Education

Master degree, University of Padua, Padua, 2013

Current position

PhD student, Department of Biomedical Sciences of Padua, University of Padua, Padua

Publications

1. Pirazzini, M., Azarnia Tehran, D., Zanetti, G., Rossetto, O. and Montecucco, C. (2017). Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals. Toxicon.
   
2. Zanetti, G., Sikorra, S., Rummel, A., Krez, N., Duregotti, E., Negro, S., Henke, T., Rossetto, O., Binz, T. and Pirazzini, M. (2017). Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission. PLoS Pathog 13(8): e1006567.
   
3. Bondi, M., Germinario, E., Pirazzini, M., Zanetti, G., Cencetti, F., Donati, C., Gorza, L., Betto, R., Bruni, P. and Danieli-Betto, D. (2017). Ablation of S1P3 receptor protects mouse soleus from age-related drop in muscle mass, force, and regenerative capacity. Am J Physiol Cell Physiol 313(1): C54-C67.
   
4. Azarnia Tehran, D., Zanetti, G., Leka, O., Lista, F., Fillo, S., Binz, T., Shone, C. C., Rossetto, O., Montecucco, C., Paradisi, C., Mattarei, A. and Pirazzini, M. (2015). A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins. Sci Rep 5: 17513.
   
5. Duregotti, E., Zanetti, G., Scorzeto, M., Megighian, A., Montecucco, C., Pirazzini, M. and Rigoni, M. (2015). Snake and Spider Toxins Induce a Rapid Recovery of Function of Botulinum Neurotoxin Paralysed Neuromuscular Junction. Toxins (Basel) 7(12): 5322-5336.
   
6. Zanetti, G., Azarnia Tehran, D., Pirazzini, M., Binz, T., Shone, C. C., Fillo, S., Lista, F., Rossetto, O. and Montecucco, C. (2015). Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism. Biochem Pharmacol 98(3): 522-530.
   
7. Pirazzini, M., Azarnia Tehran, D., Leka, O., Zanetti, G., Rossetto, O. and Montecucco, C. (2016). On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments. Biochim Biophys Acta 1858(3): 467-474.
   
8. Pirazzini, M., Azarnia Tehran, D., Zanetti, G., Lista, F., Binz, T., Shone, C. C., Rossetto, O. and Montecucco, C. (2015). The thioredoxin reductase--Thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles. Toxicon 107(Pt A): 32-36.
   
9. Pirazzini, M., Azarnia Tehran, D., Zanetti, G., Megighian, A., Scorzeto, M., Fillo, S., Shone, C. C., Binz, T., Rossetto, O., Lista, F. and Montecucco, C. (2014). Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins. Cell Rep 8(6): 1870-1878.