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Jose Francisco Abisambra

Education

Ph.D., Medical Sciences, University of South Florida, Department of Molecular Medicine, College of Medicine, Tampa, FL., 2010

Current position

Assistant Professor, University of Kentucky, Sanders-Brown Center on Aging and Department of Physiology (2013-present)

Publications

  1. Abisambra, J. F.* and Stephen, S. Brain injury in the context of tauopathies. J Alzheimers Dis. (in press)
  2. Abisambra, J. F., Jinwal, U. K., Blair, L. J., O'Leary, J. C., 3rd, Li, Q., Brady, S., Wang, L., Guidi, C. E., Zhang, B., Nordhues, B. A., Cockman, M., Suntharalingham, A., Li, P., Jin, Y., Atkins, C. A. and Dickey, C. A. (2013). Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation. J Neurosci 33(22): 9498-9507.
  3. Abisambra, J., Jinwal, U. K., Miyata, Y., Rogers, J., Blair, L., Li, X., Seguin, S. P., Wang, L., Jin, Y., Bacon, J., Brady, S., Cockman, M., Guidi, C., Zhang, J., Koren, J., Young, Z. T., Atkins, C. A., Zhang, B., Lawson, L. Y., Weeber, E. J., Brodsky, J. L., Gestwicki, J. E. and Dickey, C. A. (2013). Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biol Psychiatry 74(5): 367-374.
  4. Jinwal, U. K., Akoury, E., Abisambra, J. F., O'Leary, J. C., 3rd, Thompson, A. D., Blair, L. J., Jin, Y., Bacon, J., Nordhues, B. A., Cockman, M., Zhang, J., Li, P., Zhang, B., Borysov, S., Uversky, V. N., Biernat, J., Mandelkow, E., Gestwicki, J. E., Zweckstetter, M. and Dickey, C. A. (2013). Imbalance of Hsp70 family variants fosters tau accumulation. FASEB J 27(4): 1450-1459.
  5. Suntharalingam, A., Abisambra, J. F., O'Leary, J. C., Koren, J., Zhang, B., Joe, M. K., Blair, L. J., Hill, S. E., Jinwal, U. K. and Cockman, M. (2012). Grp94 triage of mutant myocilin through ERAD subverts a more efficient autophagic clearance mechanism. Journal of Biological Chemistry. (E-pub ahead of print)
  6. Jinwal, U. K., Abisambra, J. F., Zhang, J., Dharia, S., O'Leary, J. C., Patel, T., Braswell, K., Jani, T., Gestwicki, J. E. and Dickey, C. A. (2012). Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein. J Biol Chem 287(29): 24814-24820.
  7. Abisambra, J. F., Jinwal, U. K., Suntharalingam, A., Arulselvam, K., Brady, S., Cockman, M., Jin, Y., Zhang, B. and Dickey, C. A. (2012). DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau. J Mol Biol 421(4-5): 653-661. (E-pub ahead of print)
  8. Abisambra, J. F., Jinwal, U. K., Jones, J. R., Blair, L. J., Koren, J., 3rd and Dickey, C. A. (2011). Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics. Curr Neuropharmacol 9(4): 623-631.
  9. Trotter, J. H., Klein, M., Jinwal, U. K., Abisambra, J. F., Dickey, C. A., Tharkur, J., Masiulis, I., Ding, J., Locke, K. G., Rickman, C. B., Birch, D. G., Weeber, E. J. and Herz, J. (2011). ApoER2 function in the establishment and maintenance of retinal synaptic connectivity. J Neurosci 31(40): 14413-14423.
  10. Jones, J. R., Lebar, M. D., Jinwal, U. K., Abisambra, J. F., Koren, J., 3rd, Blair, L., O'Leary, J. C., Davey, Z., Trotter, J., Johnson, A. G., Weeber, E., Eckman, C. B., Baker, B. J. and Dickey, C. A. (2011). The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau. J Nat Prod 74(1): 38-44.
