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George Diallinas

Education

Ph.D. in Molecular Genetics, Universitè Paris-Sud (XI), Paris France,1989

Current position

Professor of Molecular Microbiology, Faculty of Biology, Department of Botany, University of Athens, Panepistimiopolis 15781, Athens, Greece

Publications

Peer-reviewed articles (since 2008)

  1. Diallinas, G. (2013). Allopurinol and xanthine use different translocation mechanisms and trajectories in the fungal UapA transporter. Biochimie 95(9): 1755-1764.
  2. Karachaliou, M., Amillis, S., Evangelinos, M., Kokotos, A. C., Yalelis, V. and Diallinas, G. (2013). The arrestin-like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad-range and specific signals. Mol Microbiol. 88(2):301-17
  3. Krypotou, E., Kosti, V., Amillis, S., Myrianthopoulos, V., Mikros, E. and Diallinas, G. Modeling, Substrate Docking and Mutational Analysis Identify Residues essential for the function and specificity of a Eukaryotic Purine-Cytosine NCS1 Transporter. J Biol Chem. 287(44):36792-803.
  4. Kosti, V., Lambrinidis, G., Myrianthopoulos, V., Diallinas, G. and Mikros, E. (2012). Identification of the substrate recognition and transport pathway in a eukaryotic member of the nucleobase-ascorbate transporter (NAT) family. PLoS One 7(7): e41939.
  5. Leung, J., Karachaliou, M., Alves, C., Diallinas, G. and Byrne, B. (2010). Expression and purification of a functional uric acid-xanthine transporter (UapA). Protein Expr Purif 72(1): 139-146.
  6. Takeshita, N., Diallinas, G. and Fischer, R. (2012). The role of flotillin FloA and stomatin StoA in the maintenance of apical sterol-rich membrane domains and polarity in the filamentous fungus Aspergillus nidulans. Mol Microbiol 83(6): 1136-1152.
  7. Amillis, S., Kosti, V., Pantazopoulou, A., Mikros, E. and Diallinas, G. (2011). Mutational analysis and modeling reveal functionally critical residues in transmembrane segments 1 and 3 of the UapA transporter. J Mol Biol 411(3): 567-580.
  8. Soares-Silva, I., Sa-Pessoa, J., Myrianthopoulos, V., Mikros, E., Casal, M. and Diallinas, G. (2011). A substrate translocation trajectory in a cytoplasm-facing topological model of the monocarboxylate/H(+) symporter Jen1p. Mol Microbiol 81(3): 805-817.
  9. Gournas, C., Oestreicher, N., Amillis, S., Diallinas, G. and Scazzocchio, C. (2011). Completing the purine utilisation pathway of Aspergillus nidulans. Fungal Genet Biol 48(8): 840-848.
  10. Anasontzis, G. E., Zerva, A., Stathopoulou, P. M., Haralampidis, K., Diallinas, G., Karagouni, A. D. and Hatzinikolaou, D. G. (2011). Homologous overexpression of xylanase in Fusarium oxysporum increases ethanol productivity during consolidated bioprocessing (CBP) of lignocellulosics. J Biotechnol 152(1-2): 16-23.
  11. Bitsikas, V., Karachaliou, M., Gournas, C. and Diallinas, G. (2011). Hypertonic conditions trigger transient plasmolysis, growth arrest and blockage of transporter endocytosis in Aspergillus nidulans and Saccharomyces cerevisiae. Mol Membr Biol 28(1): 54-68.
  12. Elsen, S., Efthymiou, G., Peteinatos, P., Diallinas, G., Kyritsis, P. and Moulis, J. M. (2010). A bacteria-specific 2[4Fe-4S] ferredoxin is essential in Pseudomonas aeruginosa. BMC Microbiol 10: 271.
  13. Kosti, V., Papageorgiou, I. and Diallinas, G. (2010). Dynamic elements at both cytoplasmically and extracellularly facing sides of the UapA transporter selectively control the accessibility of substrates to their translocation pathway. J Mol Biol 397(5): 1132-1143.
  14. Leung, J., Karachaliou, M., Alves, C., Diallinas, G. and Byrne, B. (2010). Expression and purification of a functional uric acid-xanthine transporter (UapA). Protein Expr Purif 72(1): 139-146.
  15. Conde, A., Diallinas, G., Chaumont, F., Chaves, M. and Geros, H. (2010). Transporters, channels, or simple diffusion? Dogmas, atypical roles and complexity in transport systems. Int J Biochem Cell Biol 42(6): 857-868.
  16. Gournas, C., Amillis, S., Vlanti, A. and Diallinas, G. (2010). Transport-dependent endocytosis and turnover of a uric acid-xanthine permease. Mol Microbiol 75(1): 246-260.
  17. Vangelatos, I., Vlachakis, D., Sophianopoulou, V. and Diallinas, G. (2009). Modelling and mutational evidence identify the substrate binding site and functional elements in APC amino acid transporters. Mol Membr Biol 26(5): 356-370.
  18. Hamari, Z., Amillis, S., Drevet, C., Apostolaki, A., Vagvolgyi, C., Diallinas, G. and Scazzocchio, C. (2009). Convergent evolution and orphan genes in the Fur4p-like family and characterization of a general nucleoside transporter in Aspergillus nidulans. Mol Microbiol 73(1): 43-57.
  19. Lemuh, N. D., Diallinas, G., Frillingos, S., Mermelekas, G., Karagouni, A. D. and Hatzinikolaou, D. G. (2009). Purification and partial characterization of the xanthine-uric acid transporter (UapA) of Aspergillus nidulans. Protein Expr Purif 63(1): 33-39.
  20. Diallinas, G. (2008). Biochemistry. An almost-complete movie. Science 322(5908): 1644-1645.
  21. Diallinas, G. and Gournas, C. (2008). Structure-function relationships in the nucleobase-ascorbate transporter (NAT) family: lessons from model microbial genetic systems. Channels (Austin) 2(5): 363-372.
  22. Papageorgiou, I., Gournas, C., Vlanti, A., Amillis, S., Pantazopoulou, A. and Diallinas, G. (2008). Specific interdomain synergy in the UapA transporter determines its unique specificity for uric acid among NAT carriers. J Mol Biol 382(5): 1121-1135.
  23. Gournas, C., Papageorgiou, I. and Diallinas, G. (2008). The nucleobase-ascorbate transporter (NAT) family: genomics, evolution, structure-function relationships and physiological role. Mol Biosyst 4(5): 404-416.
  24. Vlanti, A. and Diallinas, G. (2008). The Aspergillus nidulans FcyB cytosine-purine scavenger is highly expressed during germination and in reproductive compartments and is downregulated by endocytosis. Mol Microbiol 68(4): 959-977.
  25. Papageorgiou, I., De Koning, H. P., Soteriadou, K. and Diallinas, G. (2008). Kinetic and mutational analysis of the Trypanosoma brucei NBT1 nucleobase transporter expressed in Saccharomyces cerevisiae reveals structural similarities between ENT and MFS transporters. Int J Parasitol 38(6): 641-653.
  26. Goudela, S., Reichard, U., Amillis, S. and Diallinas, G. (2008). Characterization and kinetics of the major purine transporters in Aspergillus fumigatus. Fungal Genet Biol 45(4): 459-472.

