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Donald Caspary


Education

Ph.D. in Biology/Neurobiology, New York University

Current position

Distinguished Scholar and Research Professor, Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
Research interest and specialties:Central Auditory Age-Related Hearing Loss (drug therapy for age-related hearing loss); Central Sensory Plasticity and Tinnitus; Sensory Pharmacology, Anatomy, Physiology, and Neurochemistry (Auditory System)

Publications(selected publications since 2000)

  1. Henry, J.A., L.E. Roberts, D.M. Caspary, S.M. Theodoroff, R.J. Salvi: Underlying Mechanisms of Tinnitus: Review and Clinical Implications. Journal of the American Academy of Audiology (JAAA) Epub 2013.
  2. Richardson, B. D., Hancock, K. E. and Caspary, D. M. (2013). Stimulus-specific adaptation in auditory thalamus of young and aged awake rats. J Neurophysiol 110(8): 1892-1902.
  3. Duque, D., Malmierca, M. S. and Caspary, D. M. (2013). Modulation of stimulus-specific adaptation by GABAA receptor activation or blockade in the medial geniculate body of the anesthetized rat. J Physiol.
  4. Cai, R., Kalappa, B. I., Brozoski, T. J., Ling, L. L. and Caspary, D. M. (2013). Is GABA Neurotransmission Enhanced in Auditory Thalamus Relative to Inferior Colliculus? J Neurophysiol.
  5. Richardson, B. D., Ling, L. L., Uteshev, V. V. and Caspary, D. M. (2013). Reduced GABA(A) receptor-mediated tonic inhibition in aged rat auditory thalamus. J Neurosci 33(3): 1218-1227a.
  6. Caspary, D. M., Hughes, L. F. and Ling, L. L. (2013). Age-related GABAA receptor changes in rat auditory cortex. Neurobiol Aging 34(5): 1486-1496.
  7. Turner, J. G., Parrish, J. L., Zuiderveld, L., Darr, S., Hughes, L. F., Caspary, D. M., Idrezbegovic, E. and Canlon, B. (2013). Acoustic experience alters the aged auditory system. Ear Hear 34(2): 151-159.
  8. Richardson, B. D., Brozoski, T. J., Ling, L. L. and Caspary, D. M. (2012). Targeting inhibitory neurotransmission in tinnitus. Brain Res 1485: 77-87.
  9. Llano, D. A., Turner, J. and Caspary, D. M. (2012). Diminished cortical inhibition in an aging mouse model of chronic tinnitus. J Neurosci 32(46): 16141-16148.
  10. Wang, H., Brozoski, T. J. and Caspary, D. M. (2011). Inhibitory neurotransmission in animal models of tinnitus: maladaptive plasticity. Hear Res 279(1-2): 111-117.
  11. Richardson, B. D., Ling, L. L., Uteshev, V. V. and Caspary, D. M. (2011). Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus. PLoS One 6(1): e16508.
  12. Wang, H., Brozoski, T. J., Ling, L., Hughes, L. F. and Caspary, D. M. (2011). Impact of sound exposure and aging on brain-derived neurotrophic factor and tyrosine kinase B receptors levels in dorsal cochlear nucleus 80 days following sound exposure. Neuroscience 172: 453-459.
  13. Roberts, L. E., Eggermont, J. J., Caspary, D. M., Shore, S. E., Melcher, J. R. and Kaltenbach, J. A. (2010). Ringing ears: the neuroscience of tinnitus. J Neurosci 30(45): 14972-14979.
  14. Brozoski, T. J., Caspary, D. M., Bauer, C. A. and Richardson, B. D. (2010). The effect of supplemental dietary taurine on tinnitus and auditory discrimination in an animal model. Hear Res 270(1-2): 71-80.
  15. Hughes, L. F., Turner, J. G., Parrish, J. L. and Caspary, D. M. (2010). Processing of broadband stimuli across A1 layers in young and aged rats. Hear Res 264(1-2): 79-85.
  16. Wang, H., Brozoski, T. J., Turner, J. G., Ling, L., Parrish, J. L., Hughes, L. F. and Caspary, D. M. (2009). Plasticity at glycinergic synapses in dorsal cochlear nucleus of rats with behavioral evidence of tinnitus. Neuroscience 164(2): 747-759.