  11. Jinwal, U. K., Trotter, J. H., Abisambra, J. F., Koren, J., 3rd, Lawson, L. Y., Vestal, G. D., O'Leary, J. C., 3rd, Johnson, A. G., Jin, Y., Jones, J. R., Li, Q., Weeber, E. J. and Dickey, C. A. (2011). The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics. J Biol Chem 286(19): 16976-16983.
  12. Abisambra, J. F., Blair, L. J., Hill, S. E., Jones, J. R., Kraft, C., Rogers, J., Koren, J., 3rd, Jinwal, U. K., Lawson, L., Johnson, A. G., Wilcock, D., O'Leary, J. C., Jansen-West, K., Muschol, M., Golde, T. E., Weeber, E. J., Banko, J. and Dickey, C. A. (2010). Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. J Neurosci 30(46): 15374-15382.
  13. O'Leary, J. C., 3rd, Li, Q., Marinec, P., Blair, L. J., Congdon, E. E., Johnson, A. G., Jinwal, U. K., Koren, J., 3rd, Jones, J. R., Kraft, C., Peters, M., Abisambra, J. F., Duff, K. E., Weeber, E. J., Gestwicki, J. E. and Dickey, C. A. (2010). Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Mol Neurodegener 5: 45.
  14. Abisambra, J. F., Fiorelli, T., Padmanabhan, J., Neame, P., Wefes, I. and Potter, H. (2010). LDLR expression and localization are altered in mouse and human cell culture models of Alzheimer's disease. PLoS One 5(1): e8556.
  15. Jinwal, U. K., John Koren III, J. C., Leary III, J. R. J., Abisambra, J. F. and Dickey, C. A. (2010). Hsp70 ATPase modulators as therapeutics for Alzheimer’s and other neurodegenerative diseases. Molecular and cellular pharmacology 2(2): 43.
  16. Jinwal, U. K., Koren, J., 3rd, Borysov, S. I., Schmid, A. B., Abisambra, J. F., Blair, L. J., Johnson, A. G., Jones, J. R., Shults, C. L., O'Leary, J. C., 3rd, Jin, Y., Buchner, J., Cox, M. B. and Dickey, C. A. (2010). The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. J Neurosci 30(2): 591-599.
  17. Jinwal, U. K., O'Leary, J. C., 3rd, Borysov, S. I., Jones, J. R., Li, Q., Koren, J., 3rd, Abisambra, J. F., Vestal, G. D., Lawson, L. Y., Johnson, A. G., Blair, L. J., Jin, Y., Miyata, Y., Gestwicki, J. E. and Dickey, C. A. (2010). Hsc70 rapidly engages tau after microtubule destabilization. J Biol Chem 285(22): 16798-16805.
  18. Koren, J., 3rd, Jinwal, U. K., Jin, Y., O'Leary, J., Jones, J. R., Johnson, A. G., Blair, L. J., Abisambra, J. F., Chang, L., Miyata, Y., Cheng, A. M., Guo, J., Cheng, J. Q., Gestwicki, J. E. and Dickey, C. A. (2010). Facilitating Akt clearance via manipulation of Hsp70 activity and levels. J Biol Chem 285(4): 2498-2505.
  19. Lopez, D., Abisambra Socarras, J. F., Bedi, M. and Ness, G. C. (2007). Activation of the hepatic LDL receptor promoter by thyroid hormone. Biochim Biophys Acta 1771(9): 1216-1225.

Book chapters

  1. Anderson, A. J. and Abisambra, J. (In press). Pick’s disease: The evolutoin of theory and knowledge in neurodegenerative tauopathies. Diet and Nutrition in Dementia and Cognitive Decline, Colin R. Martin and Victor R. Preedy, Editors. Elsevier Publishers.
Protocols by Jose Francisco Abisambra
  1. Microsome Isolation from Tissue