Chapters in books

  1. Diallinas, G. (2007). Aspergillus transporters. In “The Aspergilli: Genomics, Medicine, Biotechnology and Research Methods", Goldman, G. and Osmani, S. (eds). CRC press.
  2. Diallinas, G. (2004). Molecular Modeling of the Interactions of a Purine Transporter with Different Substrate Analogues: A first Step towards the Systematic Development of Antifungal Drugs. Review of Clinical Pharmacology and Pharmacokinetics, International Edition 18 (1), pp. 59.
  3. Tavoularis, S. N., Tazebay, U., Diallinas, G., Scazzocchio, C., Sophianopoulou, V. (1997). Preliminary studies on structure-function analysis of a major proline transporter (PRNB) of the filamentous fungus Aspergillus nidulans. Amino Acids 13 (1), pp. 31.
  4. Diallinas, G. and Kanellis, A. K. (1995). Developmntal and ripening regulation of gene expression of phenylpropanoid biosynthetic enzymes in melon fruit. Post-harvest physiology, pathology and technologies for horticultural commodities: Recent Advances. A.Ait-Oubahou abd El-Otmani (eds). 353-360.
  5. Felenbok, B., Sophianopoulou, V., Mathieu, M., Sequeval, D., Kulmburg, P., Diallinas, G. and Scazzocchio, C. (1989). Regulation of genes involved in the utilisation of carbon sources in Aspergillus nidulans. Procceedings of the EMBO-Alko Workshop on Molecular Biology of Filamentous Fungi, Helsinki 1989, Nevalainen and Pentilla. (eds). Foundation for Biotechnical and Industrial Fermentation Research, 6: 73-83.
Protocols by George Diallinas
  1. Transport Assays in Aspergillus nidulans