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Jose M. Frade


Ph.D. in Biology, Autonomous University of Madrid, 1994

Current position

Senior Researcher, Department of Molecular, Cellular and Developmental Neurobiology, Cajal Institute, Madrid, Spain

Publications (since 2005)

  1. Lopez-Sanchez, N., Ovejero-Benito, M. C., Rodríguez-Ruiz, C., Frade, J. M. (2013). NGF/p75NTR in cell cycle and neuronal tetraploidy. En: The Handbook of Neurotoxicity1st Edition Richard Kostrzewa (eds). Springer Verlag, Heidelberg In press
  2. Lopez-Sanchez, N. and Frade, J. M. (2013). Genetic evidence for p75NTR-dependent tetraploidy in cortical projection neurons from adult mice. J Neurosci 33(17): 7488-7500. (IF= 6.908)
  3. Ovejero-Benito, M. C. and Frade, J. M. (2013). Brain-derived neurotrophic factor-dependent cdk1 inhibition prevents G2/M progression in differentiating tetraploid neurons. PLoS One 8(5): e64890. (IF= 3.730)
  4. Formosa-Jordan, P., Ibanes, M., Ares, S. and Frade, J. M. (2013). Lateral inhibition and neurogenesis: novel aspects in motion. Int J Dev Biol 57(5): 341-350. (IF= 2.614)
  5. Morillo, S. M., Abanto, E. P., Roman, M. J. and Frade, J. M. (2012). Nerve growth factor-induced cell cycle reentry in newborn neurons is triggered by p38MAPK-dependent E2F4 phosphorylation. Mol Cell Biol 32(14): 2722-2737. (IF= 5.372)
  6. Formosa-Jordan, P., Ibanes, M., Ares, S. and Frade, J. M. (2012). Regulation of neuronal differentiation at the neurogenic wavefront. Development 139(13): 2321-2329. (IF= 6.208)
  7. Santos, A. M., Lopez-Sanchez, N., Martin-Oliva, D., de la Villa, P., Cuadros, M. A. and Frade, J. M. (2012). Sortilin participates in light-dependent photoreceptor degeneration in vivo. PLoS One 7(4): e36243. (IF= 3.730)
  8. Garcia-Dominguez, D. J., Morello, D., Cisneros, E., Kontoyiannis, D. L. and Frade, J. M. (2011). Stabilization of Dll1 mRNA by Elavl1/HuR in neuroepithelial cells undergoing mitosis. Mol Biol Cell 22(8): 1227-1239. (IF= 4.803)
  9. Lopez-Sanchez, N., Ovejero-Benito, M. C., Borreguero, L. and Frade, J. M. (2011). Control of neuronal ploidy during vertebrate development. Results Probl Cell Differ 53: 547-563.
  10. Nikoletopoulou, V., Lickert, H., Frade, J. M., Rencurel, C., Giallonardo, P., Zhang, L., Bibel, M. and Barde, Y. A. (2010). Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature 467(7311): 59-63. (IF= 38.597)
  11. Morillo, S. M., Escoll, P., de la Hera, A. and Frade, J. M. (2010). Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor. Proc Natl Acad Sci U S A 107(1): 109-114. (IF= 9.737)
  12. Frade, J. M. and Lopez-Sanchez, N. (2010). A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75NTR. Cell Cycle 9(10): 1934-1941. (IF= 5.321)
  13. Frade, J. M. (2010). Somatic tetraploidy in vertebrate neurons: Implications in physiology and pathology. Commun Integr Biol 3(2): 201-203.
  14. Latasa, M. J., Cisneros, E. and Frade, J. M. (2009). Cell cycle control of Notch signaling and the functional regionalization of the neuroepithelium during vertebrate neurogenesis. Int J Dev Biol 53(7): 895-908. (IF= 2.614)
  15. Cisneros, E., Latasa, M. J., Garcia-Flores, M. and Frade, J. M. (2008). Instability of Notch1 and Delta1 mRNAs and reduced Notch activity in vertebrate neuroepithelial cells undergoing S-phase. Mol Cell Neurosci 37(4): 820-831. (IF= 3.837)
  16. Morillo, S. M., Frade, J. M. (2008). Nerve growth factor signaling in neural cancer and metastasis. En: Nerve Growth Factor: New Research 1st Edition Guy K. McIntire. (eds). NOVA Science Publishers, Inc., New York.
  17. Lopez-Sanchez, N., Gonzalez-Fernandez, Z., Niinobe, M., Yoshikawa, K. and Frade, J. M. (2007). Single mage gene in the chicken genome encodes CMage, a protein with functional similarities to mammalian type II Mage proteins. Physiol Genomics 30(2): 156-171. (IF= 2.806)
  18. Lopez-Sanchez, N., Rodriguez, J. R. and Frade, J. M. (2007). Mitochondrial c-Jun NH2-terminal kinase prevents the accumulation of reactive oxygen species and reduces necrotic damage in neural tumor cells that lack trophic support. Mol Cancer Res 5(1): 47-60. [Cover caption] (IF= 4.353)
  19. Frade, J. M. (2006). Type II MAGE proteins at the crossroads of cell death and neurogenesis. En: Trends in Signal Transduction Research1st Edition. Jennifer N. Meyers. (eds). NOVA Science Publishers, New York.
  20. Frade, J. M. (2005). Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding. J Neurosci 25(6): 1407-1411. (IF= 6.908)
  21. Lopez-Sanchez, N., Muller, U. and Frade, J. M. (2005). Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein. Neuroscience 130(1): 51-60.. (IF= 3.122)

Protocols by Jose M. Frade
  1. Cell Cycle Analysis in the Vertebrate Brain Using Immunolabeled Fresh Cell Nuclei