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Joseph A. Sorg

Education

Ph.D. in Microbiology, The University of Chicago, Chicago, IL, 2006

Current position

Assistant Professor, Department of Biology, TEXAS A&M UNIVERSITY, College Station, TX (2010-present)

Publications

  1. Francis, M. B., Allen, C. A. and Sorg, J. A. (2013). Muricholic acids inhibit Clostridium difficile spore germination and growth. PLoS One 8(9): e73653.
  2. Francis, M. B., Allen, C. A., Shrestha, R. and Sorg, J. A. (2013). Bile acid recognition by the Clostridium difficile germinant receptor, CspC, is important for establishing infection. PLoS Pathog 9(5): e1003356.
  3. Chen, S., Wilson-Stanford, S., Cromwell, W., Hillman, J. D., Guerrero, A., Allen, C. A., Sorg, J. A. and Smith, L. (2013). Site-directed mutations in the lanthipeptide mutacin 1140. Appl Environ Microbiol 79(13): 4015-4023.
  4. Richter, S. G., Elli, D., Kim, H. K., Hendrickx, A. P., Sorg, J. A., Schneewind, O. and Missiakas, D. (2013). Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria. Proc Natl Acad Sci U S A 110(9): 3531-3536.
  5. Allen, C. A., Babakhani, F., Sears, P., Nguyen, L. and Sorg, J. A. (2013). Both fidaxomicin and vancomycin inhibit outgrowth of Clostridium difficile spores. Antimicrob Agents Chemother 57(1): 664-667.
  6. Bouillaut, L., McBride, S. M. and Sorg, J. A.* (2011). Genetic manipulation of Clostridium difficile. Curr Protoc Microbiol Chapter 9: Unit 9A 2.
    *Corresponding author
  7. Sorg, J. A. and Sonenshein, A. L. (2010). Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid. J Bacteriol 192(19): 4983-4990.
  8. Giel, J. L., Sorg, J. A., Sonenshein, A. L. and Zhu, J. (2010). Metabolism of bile salts in mice influences spore germination in Clostridium difficile. PLoS One 5(1): e8740.
  9. Sorg, J. A.* and Dineen, S. S. (2009). Laboratory maintenance of Clostridium difficile. Curr Protoc Microbiol Chapter 9: Unit9A 1.
    *Corresponding author
  10. Sorg, J. A. and Sonenshein, A. L. (2009). Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination. J Bacteriol 191(3): 1115-1117.
  11. Blaylock, B., Sorg, J. A. and Schneewind, O. (2008). Yersinia enterocolitica type III secretion of YopR requires a structure in its mRNA. Mol Microbiol 70(5): 1210-1222.
  12. Riordan, K. E., Sorg, J. A., Berube, B. J. and Schneewind, O. (2008). Impassable YscP substrates and their impact on the Yersinia enterocolitica type III secretion pathway. J Bacteriol 190(18): 6204-6216.
  13. Sorg, J. A. and Sonenshein, A. L. (2008). Bile salts and glycine as cogerminants for Clostridium difficile spores. J Bacteriol 190(7): 2505-2512.
  14. Sorg, J. A., Blaylock, B. and Schneewind, O. (2006). Secretion signal recognition by YscN, the Yersinia type III secretion ATPase. Proc Natl Acad Sci U S A 103(44): 16490-16495.
  15. Sorg, J. A., Miller, N. C., Marketon, M. M. and Schneewind, O. (2005). Rejection of impassable substrates by Yersinia type III secretion machines. J Bacteriol 187(20): 7090-7102.
  16. Sorg, J. A., Miller, N. C. and Schneewind, O. (2005). Substrate recognition of type III secretion machines--testing the RNA signal hypothesis. Cell Microbiol 7(9): 1217-1225.
  17. Goss, J. W.*, Sorg, J. A.*, Ramamurthi, K. S., Ton-That, H. and Schneewind, O. (2004). The secretion signal of YopN, a regulatory protein of the Yersinia enterocolitica type III secretion pathway. J Bacteriol 186(18): 6320-6324.
    *These authors contributed equally to this work.
  18. Cambronne, E. D., Sorg, J. A. and Schneewind, O. (2004). Binding of SycH chaperone to YscM1 and YscM2 activates effector yop expression in Yersinia enterocolitica. J Bacteriol 186(3): 829-841.
Protocols by Joseph A. Sorg
  1. EMS Mutagenesis of Clostridium difficile to Identify Strains with Germination-null Phenotypes
  2. Virulence Studies of Clostridium difficile