  17. Wang, H., Turner, J. G., Ling, L., Parrish, J. L., Hughes, L. F. and Caspary, D. M. (2009). Age-related changes in glycine receptor subunit composition and binding in dorsal cochlear nucleus. Neuroscience 160(1): 227-239.
  18. Schatteman, T. A., Hughes, L. F. and Caspary, D. M. (2008). Aged-related loss of temporal processing: altered responses to amplitude modulated tones in rat dorsal cochlear nucleus. Neuroscience 154(1): 329-337.
  19. Caspary, D. M., Ling, L., Turner, J. G. and Hughes, L. F. (2008). Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory system. J Exp Biol 211(Pt 11): 1781-1791.
  20. Bauer, C. A., Turner, J. G., Caspary, D. M., Myers, K. S. and Brozoski, T. J. (2008). Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma. J Neurosci Res 86(11): 2564-2578.
  21. Caspary, D. M., Hughes, L. F., Schatteman, T. A. and Turner, J. G. (2006). Age-related changes in the response properties of cartwheel cells in rat dorsal cochlear nucleus. Hear Res 216-217: 207-215.
  22. Turner, J. G., Brozoski, T. J., Bauer, C. A., Parrish, J. L., Myers, K., Hughes, L. F. and Caspary, D. M. (2006). Gap detection deficits in rats with tinnitus: a potential novel screening tool. Behav Neurosci 120(1): 188-195.
  23. Brozoski, T. J., Caspary, D. M. and Bauer, C. A. (2006). Marking multi-channel silicon-substrate electrode recording sites using radiofrequency lesions. J Neurosci Methods 150(2): 185-191.
  24. Caspary, D. M., Schatteman, T. A. and Hughes, L. F. (2005). Age-related changes in the inhibitory response properties of dorsal cochlear nucleus output neurons: role of inhibitory inputs. J Neurosci 25(47): 10952-10959.
  25. Turner, J. G., Hughes, L. F. and Caspary, D. M. (2005). Affects of aging on receptive fields in rat primary auditory cortex layer V neurons. J Neurophysiol 94(4): 2738-2747.
  26. Ling, L. L., Hughes, L. F. and Caspary, D. M. (2005). Age-related loss of the GABA synthetic enzyme glutamic acid decarboxylase in rat primary auditory cortex. Neuroscience 132(4): 1103-1113.
  27. Turner, J. G., Parrish, J. L., Hughes, L. F., Toth, L. A. and Caspary, D. M. (2005). Hearing in laboratory animals: strain differences and nonauditory effects of noise. Comp Med 55(1): 12-23.
  28. Turner, J. G., Hughes, L. F. and Caspary, D. M. (2005). Divergent response properties of layer-V neurons in rat primary auditory cortex. Hear Res 202(1-2): 129-140.
  29. Caspary, D. M., Palombi, P. S. and Hughes, L. F. (2002). GABAergic inputs shape responses to amplitude modulated stimuli in the inferior colliculus. Hear Res 168(1-2): 163-173.
  30. Wang, J., McFadden, S. L., Caspary, D. and Salvi, R. (2002). Gamma-aminobutyric acid circuits shape response properties of auditory cortex neurons. Brain Res 944(1-2): 219-231.
  31. Brozoski, T. J., Bauer, C. A. and Caspary, D. M. (2002). Elevated fusiform cell activity in the dorsal cochlear nucleus of chinchillas with psychophysical evidence of tinnitus. J Neurosci 22(6): 2383-2390.
  32. Shaddock Palombi, P., Backoff, P. M. and Caspary, D. M. (2001). Responses of young and aged rat inferior colliculus neurons to sinusoidally amplitude modulated stimuli. Hear Res 153(1-2): 174-180.
  33. Bauer, C. A., Brozoski, T. J., Holder, T. M. and Caspary, D. M. (2000). Effects of chronic salicylate on GABAergic activity in rat inferior colliculus. Hear Res 147(1-2): 175-182.
  34. Milbrandt, J. C., Holder, T. M., Wilson, M. C., Salvi, R. J. and Caspary, D. M. (2000). GAD levels and muscimol binding in rat inferior colliculus following acoustic trauma. Hear Res 147(1-2): 251-260.
Protocols by Donald Caspary
  1. Autoradiographic 3H-Gaboxadol Receptor Binding Protocol