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Coauthors
Stefan Kubicek CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
1 protocol

Sara Sdelci
  • CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
  • 1 Author merit

Education

Ph.D in Dr. Roig’s group at IRB (Institute of Research in Biomedicine), Barcelona, 2012 Thesis title: Role of the Kinases Nek6, Nek7 and Nek9 in the Regulation of Centrosome Cycle
Supervisor: Dr. Joan Roig
Grade: summa cum laude

Current position

Postdoc in Dr. Kubicek’s group at CeMM (Center for Molecular Medicine of the Austria Academy of Science), Vienna

Publications

  1. Licciardello, M. P., Ringler, A., Markt, P., Klepsch, F., Lardeau, C. H., Sdelci, S., Schirghuber, E., Muller, A. C., Caldera, M., Wagner, A., Herzog, R., Penz, T., Schuster, M., Boidol, B., Durnberger, G., Folkvaljon, Y., Stattin, P., Ivanov, V., Colinge, J., Bock, C., Kratochwill, K., Menche, J., Bennett, K. L. and Kubicek, S. (2017). A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor. Nat Chem Biol 13(7): 771-778.
  2. Li, J., Casteels, T., Frogne, T., Ingvorsen, C., Honore, C., Courtney, M., Huber, K. V., Schmitner, N., Kimmel, R. A., Romanov, R. A., Sturtzel, C., Lardeau, C. H., Klughammer, J., Farlik, M., Sdelci, S., Vieira, A., Avolio, F., Briand, F., Baburin, I., Majek, P., Pauler, F. M., Penz, T., Stukalov, A., Gridling, M., Parapatics, K., Barbieux, C., Berishvili, E., Spittler, A., Colinge, J., Bennett, K. L., Hering, S., Sulpice, T., Bock, C., Distel, M., Harkany, T., Meyer, D., Superti-Furga, G., Collombat, P., Hecksher-Sorensen, J. and Kubicek, S. (2017). Artemisinins Target GABAA Receptor Signaling and Impair alpha Cell Identity. Cell 168(1-2): 86-100 e115.
  3. Sdelci, S., Lardeau, C. H., Tallant, C., Klepsch, F., Klaiber, B., Bennett, J., Rathert, P., Schuster, M., Penz, T., Fedorov, O., Superti-Furga, G., Bock, C., Zuber, J., Huber, K. V., Knapp, S., Muller, S. and Kubicek, S. (2016). Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk. Nat Chem Biol 12(7): 504-510.
  4. Licciardello, M. P., Mullner, M. K., Durnberger, G., Kerzendorfer, C., Boidol, B., Trefzer, C., Sdelci, S., Berg, T., Penz, T., Schuster, M., Bock, C., Kralovics, R., Superti-Furga, G., Colinge, J., Nijman, S. M. and Kubicek, S. (2015). NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation. Oncogene 34(29): 3780-3790.
  5. Sdelci, S., Schutz, M., Pinyol, R., Bertran, M. T., Regue, L., Caelles, C., Vernos, I. and Roig, J. (2012). Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of gamma-tubulin recruitment to the mitotic centrosome. Curr Biol 22(16): 1516-1523.
  6. Sdelci, S., Bertran, M. T. and Roig, J. (2011). Nek9, Nek6, Nek7 and the separation of centrosomes. Cell Cycle 10(22): 3816-3817.
  7. Bertran, M. T., Sdelci, S., Regue, L., Avruch, J., Caelles, C. and Roig, J. (2011). Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J 30(13): 2634-2647.
  8. Regue, L., Sdelci, S., Bertran, M. T., Caelles, C., Reverter, D. and Roig, J. (2011). DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9. J Biol Chem 286(20): 18118-18129.
  9. Cellai, C., Laurenzana, A., Bianchi, E., Sdelci, S., Manfredini, R., Vannucchi, A. M., Caporale, R., Balliu, M., Mannelli, F., Ferrari, S., Bosi, A., Miniati, D., Cocco, P. L., Veronneau, S., Stankova, J. and Paoletti, F. (2009). Mechanistic insight into WEB-2170-induced apoptosis in human acute myelogenous leukemia cells: the crucial role of PTEN. Exp Hematol 37(10): 1176-1185 e1121.
  10. Rovida, E., Spinelli, E., Sdelci, S., Barbetti, V., Morandi, A., Giuntoli, S. and Dello Sbarba, P. (2008). ERK5/BMK1 is indispensable for optimal colony-stimulating factor 1 (CSF-1)-induced proliferation in macrophages in a Src-dependent fashion. J Immunol 180(6): 4166-4172.
1 Protocol published
Generation of a Cellular Reporter for Functional BRD4 Inhibition
Authors:  Sara Sdelci and Stefan Kubicek, date: 07/05/2017, view: 982, Q&A: 0
The ubiquitously expressed bromodomain-containing protein 4 (BRD4) is an epigenetic reader, which recruits transcriptional regulatory complexes to acetylated chromatin. Because of its role in enhancing proliferation, BRD4 has become a therapeutic ...