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Peichuan Zhang


Ph.D. in Biology, Pennsylvania State University, PA, 2003

Current position

Associate Specialist, Step 3, University of California, San Francisco


  1. Zhang, P., Judy, M., Lee, S. J. and Kenyon, C. (2013). Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. Cell Metab 17(1): 85-100.
  2. Henis-Korenblit, S., Zhang, P., Hansen, M., McCormick, M., Lee, S. J., Cary, M. and Kenyon, C. (2010). Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A 107(21): 9730-9735.
  3. Yamawaki, T. M., Arantes-Oliveira, N., Berman, J. R., Zhang, P. and Kenyon, C. (2008). Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity. Genetics 178(1): 513-526.
  4. Liang, S. H., Zhang, W., McGrath, B. C., Zhang, P. and Cavener, D. R. (2006). PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis. Biochem J 393(Pt 1): 201-209.
  5. Owen, C. R., Kumar, R., Zhang, P., McGrath, B. C., Cavener, D. R. and Krause, G. S. (2005). PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia. J Neurochem 94(5): 1235-1242.
  6. Li, Y., Iida, K., O'Neil, J., Zhang, P., Li, S., Frank, A., Gabai, A., Zambito, F., Liang, S. H., Rosen, C. J. and Cavener, D. R. (2003). PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. Endocrinology 144(8): 3505-3513.
  7. Zhang, P., McGrath, B. C., Reinert, J., Olsen, D. S., Lei, L., Gill, S., Wek, S. A., Vattem, K. M., Wek, R. C., Kimball, S. R., Jefferson, L. S. and Cavener, D. R. (2002). The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol 22(19): 6681-6688.
  8. Zhang, P., McGrath, B., Li, S., Frank, A., Zambito, F., Reinert, J., Gannon, M., Ma, K., McNaughton, K. and Cavener, D. R. (2002). The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol 22(11): 3864-3874.
  9. Kumar, R., Azam, S., Sullivan, J. M., Owen, C., Cavener, D. R., Zhang, P., Ron, D., Harding, H. P., Chen, J. J., Han, A., White, B. C., Krause, G. S. and DeGracia, D. J. (2001). Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK. J Neurochem 77(5): 1418-1421.
  10. Sun, Y., Zhang, P. and Ru, B. (1999). Study on the Expression of a Kind of Metallothionein and SZ51 Recombinant Protein in the E. Coli BL21 (DE3) plys strain. CHINESE JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 15: 423-427.
Protocols by Peichuan Zhang
  1. PCR-RFLP Genotyping of Point Mutations in Caenorhabditis elegans
  2. [Bio101] Expansion of Worms for Microarray, IP, ChIP and Similar Experiments
  3. [Bio101] Glucose Tolerance Test in Mice
  4. Alcian Blue – Alizarin Red Staining of Mouse Skeleton
  5. Analysis of Mouse Liver Glycogen Content