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Lisardo Boscá

Education

Ph.D. in Biochemistry, Autonomous University, Madrid, 1983

Current position

Senior Research Professor at the Spanish Research Council (CSIC) and director of the Institute of Biomedical Research Alberto Sols, co-shared by CSIC and UAM

Publications (since 2007)

  1. Cosin-Roger, J., Vernia, S., Alvarez, M. S., Cucarella, C., Bosca, L., Martin-Sanz, P., Fernandez-Alvarez, A. J. and Casado, M. (2013). Identification of a novel Pfkfb1 mRNA variant in rat fetal liver. Biochem Biophys Res Commun 431(1): 36-40.
  2. Traves, P. G., Pimentel-Santillana, M., Carrasquero, L. M., Perez-Sen, R., Delicado, E. G., Luque, A., Izquierdo, M., Martin-Sanz, P., Miras-Portugal, M. T. and Bosca, L. (2013). Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses. J Immunol 190(8): 4226-4235.
  3. Llorente-Izquierdo, C., Mayoral, R., Cucarella, C., Grau, C., Alvarez, M. S., Flores, J. M., Garcia-Palencia, P., Agra, N., Castro-Sanchez, L., Bosca, L., Martin-Sanz, P. and Casado, M. (2013). Progression of liver oncogenesis in the double transgenic mice c-myc/TGF alpha is not enhanced by cyclooxygenase-2 expression. Prostaglandins Other Lipid Mediat 106C: 106-115.
  4. Castro-Sanchez, L., Agra, N., Llorente Izquierdo, C., Motino, O., Casado, M., Bosca, L.* and Martin-Sanz, P.* (2013). Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma. Int J Biochem Cell Biol 45(11): 2501-2511. *Corresponding authors
  5. Traves, P. G., Lopez-Fontal, R., Cuadrado, I., Luque, A., Bosca, L., de las Heras, B. and Hortelano, S. (2013). Critical role of the death receptor pathway in the antitumoral effects induced by hispanolone derivatives. Oncogene 32(2): 259-268.
  6. Fernandez-Alvarez, A., Llorente-Izquierdo, C., Mayoral, R., Agra, N., Bosca, L., Casado, M. and Martin-Sanz, P. (2012). Evaluation of epigenetic modulation of cyclooxygenase-2 as a prognostic marker for hepatocellular carcinoma. Oncogenesis 1: e23.
  7. Garcia-Hoz, C., Sanchez-Fernandez, G., Garcia-Escudero, R., Fernandez-Velasco, M., Palacios-Garcia, J., Ruiz-Meana, M., Diaz-Meco, M. T., Leitges, M., Moscat, J., Garcia-Dorado, D., Bosca, L., Mayor, F., Jr. and Ribas, C. (2012). Protein kinase C (PKC)zeta-mediated Galphaq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts. J Biol Chem 287(10): 7792-7802.
  8. Ruiz-Hurtado, G., Gomez-Hurtado, N., Fernandez-Velasco, M., Calderon, E., Smani, T., Ordonez, A., Cachofeiro, V., Bosca, L., Diez, J., Gomez, A. M. and Delgado, C. (2012). Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and arrhythmogenesis in adult rat ventricular myocytes. Cardiovasc Res 96(1): 81-89.
  9. Fernandez-Velasco, M., Prieto, P., Terron, V., Benito, G., Flores, J. M., Delgado, C., Zaragoza, C., Lavin, B., Gomez-Parrizas, M., Lopez-Collazo, E., Martin-Sanz, P. and Bosca, L. (2012). NOD1 activation induces cardiac dysfunction and modulates cardiac fibrosis and cardiomyocyte apoptosis. PLoS One 7(9): e45260.
  10. Agra Andrieu, N., Motino, O., Mayoral, R., Llorente Izquierdo, C., Fernandez-Alvarez, A., Bosca, L., Casado, M. and Martin-Sanz, P. (2012). Cyclooxygenase-2 is a target of microRNA-16 in human hepatoma cells. PLoS One 7(11): e50935.
  11. Garcia-Monzon, C., Lo Iacono, O., Mayoral, R., Gonzalez-Rodriguez, A., Miquilena-Colina, M. E., Lozano-Rodriguez, T., Garcia-Pozo, L., Vargas-Castrillon, J., Casado, M., Bosca, L., Valverde, A. M. and Martin-Sanz, P. (2011). Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C. J Hepatol 54(1): 142-152.
