Education
Ph.D. in Molecular Immunology and Molecular Virology, Institute of Microbiology/Graduate School in Chinese Academy of Sciences (CAS), Beijing, China, 2007
Current position
Professor at Center for Infection & Immunity, Department of Medical Microbiology & Parasitology, Zhejiang University School of Medicine, 2014
Publications (since 2005)
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Shi, Z., Xuan, C., Han, H., Cheng, X., Wang, J., Feng, Y., Srinivas, S., Lu, G. and Gao, G. F. (2014). Gluconate 5-dehydrogenase (Ga5DH) participates in Streptococcus suis cell division. Protein & cell: 1-9.
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Feng, Y. and Cronan, J. E. (2014). PdhR, the pyruvate dehydrogenase repressor, does not regulate lipoic acid synthesis. Res Microbiol 165(6): 429-438.
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Feng, Y.*, Zhang, H., Wu, Z., Wang, S., Cao, M., Hu, D. and Wang, C. (2014). Streptococcus suis infection: an emerging/reemerging challenge of bacterial infectious diseases? Virulence 5(4): 477-497. (*Corresponding author)
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Hu, D., Zhang, F., Zhang, H., Hao, L., Gong, X., Geng, M., Cao, M., Zheng, F., Zhu, J., Pan, X., Tang, J., Feng, Y.* and Wang, C.* (2014). The beta-galactosidase (BgaC) of the zoonotic pathogen Streptococcus suis is a surface protein without the involvement of bacterial virulence. Sci Rep 4: 4140. (*Corresponding author)
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Yang, W., Lian, J., Feng, Y., Srinivas, S., Guo, Z., Zhong, H., Zhuang, Z. and Wang, S. (2014). Genome-wide miRNA-profiling of aflatoxin B1-induced hepatic injury using deep sequencing. Toxicology Letters 226(2): 140-149.
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Feng, Y., Napier, B. A., Manandhar, M., Henke, S. K., Weiss, D. S. and Cronan, J. E. (2014). A Francisella virulence factor catalyses an essential reaction of biotin synthesis. Mol Microbiol 91(2): 300-314.
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Zhang, J.#, Feng, Y.#, Hu, D., Lv, H., Zhu, J., Cao, M., Zheng, F., Zhu, J., Gong, X., Hao, L., Srinivas, S., Ren, H., Qi, Z., Li, B. and Wang, C. (2013). Rapid and sensitive detection of H7N9 avian influenza virus by use of reverse transcription-loop-mediated isothermal amplification. J Clin Microbiol 51(11): 3760-3764. (#Co-first author)
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Liu, H., Srinivas, S., He, X., Gong, G., Dai, C., Feng, Y.*, Chen, X.* and Wang, S.* (2013). Quorum Sensing in Vibrio and its Relevance to Bacterial Virulence. J Bacteriol Parasitol 4(172): 2. (*Corresponding author)
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Goble, A. M.#, Feng, Y.#, Raushel, F. M. and Cronan, J. E. (2013). Discovery of a cAMP deaminase that quenches cyclic AMP-dependent regulation. ACS Chem Biol 8(12): 2622-2629. (#Co-first author)
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Feng, Y.*, Xu, J., Zhang, H., Chen, Z. and Srinivas, S. (2013). Brucella BioR regulator defines a complex regulatory mechanism for bacterial biotin metabolism. J Bacteriol 195(15): 3451-3467. (*Corresponding author)
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Fang, Y., Feng, Y., Wu, T., Srinivas, S., Yang, W., Fan, J., Yang, C. and Wang, S. (2013). Aflatoxin B1 negatively regulates Wnt/beta-catenin signaling pathway through activating miR-33a. PLoS One 8(8): e73004.
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Wang, R., Xiang, S., Feng, Y., Srinivas, S., Zhang, Y., Lin, M. and Wang, S. (2013). Engineering production of functional scFv antibody in E. coli by co-expressing the molecule chaperone Skp. Front Cell Infect Microbiol 3: 72.
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Biswas, R. K., Dutta, D., Tripathi, A., Feng, Y., Banerjee, M. and Singh, B. N. (2013). Identification and characterization of Rv0494: a fatty acid-responsive protein of the GntR/FadR family from Mycobacterium tuberculosis. Microbiology 159(Pt 5): 913-923.
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Feng, Y., Zhang, H. and Cronan, J. E. (2013). Profligate biotin synthesis in alpha-proteobacteria - a developing or degenerating regulatory system? Mol Microbiol 88(1): 77-92.
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Wang, J., Wang, F., Feng, Y., Mi, K., Chen, Q., Shang, J. and Chen, B. (2013). Comparative vesicle proteomics reveals selective regulation of protein expression in chestnut blight fungus by a hypovirus. J Proteomics 78: 221-230.
