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Elizabeth A. Jonas


M.D., New York University School of Medicine, New York, 1986

Current position

Associate Professor proposed for tenure, Department of Internal Medicine and Neurobiology, Yale University School of Medicine

Publications (since 2005)

  1. Sacchetti, S., Alavian, K. N., Lazrove, E. and Jonas, E. A. (2013). F1FO ATPase vesicle preparation and technique for performing patch clamp recordings of submitochondrial vesicle membranes. J Vis Exp(75): e4394.   
  2. Hardwick, J. M., Chen, Y. B. and Jonas, E. A. (2012). Multipolar functions of BCL-2 proteins link energetics to apoptosis. Trends Cell Biol 22(6): 318-328.  
  3. Gray, J. P., Alavian, K. N., Jonas, E. A. and Heart, E. A. (2012). NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic beta-cells. Am J Physiol Endocrinol Metab 303(2): E191-199.   
  4. Ofengeim, D., Chen, Y. B., Miyawaki, T., Li, H., Sacchetti, S., Flannery, R. J., Alavian, K. N., Pontarelli, F., Roelofs, B. A., Hickman, J. A., Hardwick, J. M., Zukin, R. S. and Jonas, E. A. (2012). N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death. Nat Neurosci 15(4): 574-580.   
  5. Alavian, K. N., Dworetzky, S. I., Bonanni, L., Zhang, P., Sacchetti, S., Mariggio, M. A., Onofrj, M., Thomas, A., Li, H., Mangold, J. E., Signore, A. P., Demarco, U., Demady, D. R., Nabili, P., Lazrove, E., Smith, P. J., Gribkoff, V. K. and Jonas, E. A. (2012). Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res 1446: 1-11.   
  6. Alavian, K. N., Li, H., Collis, L., Bonanni, L., Zeng, L., Sacchetti, S., Lazrove, E., Nabili, P., Flaherty, B. and Graham, M. (2011). Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase. Nat Cell Biol 13(10): 1224-1233.
  7. Chen, Y. B., Aon, M. A., Hsu, Y. T., Soane, L., Teng, X., McCaffery, J. M., Cheng, W. C., Qi, B., Li, H., Alavian, K. N., Dayhoff-Brannigan, M., Zou, S., Pineda, F. J., O'Rourke, B., Ko, Y. H., Pedersen, P. L., Kaczmarek, L. K., Jonas, E. A. and Hardwick, J. M. (2011). Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. J Cell Biol 195(2): 263-276.   
  8. Jonas, E. A. (2009). Molecular participants in mitochondrial cell death channel formation during neuronal ischemia. Exp Neurol 218(2): 203-212.   
  9. Jonas, E. A. (2009). Mitochondrial ion channels in ischemic brain injury, In: Haddad, G. G. and Yu, S. P., (eds). Brain Hypoxia and Ischemia: Emphasis on Developmental Aspects. Humana Press.
  10. Jonas, E. A. (2009). Mitochondrial ion channels, new perspectives, In: Gribkoff, V. K. and Kaczmarek, L. K. (eds). Structure, Function and Pharmacology of Neuronal Voltage-Gated Ion Channels. Wiley and Sons.
  11. Berman, S. B., Chen, Y.-b., Qi, B., McCaffery, J. M., Rucker, E. B., Goebbels, S., Nave, K.-A., Arnold, B. A., Jonas, E. A. and Pineda, F. J. (2009). Bcl-xL increases mitochondrial fission, fusion, and biomass in neurons. J Cell Biol 184(5): 707-719.
  12. Zhang, Y., Helm, J. S., Senatore, A., Spafford, J. D., Kaczmarek, L. K. and Jonas, E. A. (2008). PKC-induced intracellular trafficking of Ca(V)2 precedes its rapid recruitment to the plasma membrane. J Neurosci 28(10): 2601-2612.   
  13. Miyawaki, T., Mashiko, T., Ofengeim, D., Flannery, R. J., Noh, K. M., Fujisawa, S., Bonanni, L., Bennett, M. V., Zukin, R. S. and Jonas, E. A. (2008). Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons. Proc Natl Acad Sci U S A 105(12): 4892-4897.   
  14. Li, H., Chen, Y., Jones, A. F., Sanger, R. H., Collis, L. P., Flannery, R., McNay, E. C., Yu, T., Schwarzenbacher, R., Bossy, B., Bossy-Wetzel, E., Bennett, M. V., Pypaert, M., Hickman, J. A., Smith, P. J., Hardwick, J. M. and Jonas, E. A. (2008). Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons. Proc Natl Acad Sci U S A 105(6): 2169-2174.   
  15. Hickman, J. A., Hardwick, J. M., Kaczmarek, L. K. and Jonas, E. A. (2008). Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission. J Neurophysiol 99(3): 1515-1522. 
  16. Gu, X. Q., Siemen, D., Parvez, S., Cheng, Y., Xue, J., Zhou, D., Sun, X., Jonas, E. A. and Haddad, G. G. (2007). Hypoxia increases BK channel activity in the inner mitochondrial membrane. Biochem Biophys Res Commun 358(1): 311-316.    
  17. Carrithers, M. D., Dib-Hajj, S., Carrithers, L. M., Tokmoulina, G., Pypaert, M., Jonas, E. A. and Waxman, S. G. (2007). Expression of the voltage-gated sodium channel NaV1.5 in the macrophage late endosome regulates endosomal acidification. J Immunol 178(12): 7822-7832.    
  18. Jonas, E. A. (2006). Synaptic apoptosis: The life and death of the synapse. Mol Interv 6: 208-222.
  19. Cheng, W. C., Berman, S. B., Ivanovska, I., Jonas, E. A., Lee, S. J., Chen, Y., Kaczmarek, L. K., Pineda, F. and Hardwick, J. M .(2006). Mitochondrial Factors with Duals Roles in Death and Survival. Oncogene 25, 4697-4705.
  20. Bonanni, L., Chachar, M., Jover-Mengual, T., Li, H., Jones, A., Yokota, H., Ofengeim, D., Flannery, R. J., Miyawaki, T., Cho, C. H., Polster, B. M., Pypaert, M., Hardwick, J. M., Sensi, S. L., Zukin, R. S. and Jonas, E. A. (2006). Zinc-dependent multi-conductance channel activity in mitochondria isolated from ischemic brain. J Neurosci 26(25): 6851-6862.    
  21. Martinez-Caballero, S., Dejean, L. M., Jonas, E. A. and Kinnally, K. W. (2005). The role of the mitochondrial apoptosis induced channel MAC in cytochrome c release. J Bioenerg Biomembr 37(3): 155-164.
  22. Jonas, E. A., Hickman, J. A., Hardwick, J. M. and Kaczmarek, L. K. (2005). Exposure to hypoxia rapidly induces mitochondrial channel activity within a living synapse. J Biol Chem 280(6): 4491-4497.   
  23. Jonas, E. A., Hardwick, J. M. and Kaczmarek, L. K. (2005). Actions of BAX on mitochondrial channel activity and on synaptic transmission. Antioxid Redox Signal 7(9-10): 1092-1100. 
  24. Dejean, L. M., Martinez-Caballero, S., Guo, L., Hughes, C., Teijido, O., Ducret, T., Ichas, F., Korsmeyer, S. J., Antonsson, B. and Jonas, E. A. (2005). Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol Biol Cell 16(5): 2424-2432. 
Protocols by Elizabeth A. Jonas
  1. Mouse Transient Global Ischemia Two-Vessel Occlusion Model
  2. Fluorescent Measurement of Synaptic Activity Using SynaptopHluorin in Isolated Hippocampal Neurons