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Dimitry   Ofengeim

Dimitry Ofengeim


Ph.D. in Neuroscience, Albert Einstein College of Medicine, 2010

Current position

He is a postdoctoral fellow in the Department of Cell Biology at Harvard University. His research focuses on understanding the role of neuroinflammation in neurodegenerative diseases


  1. Ofengeim, D. and Yuan, J. (2013). Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nature Rev. Mol. Cell. Biology 14(11):727-36.
  2. Vakifahmetoglu-Norberg, H., Kim, M., Xia, H. G., Iwanicki, M. P., Ofengeim, D., Coloff, J. L., Pan, L., Ince, T. A., Kroemer, G., Brugge, J. S. and Yuan, J. (2013). Chaperone-mediated autophagy degrades mutant p53. Genes Dev 27(15): 1718-1730.
  3. Ofengeim, D., Shi, P., Miao, B., Fan, J., Xia, X., Fan, Y., Lipinski, M. M., Hashimoto, T., Polydoro, M., Yuan, J., Wong, S. T. and Degterev, A. (2012). Identification of small molecule inhibitors of neurite loss induced by Abeta peptide using high content screening. J Biol Chem 287(12): 8714-8723.
  4. Ofengeim, D., Chen, Y. B., Miyawaki, T., Li, H., Sacchetti, S., Flannery, R. J., Alavian, K. N., Pontarelli, F., Roelofs, B. A., Hickman, J. A., Hardwick, J. M., Zukin, R. S. and Jonas, E. A. (2012). N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death. Nat Neurosci 15(4): 574-580.
  5. Miyawaki, T., Ofengeim, D.*, Noh, K. M., Latuszek-Barrantes, A., Hemmings, B. A., Follenzi, A. and Zukin, R. S. (2009). The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death. Nat Neurosci 12(5): 618-626. (*authors contributed equally)
  6. Miyawaki, T., Mashiko, T., Ofengeim, D., Flannery, R. J., Noh, K. M., Fujisawa, S., Bonanni, L., Bennett, M. V., Zukin, R. S. and Jonas, E. A. (2008). Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons. Proc Natl Acad Sci U S A 105(12): 4892-4897.
  7. Bonanni, L., Chachar, M., Jover-Mengual, T., Li, H., Jones, A., Yokota, H., Ofengeim, D., Flannery, R. J., Miyawaki, T. and Cho, C.-H. (2006). Zinc-dependent multi-conductance channel activity in mitochondria isolated from ischemic brain. The Journal of neuroscience 26(25): 6851-6862.
Protocols by Dimitry Ofengeim
  1. Mouse Transient Global Ischemia Two-Vessel Occlusion Model