  12. Llorente Izquierdo, C., Mayoral, R., Flores, J. M., Garcia-Palencia, P., Cucarella, C., Bosca, L., Casado, M. and Martin-Sanz, P. (2011). Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis. Am J Pathol 178(3): 1361-1373.
  13. Lopez-Pelaez, M., Soria-Castro, I., Bosca, L., Fernandez, M. and Alemany, S. (2011). Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression. Eur J Immunol 41(6): 1733-1741.
  14. Faine, L. A., Rudnicki, M., Cesar, F. A., Heras, B. L., Bosca, L., Souza, E. S., Hernandes, M. Z., Galdino, S. L., Lima, M. C., Pitta, I. R. and Abdalla, D. S. (2011). Anti-inflammatory and antioxidant properties of a new arylidene-thiazolidinedione in macrophages. Curr Med Chem 18(22): 3351-3360.
  15. Cuadrado, I., Fernandez-Velasco, M., Bosca, L.* and de Las Heras, B.* (2011). Labdane diterpenes protect against anoxia/reperfusion injury in cardiomyocytes: involvement of AKT activation. Cell Death Dis 2: e229. *Corresponding authors
  16. Traves, P. G., de Atauri, P., Marin, S., Pimentel-Santillana, M., Rodriguez-Prados, J. C., Marin de Mas, I., Selivanov, V. A., Martin-Sanz, P., Bosca, L.* and Cascante, M.* (2012). Relevance of the MEK/ERK signaling pathway in the metabolism of activated macrophages: a metabolomic approach. J Immunol 188(3): 1402-1410. *Corresponding authors
  17. Faine, L. A., Cavalcanti, D. M., Rudnicki, M., Ferderbar, S., Macedo, S. M., Souza, H. P., Farsky, S. H., Bosca, L. and Abdalla, D. S. (2010). Bioactivity of nitrolinoleate: effects on adhesion molecules and CD40-CD40L system. J Nutr Biochem 21(2): 125-132.
  18. Mayoral, R., Valverde, A. M., Llorente Izquierdo, C., Gonzalez-Rodriguez, A., Bosca, L. and Martin-Sanz, P. (2010). Impairment of transforming growth factor beta signaling in caveolin-1-deficient hepatocytes: role in liver regeneration. J Biol Chem 285(6): 3633-3642.
  19. Pedrosa, A. M., Faine, L. A., Grosso, D. M., de Las Heras, B., Bosca, L. and Abdalla, D. S. (2010). Electronegative LDL induction of apoptosis in macrophages: involvement of Nrf2. Biochim Biophys Acta 1801(4): 430-437.
  20. Prieto, P., Cuenca, J., Traves, P. G., Fernandez-Velasco, M., Martin-Sanz, P. and Bosca, L. (2010). Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways. Cell Death Differ 17(7): 1179-1188.
  21. Lopez-Fontal, R., Zeini, M., Traves, P. G., Gomez-Ferreria, M., Aranda, A., Saez, G. T., Cerda, C., Martin-Sanz, P., Hortelano, S. and Bosca, L. (2010). Mice lacking thyroid hormone receptor Beta show enhanced apoptosis and delayed liver commitment for proliferation after partial hepatectomy. PLoS One 5(1): e8710.
  22. Martin-Sanz, P., Mayoral, R., Casado, M. and Bosca, L. (2010). COX-2 in liver, from regeneration to hepatocarcinogenesis: what we have learned from animal models? World J Gastroenterol 16(12): 1430-1435.
  23. Hortelano, S., Lopez-Fontal, R., Traves, P. G., Villa, N., Grashoff, C., Bosca, L. and Luque, A. (2010). ILK mediates LPS-induced vascular adhesion receptor expression and subsequent leucocyte trans-endothelial migration. Cardiovasc Res 86(2): 283-292.
  24. Camano, S., Lazaro, A., Moreno-Gordaliza, E., Torres, A. M., de Lucas, C., Humanes, B., Lazaro, J. A., Milagros Gomez-Gomez, M., Bosca, L. and Tejedor, A. (2010). Cilastatin attenuates cisplatin-induced proximal tubular cell damage. J Pharmacol Exp Ther 334(2): 419-429.
  25. Nunez, V., Alameda, D., Rico, D., Mota, R., Gonzalo, P., Cedenilla, M., Fischer, T., Bosca, L., Glass, C. K., Arroyo, A. G. and Ricote, M. (2010). Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression. Proc Natl Acad Sci U S A 107(23): 10626-10631.
  26. Rodriguez-Prados, J. C., Traves, P. G., Cuenca, J., Rico, D., Aragones, J., Martin-Sanz, P., Cascante, M. and Bosca, L. (2010). Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation. J Immunol 185(1): 605-614.