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Feng, Y. and Cronan, J. E. (2012). Crosstalk of Escherichia coli FadR with global regulators in expression of fatty acid transport genes. PLoS One 7(9): e46275.
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Feng, Y., Zhang, H., Cao, M. and Wang, C. (2012). Regulation of virulence in Streptococcus suis. J Bacteriol Parasitol 3: e108. (*Corresponding author)
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Feng, Y., Cao, M., Shi, J., Zhang, H., Hu, D., Zhu, J., Zhang, X., Geng, M., Zheng, F., Pan, X., Li, X., Hu, F., Tang, J. and Wang, C. (2012). Attenuation of Streptococcus suis virulence by the alteration of bacterial surface architecture. Sci Rep 2: 710.
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Bi, H., Christensen, Q. H., Feng, Y., Wang, H. and Cronan, J. E. (2012). The Burkholderia cenocepacia BDSF quorum sensing fatty acid is synthesized by a bifunctional crotonase homologue having both dehydratase and thioesterase activities. Mol Microbiol 83(4): 840-855.
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Feng, Y., Cao, M., Wu, Z., Chu, F. and Ma, Y. (2011). Streptococcus suis in Omics-Era: Where Do We Stand. J Bacteriol Parasitol S2-001. doi 10: 2155-9597. (*Corresponding author)
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Cao, M., Feng, Y., Wang, C., Zheng, F., Li, M., Liao, H., Mao, Y., Pan, X., Wang, J., Hu, D., Hu, F. and Tang, J. (2011). Functional definition of LuxS, an autoinducer-2 (AI-2) synthase and its role in full virulence of Streptococcus suis serotype 2. J Microbiol 49(6): 1000-1011.
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Peng, H., Feng, Y., Zhu, X., Lan, X., Tang, M., Wang, J., Dong, H. and Chen, B. (2011). MoDUO1, a Duo1-like gene, is required for full virulence of the rice blast fungus Magnaporthe oryzae. Curr Genet 57(6): 409-420.
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Feng, Y. and Cronan, J. E. (2011). The Vibrio cholerae fatty acid regulatory protein, FadR, represses transcription of plsB, the gene encoding the first enzyme of membrane phospholipid biosynthesis. Mol Microbiol 81(4): 1020-1033.
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Liu, J., Dai, L., Qi, J., Gao, F., Feng, Y., Liu, W., Yan, J. and Gao, G. F. (2011). Diverse peptide presentation of rhesus macaque major histocompatibility complex class I Mamu-A 02 revealed by two peptide complex structures and insights into immune escape of simian immunodeficiency virus. J Virol 85(14): 7372-7383.
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Feng, Y. and Cronan, J. E. (2011). Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters. Mol Microbiol 80(1): 195-218.
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Zheng, F., Ji, H., Cao, M., Wang, C., Feng, Y., Li, M., Pan, X., Wang, J., Qin, Y., Hu, F. and Tang, J. (2011). Contribution of the Rgg transcription regulator to metabolism and virulence of Streptococcus suis serotype 2. Infect Immun 79(3): 1319-1328.
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Feng, Y. and Cronan, J. E. (2010). Overlapping repressor binding sites result in additive regulation of Escherichia coli FadH by FadR and ArcA. J Bacteriol 192(17): 4289-4299.
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Feng, Y., Zhang, H., Ma, Y. and Gao, G. F. (2010). Uncovering newly emerging variants of Streptococcus suis, an important zoonotic agent. Trends Microbiol 18(3): 124-131.
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Yi, Y., Ma, Y., Gao, F., Mao, X., Peng, H., Feng, Y., Fan, Z., Wang, G., Guo, G., Yan, J., Zeng, H., Zou, Q. and Gao, G. F. (2010). Crystal structure of EHEC intimin: insights into the complementarity between EPEC and EHEC. PLoS One 5(12): e15285.
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Feng, Y. and Cronan, J. E. (2009). A new member of the Escherichia coli fad regulon: transcriptional regulation of fadM (ybaW). J Bacteriol 191(20): 6320-6328.
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Feng, Y. and Cronan, J. E. (2009). Escherichia coli unsaturated fatty acid synthesis: complex transcription of the fabA gene and in vivo identification of the essential reaction catalyzed by FabB. J Biol Chem 284(43): 29526-29535.
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Feng, Y., Pan, X., Sun, W., Wang, C., Zhang, H., Li, X., Ma, Y., Shao, Z., Ge, J., Zheng, F., Gao, G. F. and Tang, J. (2009). Streptococcus suis enolase functions as a protective antigen displayed on the bacterial cell surface. J Infect Dis 200(10): 1583-1592.
