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Warren Tourtellotte

Education

M.D., University of Iowa, 1992
Ph.D. in Molecular Neuroscience, University of Iowa, 1991

Current position

Associate Professor in Pathology and Neurology, Department of Pathology, Northwestern University, Chicago, Illinois

Publications (since 2005)

  1. Fang, F., Shangguan, A. J., Kelly, K., Wei, J., Gruner, K., Ye, B., Wang, W., Bhattacharyya, S., Hinchcliff, M. E. and Tourtellotte, W. G. (2013). Early Growth Response 3 (Egr-3) Is Induced by Transforming Growth Factor-β and Regulates Fibrogenic Responses. The American journal of pathology 183(4): 1197-1208.
  2. Quach, D. H., Oliveira-Fernandes, M., Gruner, K. A. and Tourtellotte, W. G. (2013). A sympathetic neuron autonomous role for Egr3-mediated gene regulation in dendrite morphogenesis and target tissue innervation. J Neurosci 33(10): 4570-4583.
  3. Bhattacharyya, S., Fang, F., Tourtellotte, W. and Varga, J. (2013). Egr-1: new conductor for the tissue repair orchestra directs harmony (regeneration) or cacophony (fibrosis). J Pathol 229(2): 286-297.
  4. Bhalala, O. G., Pan, L., Sahni, V., McGuire, T. L., Gruner, K., Tourtellotte, W. G. and Kessler, J. A. (2012). microRNA-21 regulates astrocytic response following spinal cord injury. J Neurosci 32(50): 17935-17947.
  5. Bhattacharyya, S., Wei, J., Tourtellotte, W. G., Hinchcliff, M., Gottardi, C. G. and Varga, J. (2012). Fibrosis in systemic sclerosis: common and unique pathobiology. Fibrogenesis Tissue Repair 5 Suppl 1: S18.
  6. Enjin, A., Leão, K. E., Mikulovic, S., Le Merre, P., Tourtellotte, W. G. and Kullander, K. (2012). Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons. Molecular and Cellular Neuroscience 49(3): 322-332.
  7. Li, L., Eldredge, L. C., Quach, D. H., Honasoge, A., Gruner, K. and Tourtellotte, W. G. (2011). Egr3 dependent sympathetic target tissue innervation in the absence of neuron death. PLoS One 6(9): e25696.
  8. Bhattacharyya, S., Sargent, J. L., Du, P., Lin, S., Tourtellotte, W. G., Takehara, K., Whitfield, M. L. and Varga, J. (2011). Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis. PLoS One 6(9): e23082.
  9. Bhattacharyya, S., Wu, M., Fang, F., Tourtellotte, W., Feghali-Bostwick, C. and Varga, J. (2011). Early growth response transcription factors: key mediators of fibrosis and novel targets for anti-fibrotic therapy. Matrix Biol 30(4): 235-242.
  10. Wei, J., Bhattacharyya, S., Tourtellotte, W. G. and Varga, J. (2011). Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy. Autoimmun Rev 10(5): 267-275.
  11. Enjin, A., Rabe, N., Nakanishi, S. T., Vallstedt, A., Gezelius, H., Memic, F., Lind, M., Hjalt, T., Tourtellotte, W. G., Bruder, C., Eichele, G., Whelan, P. J. and Kullander, K. (2010). Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells. J Comp Neurol 518(12): 2284-2304.
  12. Wu, M., Melichian, D. S., de la Garza, M., Gruner, K., Bhattacharyya, S., Barr, L., Nair, A., Shahrara, S., Sporn, P. H., Mustoe, T. A., Tourtellotte, W. G. and Varga, J. (2009). Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing. Am J Pathol 175(3): 1041-1055.
  13. Eldredge, L. C., Gao, X. M., Quach, D. H., Li, L., Han, X., Lomasney, J. and Tourtellotte, W. G. (2008). Abnormal sympathetic nervous system development and physiological dysautonomia in Egr3-deficient mice. Development 135(17): 2949-2957.
  14. Gao, X., Daugherty, R. L. and Tourtellotte, W. G. (2007). Regulation of low affinity neurotrophin receptor (p75(NTR)) by early growth response (Egr) transcriptional regulators. Mol Cell Neurosci 36(4): 501-514.
  15. Carter, J. H., Lefebvre, J. M., Wiest, D. L. and Tourtellotte, W. G. (2007). Redundant role for early growth response transcriptional regulators in thymocyte differentiation and survival. The Journal of Immunology 178(11): 6796-6805.
  16. Li, L., Yun, S. H., Keblesh, J., Trommer, B. L., Xiong, H., Radulovic, J. and Tourtellotte, W. G. (2007). Egr3, a synaptic activity regulated transcription factor that is essential for learning and memory. Mol Cell Neurosci 35(1): 76-88.
  17. Carter, J. H. and Tourtellotte, W. G. (2007). Early growth response transcriptional regulators are dispensable for macrophage differentiation. J Immunol 178(5): 3038-3047.
  18. Li, L., Carter, J., Gao, X., Whitehead, J. and Tourtellotte, W. G. (2005). The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors. Molecular and cellular biology 25(23): 10286-10300.
  19. Albert, Y., Whitehead, J., Eldredge, L., Carter, J., Gao, X. and Tourtellotte, W. G. (2005). Transcriptional regulation of myotube fate specification and intrafusal muscle fiber morphogenesis. J Cell Biol 169(2): 257-268.
  20. Whitehead, J., Keller-Peck, C., Kucera, J. and Tourtellotte, W. G. (2005). Glial cell-line derived neurotrophic factor-dependent fusimotor neuron survival during development. Mech Dev 122(1): 27-41.
Protocols by Warren Tourtellotte
  1. Neuron Culture from Mouse Superior Cervical Ganglion