  27. Manarin, R., Pascutti, M. F., Ruffino, J. P., De Las Heras, B., Bosca, L., Bottasso, O., Revelli, S. and Serra, E. (2010). Benznidazole blocks NF-kappaB activation but not AP-1 through inhibition of IKK. Mol Immunol 47(15): 2485-2491.
  28. Inserte, J., Molla, B., Aguilar, R., Traves, P. G., Barba, I., Martin-Sanz, P., Bosca, L., Casado, M. and Garcia-Dorado, D. (2009). Constitutive COX-2 activity in cardiomyocytes confers permanent cardioprotection Constitutive COX-2 expression and cardioprotection. J Mol Cell Cardiol 46(2): 160-168.
  29. Amrani, S., Harnafi, H., Gadi, D., Mekhfi, H., Legssyer, A., Aziz, M., Martin-Nizard, F. and Bosca, L. (2009). Vasorelaxant and anti-platelet aggregation effects of aqueous Ocimum basilicum extract. J Ethnopharmacol 125(1): 157-162.
  30. Giron, N., Traves, P. G., Rodriguez, B., Lopez-Fontal, R., Bosca, L., Hortelano, S. and de las Heras, B. (2008). Suppression of inflammatory responses by labdane-type diterpenoids. Toxicol Appl Pharmacol 228(2): 179-189.
  31. Mayoral, R., Molla, B., Flores, J. M., Bosca, L.*, Casado, M. and Martin-Sanz, P.* (2008). Constitutive expression of cyclo-oxygenase 2 transgene in hepatocytes protects against liver injury. Biochem J 416(3): 337-346. *Corresponding authors.
  32. de Prada, T. P., Pozzi, A. O., Coronado, M. T., Pounchard, M. A., Gonzalez, P., Bosca, L. and Fantidis, P. (2007). Atherogenesis takes place in cholesterol-fed rabbits when circulating concentrations of endogenous cortisol are increased and inflammation suppressed. Atherosclerosis 191(2): 333-339.
  33. Hortelano, S., Zeini, M., Casado, M., Martin-Sanz, P. and Bosca, L. (2007). Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins. Front Biosci 12: 13-21.
  34. Casado, M., Molla, B., Roy, R., Fernandez-Martinez, A., Cucarella, C., Mayoral, R., Bosca, L. and Martin-Sanz, P. (2007). Protection against Fas-induced liver apoptosis in transgenic mice expressing cyclooxygenase 2 in hepatocytes. Hepatology 45(3): 631-638.
  35. Traves, P. G., Hortelano, S., Zeini, M., Chao, T. H., Lam, T., Neuteboom, S. T., Theodorakis, E. A., Palladino, M. A., Castrillo, A. and Bosca, L. (2007). Selective activation of liver X receptors by acanthoic acid-related diterpenes. Mol Pharmacol 71(6): 1545-1553.
  36. Lombardo, E., Alvarez-Barrientos, A., Maroto, B., Bosca, L. and Knaus, U. G. (2007). TLR4-mediated survival of macrophages is MyD88 dependent and requires TNF-alpha autocrine signalling. J Immunol 178(6): 3731-3739.
  37. Mayoral, R., Fernandez-Martinez, A., Roy, R., *Bosca, L. and *Martin-Sanz, P. (2007). Dispensability and dynamics of caveolin-1 during liver regeneration and in isolated hepatic cells. Hepatology 46(3): 813-822 * Corresponding authors
  38. de las Heras, B., Hortelano, S., Giron, N., Bermejo, P., Rodriguez, B. and Bosca, L. (2007). Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages. Br J Pharmacol 152(2): 249-255.
  39. Cuenca, J., Goren, N., Prieto, P., Martin-Sanz, P. and Bosca, L. (2007). Selective impairment of nuclear factor-kappaB-dependent gene transcription in adult cardiomyocytes: relevance for the regulation of the inflammatory response in the heart. Am J Pathol 171(3): 820-828.
  40. Rico, D., Vaquerizas, J. M., Dopazo, H. and Bosca, L. (2007). Identification of conserved domains in the promoter regions of nitric oxide synthase 2: implications for the species-specific transcription and evolutionary differences. BMC Genomics 8: 271.
Protocols by Lisardo Boscá
  1. Determination of the Intracellular Calcium Concentration in Peritoneal Macrophages Using Microfluorimetry