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Feng, Y., Shi, X., Zhang, H., Zhang, S., Ma, Y., Zheng, B., Han, H., Lan, Q., Tang, J., Cheng, J., Gao, G. F. and Hu, Q. (2009). Recurrence of human Streptococcus suis infections in 2007: three cases of meningitis and implications that heterogeneous S. suis 2 circulates in China. Zoonoses Public Health 56(9-10): 506-514.
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Ge, J.#, Feng, Y.#, Ji, H., Zhang, H., Zheng, F., Wang, C., Yin, Z., Pan, X. and Tang, J. (2009). Inactivation of dipeptidyl peptidase IV attenuates the virulence of Streptococcus suis serotype 2 that causes streptococcal toxic shock syndrome. Curr Microbiol 59(3): 248-255. (#Co-first author).
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Cheng, Y.#, Feng, Y.#, Luo, P., Gu, J., Yu, S., Zhang, W. J., Liu, Y. Q., Wang, Q. X., Zou, Q. M. and Mao, X. H. (2009). Fusion expression and immunogenicity of EHEC EspA-Stx2Al protein: implications for the vaccine development. J Microbiol 47(4): 498-505. (#Co-first author).
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Ma, Y., Feng, Y., Liu, D. and Gao, G. F. (2009). Avian influenza virus, Streptococcus suis serotype 2, severe acute respiratory syndrome-coronavirus and beyond: molecular epidemiology, ecology and the situation in China. Philos Trans R Soc Lond B Biol Sci 364(1530): 2725-2737.
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Wang, C., Li, M., Feng, Y., Zheng, F., Dong, Y., Pan, X., Cheng, G., Dong, R., Hu, D., Feng, X., Ge, J., Liu, D., Wang, J., Cao, M., Hu, F. and Tang, J. (2009). The involvement of sortase A in high virulence of STSS-causing Streptococcus suis serotype 2. Arch Microbiol 191(1): 23-33.
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Tian, X., Lu, G., Gao, F., Peng, H., Feng, Y., Ma, G., Bartlam, M., Tian, K., Yan, J., Hilgenfeld, R. and Gao, G. F. (2009). Structure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). J Mol Biol 392(4): 977-993.
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Pan, X., Ge, J., Li, M., Wu, B., Wang, C., Wang, J., Feng, Y., Yin, Z., Zheng, F., Cheng, G., Sun, W., Ji, H., Hu, D., Shi, P., Feng, X., Hao, X., Dong, R., Hu, F. and Tang, J. (2009). The orphan response regulator CovR: a globally negative modulator of virulence in Streptococcus suis serotype 2. J Bacteriol 191(8): 2601-2612.
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Feng, Y., Li, M., Zhang, H., Zheng, B., Han, H., Wang, C., Yan, J., Tang, J. and Gao, G. F. (2008). Functional definition and global regulation of Zur, a zinc uptake regulator in a Streptococcus suis serotype 2 strain causing streptococcal toxic shock syndrome. J Bacteriol 190(22): 7567-7578.
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Feng, Y., Zhao, T., Nguyen, T., Inui, K., Ma, Y., Nguyen, T. H., Nguyen, V. C., Liu, D., Bui, Q. A., To, L. T., Wang, C., Tian, K. and Gao, G. F. (2008). Porcine respiratory and reproductive syndrome virus variants, Vietnam and China, 2007. Emerg Infect Dis 14(11): 1774-1776.
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Li, M.#, Wang, C.#, Feng, Y.#, Pan, X., Cheng, G., Wang, J., Ge, J., Zheng, F., Cao, M., Dong, Y., Liu, D., Wang, J., Lin, Y., Du, H., Gao, G. F., Wang, X., Hu, F. and Tang, J. (2008). SalK/SalR, a two-component signal transduction system, is essential for full virulence of highly invasive Streptococcus suis serotype 2. PLoS One 3(5): e2080. (#Co-first author)
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Khan, A. H., Chu, F., Feng, Y., Zhang, Q., Qi, J. and Gao, G. F. (2008). Crystallization and preliminary crystallographic analysis of recombinant immunoglobulin G-binding protein from Streptococcus suis. Acta Crystallogr Sect F Struct Biol Cryst Commun 64(Pt 8): 757-759.
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Guo, Y., Guo, G., Mao, X., Zhang, W., Xiao, J., Tong, W., Liu, T., Xiao, B., Liu, X., Feng, Y. and Zou, Q. (2008). Functional identification of HugZ, a heme oxygenase from Helicobacter pylori. BMC Microbiol 8: 226.
