clabbers, A., Wieckowski, S., Murphy, M. M., Page, P., Ryan, T. E., Duffner, J., Ganguly, T., Corbin, J., Gautam, S., Anderluh, G., Bavdek, A., Reichmann, D., Yadav, S. P., Hommema, E., Pol, E., Drake, A., Klakamp, S., Chapman, T., Kernaghan, D., Miller, K., Schuman, J., Lindquist, K., Herlihy, K., Murphy, M. B., Bohnsack, R., Andrien, B., Brandani, P., Terwey, D., Millican, R., Darling, R. J., Wang, L., Carter, Q., Dotzlaf, J., Lopez-Sagaseta, J., Campbell, I., Torreri, P., Hoos, S., England, P., Liu, Y., Abdiche, Y., Malashock, D., Pinkerton, A., Wong, M., Lafer, E., Hinck, C., Thompson, K., Primo, C. D., Joyce, A., Brooks, J., Torta, F., Bagge Hagel, A. B., Krarup, J., Pass, J., Ferreira, M., Shikov, S., Mikolajczyk, M., Abe, Y., Barbato, G., Giannetti, A. M., Krishnamoorthy, G., Beusink, B., Satpaev, D., Tsang, T., Fang, E., Partridge, J., Brohawn, S., Horn, J., Pritsch, O., Obal, G., Nilapwar, S., Busby, B., Gutierrez-Sanchez, G., Gupta, R. D., Canepa, S., Witte, K., Nikolovska-Coleska, Z., Cho, Y. H., D'Agata, R., Schlick, K., Calvert, R., Munoz, E. M., Hernaiz, M. J., Bravman, T., Dines, M., Yang, M. H., Puskas, A., Boni, E., Li, J., Wear, M., Grinberg, A., Baardsnes, J., Dolezal, O., Gainey, M., Anderson, H., Peng, J., Lewis, M., Spies, P., Trinh, Q., Bibikov, S., Raymond, J., Yousef, M., Chandrasekaran, V., Feng, Y., Emerick, A., Mundodo, S., Guimaraes, R., McGirr, K., Li, Y. J., Hughes, H., Mantz, H., Skrabana, R., Witmer, M., Ballard, J., Martin, L., Skladal, P., Korza, G., Laird-Offringa, I., Lee, C. S., Khadir, A., Podlaski, F., Neuner, P., Rothacker, J., Rafique, A., Dankbar, N., Kainz, P., Gedig, E., Vuyisich, M., Boozer, C., Ly, N., Toews, M., Uren, A., Kalyuzhniy, O., Lewis, K., Chomey, E., Pak, B. J. and Myszka, D. G. (2009). A global benchmark study using affinity-based biosensors. Anal Biochem 386(2): 194-216.
  6. Hsi, E. D., Steinle, R., Balasa, B., Szmania, S., Draksharapu, A., Shum, B. P., Huseni, M., Powers, D., Nanisetti, A., Zhang, Y., Rice, A. G., van Abbema, A., Wong, M., Liu, G., Zhan, F., Dillon, M., Chen, S., Rhodes, S., Fuh, F., Tsurushita, N., Kumar, S., Vexler, V., Shaughnessy, J. D., Jr., Barlogie, B., van Rhee, F., Hussein, M., Afar, D. E. and Williams, M. B. (2008). CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma. Clin Cancer Res 14(9): 2775-2784.
  7. Bhaskar, V., Zhang, D., Fox, M., Seto, P., Wong, M. H., Wales, P. E., Powers, D., Chao, D. T., Dubridge, R. B. and Ramakrishnan, V. (2007). A function blocking anti-mouse integrin alpha5beta1 antibody inhibits angiogenesis and impedes tumor growth in vivo. J Transl Med 5: 61.
  8. Ramakrishnan, V., Bhaskar, V., Law, D. A., Wong, M. H., DuBridge, R. B., Breinberg, D., O'Hara, C., Powers, D. B., Liu, G., Grove, J., Hevezi, P., Cass, K. M., Watson, S., Evangelista, F., Powers, R. A., Finck, B., Wills, M., Caras, I., Fang, Y., McDonald, D., Johnson, D., Murray, R. and Jeffry, U. (2006). Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent. J Exp Ther Oncol 5(4): 273-286.
  9. Cannon, M. J., Papalia, G. A., Navratilova, I., Fisher, R. J., Roberts, L. R., Worthy, K. M., Stephen, A. G., Marchesini, G. R., Collins, E. J., Casper, D., Qiu, H., Satpaev, D., Liparoto, S. F., Rice, D. A., Gorshkova, II, Darling, R. J., Bennett, D. B., Sekar, M., Hommema, E., Liang, A. M., Day, E. S., Inman, J., Karlicek, S. M., Ullrich, S. J., Hodges, D., Chu, T., Sullivan, E., Simpson, J., Rafique, A., Luginbuhl, B., Westin, S. N., Bynum, M., Cachia, P., Li, Y. J., Kao, D., Neurauter, A., Wong, M., Swanson, M. and Myszka, D. G. (2004). Comparative analyses of a small molecule/enzyme interaction by multiple users of Biacore technology. Anal Biochem 330(1): 98-113.
  10. Afar, D. E., Bhaskar, V., Ibsen, E., Breinberg, D., Henshall, S. M., Kench, J. G., Drobnjak, M., Powers, R., Wong, M., Evangelista, F., O'Hara, C., Powers, D., DuBridge, R. B., Caras, I., Winter, R., Anderson, T., Solvason, N., Stricker, P. D., Cordon-Cardo, C., Scher, H. I., Grygiel, J. J., Sutherland, R. L., Murray, R., Ramakrishnan, V. and Law, D. A. (2004). Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer. Mol Cancer Ther 3(8): 921-932.
  11. Henshall, S. M., Afar, D. E., Rasiah, K. K., Horvath, L. G., Gish, K., Caras, I., Ramakrishnan, V., Wong, M., Jeffry, U., Kench, J. G., Quinn, D. I., Turner, J. J., Delprado, W., Lee, C. S., Golovsky, D., Brenner, P. C., O'Neill, G. F., Kooner, R., Stricker, P. D., Grygiel, J. J., Mack, D. H. and Sutherland, R. L. (2003). Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer. Oncogene 22(38): 6005-6012.
  12. Howard, P. L., Dally, G. Y., Wong, M. H., Ho, A., Weleber, R. G., Pillers, D. A. and Ray, P. N. (1998). Localization of dystrophin isoform Dp71 to the inner limiting membrane of the retina suggests a unique functional contribution of Dp71 in the retina. Hum Mol Genet 7(9): 1385-1391.
  13. Wong, M. (1993). PATHOGENESIS AND TREATMENT OF CHEYNE-STOKES RESPIRATION WITH CONGESTIVE HEART FAILURE. APSS Newsletter 8(3): 31-32
Protocols by Melanie Wong
  1. A Surface Plasmon Resonance Method to Study HCV NS5B Inhibitors