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Coauthors
Fred Naider Department of Chemistry and Macromolecular Assembly Institute, College of Staten Island of the City University of New York, USA
2 protocols

Houjian Cai University of Georgia
2 protocols

Melinda Hauser Department of Microbiology, University of Tennessee, USA
2 protocols

Jeffrey M. Becker
  • Department of Microbiology, University of Tennessee, USA
Contributions
  • 2 Author merit

Education

Ph.D. in Microbiology, University of Cincinnati, 1970        

Current Position

Chancellor’s Professor Emeritus, Department of Microbiology, University of Tennessee, Knoxville, TN, USA

Publications

  1. Perry, J. R., Basrai, M. A., Steiner, H. Y., Naider, F. and Becker, J. M. (1994). Isolation and characterization of a Saccharomyces cerevisiae peptide transport gene. Mol Cell Biol 14(1): 104-115.
  2. Steiner, H. Y., Song, W., Zhang, L., Naider, F., Becker, J. M. and Stacey, G. (1994). An Arabidopsis peptide transporter is a member of a new class of membrane transport proteins. Plant Cell 6(9): 1289-1299.
  3. Barnes, D., Lai, W., Breslav, M., Naider, F. and Becker, J. M. (1998). PTR3, a novel gene mediating amino acid-inducible regulation of peptide transport in Saccharomyces cerevisiae. Mol Microbiol 29(1): 297-310.
  4. Cai, H., Hauser, M., Naider, F. and Becker, J. M. (2007). Differential regulation and substrate preferences in two peptide transporters of Saccharomyces cerevisiae. Eukaryot Cell 6(10): 1805-1813.
  5. Lichliter, W. D., Naider, F. and Becker, J. M. (1976). Basis for the design of anticandidal agents from studies of peptide utilization in Canadida albicans. Antimicrob Agents Chemother 10(3): 483-490.
  6. Steinfeld, A. S., Naider, F. and Becker, J. M. (1979). Anticandidal activity of 5-fluorocytosine-peptide conjugates. J Med Chem 22(9): 1104-1109.
  7. Lubkowitz, M. A., Hauser, L., Breslav, M., Naider, F. and Becker, J. M. (1997). An oligopeptide transport gene from Candida albicans. Microbiology 143 ( Pt 2): 387-396.
  8. Bulawa, C. E., Miller, D. W., Henry, L. K. and Becker, J. M. (1995). Attenuated virulence of chitin-deficient mutants of Candida albicans. Proc Natl Acad Sci U S A 92(23): 10570-10574.
  9. Gale, C. A., Bendel, C. M., McClellan, M., Hauser, M., Becker, J. M., Berman, J. and Hostetter, M. K. (1998). Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1. Science 279(5355): 1355-1358.
  10. Roemer, T., Jiang, B., Davison, J., Ketela, T., Veillette, K., Breton, A., Tandia, F., Linteau, A., Sillaots, S., Marta, C., Martel, N., Veronneau, S., Lemieux, S., Kauffman, S., Becker, J., Storms, R., Boone, C. and Bussey, H. (2003). Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol Microbiol 50(1): 167-181.
  11. Becker, J. M., Kauffman, S. J., Hauser, M., Huang, L., Lin, M., Sillaots, S., Jiang, B., Xu, D. and Roemer, T. (2010). Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model. Proc Natl Acad Sci U S A 107(51): 22044-22049.
  12. Naider, F. and Becker, J. M. (1986). Structure-activity relationships of the yeast alpha-factor. CRC Crit Rev Biochem 21(3): 225-248.
  13. Huang, L. Y., Umanah, G., Hauser, M., Son, C., Arshava, B., Naider, F. and Becker, J. M. (2008). Unnatural amino acid replacement in a yeast G protein-coupled receptor in its native environment. Biochemistry 47(20): 5638-5648.
  14. Umanah, G. K., Huang, L., Ding, F. X., Arshava, B., Farley, A. R., Link, A. J., Naider, F. and Becker, J. M. (2010). Identification of residue-to-residue contact between a peptide ligand and its G protein-coupled receptor using periodate-mediated dihydroxyphenylalanine cross-linking and mass spectrometry. J Biol Chem 285(50): 39425-39436.
  15. Rymer, J. K., Hauser, M., Bourdon, A. K., Campagna, S. R., Naider, F. and Becker, J. M. (2015). Novobiocin and peptide analogs of alpha-factor are positive allosteric modulators of the yeast G protein-coupled receptor Ste2p. Biochim Biophys Acta 1848(4): 916-924.
2 Protocols published
Uptake Assay for Radiolabeled Peptides in Yeast
Authors:  Melinda Hauser, Houjian Cai, Fred Naider and Jeffrey M. Becker, date: 11/20/2016, view: 1872, Q&A: 0
We describe an assay for measuring the uptake of radioactive peptides into the yeast Saccharomyces cerevisiae. The methods presented here can be adapted to measure a variety of substrates transported into any bacterial or fungal cell via ...
Halo Assay for Toxic Peptides and Other Compounds in Microorganisms
Authors:  Houjian Cai, Melinda Hauser, Fred Naider and Jeffrey M. Becker, date: 11/20/2016, view: 1942, Q&A: 0
We describe an assay for determination of toxicity in S. cerevisiae involving spotting of a toxic peptide on a lawn of yeast cells. This assay may be generalized to determine toxicity of a variety of compounds by substituting a putative ...