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Ma, Y., Mao, X., Li, J., Li, H., Feng, Y., Chen, H., Luo, P., Gu, J., Yu, S., Zeng, H., Guo, G., Yang, K. and Zou, Q. (2008). Engineering an anti-Stx2 antibody to control severe infections of EHEC O157:H7. Immunol Lett 121(2): 110-115.
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Wang, G., Zhan, D., Li, L., Lei, F., Liu, B., Liu, D., Xiao, H., Feng, Y., Li, J., Yang, B., Yin, Z., Song, X., Zhu, X., Cong, Y., Pu, J., Wang, J., Liu, J., Gao, G. F. and Zhu, Q. (2008). H5N1 avian influenza re-emergence of Lake Qinghai: phylogenetic and antigenic analyses of the newly isolated viruses and roles of migratory birds in virus circulation. J Gen Virol 89(Pt 3): 697-702.
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Feng, Y., Zheng, F., Pan, X., Sun, W., Wang, C., Dong, Y., Ju, A. P., Ge, J., Liu, D., Liu, C., Yan, J., Tang, J. and Gao, G. F. (2007). Existence and characterization of allelic variants of Sao, a newly identified surface protein from Streptococcus suis. FEMS Microbiol Lett 275(1): 80-88.
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Feng, Y. and Gao, G. F. (2007). Towards our understanding of SARS-CoV, an emerging and devastating but quickly conquered virus. Comp Immunol Microbiol Infect Dis 30(5-6): 309-327.
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Chen, C.#, Tang, J.#, Dong, W.#, Wang, C.#, Feng, Y.#, Wang, J., Zheng, F., Pan, X., Liu, D., Li, M., Song, Y., Zhu, X., Sun, H., Feng, T., Guo, Z., Ju, A., Ge, J., Dong, Y., Sun, W., Jiang, Y., Wang, J., Yan, J., Yang, H., Wang, X., Gao, G. F., Yang, R., Wang, J. and Yu, J. (2007). A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates. PLoS One 2(3): e315. (#Co-first author)
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Tian, X., Feng, Y., Zhao, T., Peng, H., Yan, J., Qi, J., Jiang, F., Tian, K. and Gao, F. (2007). Molecular cloning, expression, purification and crystallographic analysis of PRRSV 3CL protease. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 63(8): 720-722.
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Tian, K., Yu, X., Zhao, T., Feng, Y., Cao, Z., Wang, C., Hu, Y., Chen, X., Hu, D., Tian, X., Liu, D., Zhang, S., Deng, X., Ding, Y., Yang, L., Zhang, Y., Xiao, H., Qiao, M., Wang, B., Hou, L., Wang, X., Yang, X., Kang, L., Sun, M., Jin, P., Wang, S., Kitamura, Y., Yan, J. and Gao, G. F. (2007). Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS One 2(6): e526.
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Feng, Y., Qi, J., Zhang, H., Wang, J., Liu, J., Jiang, F. and Gao, F. (2006). X-ray crystallographic characterization of rhesus macaque MHC Mamu-A*02 complexed with an immunodominant SIV-Gag nonapeptide. Acta Crystallogr Sect F Struct Biol Cryst Commun 62(Pt 1): 13-15.
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Tang, J.#, Wang, C.#, Feng, Y.#, Yang, W., Song, H., Chen, Z., Yu, H., Pan, X., Zhou, X. and Wang, H. (2006). Streptococcal toxic shock syndrome caused by Streptococcus suis serotype 2. PLoS Medicine 3(5): e151. (#Co-first author)
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Liu, C.#, Feng, Y.#, Gao, F., Zhang, Q. and Wang, M. (2006). Characterization of HCoV-229E fusion core: implications for structure basis of coronavirus membrane fusion. Biochem Biophys Res Commun 345(3): 1108-1115. (#Co-first author)
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Ma, G.#, Feng, Y.#, Gao, F., Wang, J., Liu, C. and Li, Y. (2005). Biochemical and biophysical characterization of the transmissible gastroenteritis coronavirus fusion core. Biochem Biophys Res Commun 337(4): 1301-1307. (#Co-first author)
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Liu, J., Xiao, H., Lei, F., Zhu, Q., Qin, K., Zhang, X. W., Zhang, X. L., Zhao, D., Wang, G., Feng, Y., Ma, J., Liu, W., Wang, J. and Gao, G. F. (2005). Highly pathogenic H5N1 influenza virus infection in migratory birds. Science 309(5738): 1206.
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Cheng, H., Jiang, N., Shen, A. and Feng, Y. (2005). Molecular cloning and functional expression of d-arabitol dehydrogenase gene from Gluconobacter oxydans in Escherichia coli. FEMS Microbiol Lett 252(1): 35-42.