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Coauthors
Bruce Beutler Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, USA
1 protocol

Anne Murray Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, USA
1 protocol

Hexin Shi
  • Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, USA
Contributions
  • 1 Author merit

Education

Ph.D. in Biochemistry and molecular biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China

Current position

Instructor, Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A

Publications

  1. Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M., Berger, M., Zhan, X., Zhang, H., Boger, D. L. and Beutler, B. (2016). TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proc Natl Acad Sci U S A 113(7): E884-893.

  2. Shi, H., Wang, Y., Li, X., Zhan, X., Tang, M., Fina, M., Su, L., Pratt, D., Bu, C. H., Hildebrand, S., Lyon, S., Scott, L., Quan, J., Sun, Q., Russell, J., Arnett, S., Jurek, P., Chen, D., Kravchenko, V. V., Mathison, J. C., Moresco, E. M., Monson, N. L., Ulevitch, R. J. and Beutler, B. (2016). NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol 17(3): 250-258.

  3. Wang, T., Zhan, X., Bu, C. H., Lyon, S., Pratt, D., Hildebrand, S., Choi, J. H., Zhang, Z., Zeng, M., Wang, K. W., Turer, E., Chen, Z., Zhang, D., Yue, T., Wang, Y., Shi, H., Wang, J., Sun, L., SoRelle, J., McAlpine, W., Hutchins, N., Zhan, X., Fina, M., Gobert, R., Quan, J., Kreutzer, M., Arnett, S., Hawkins, K., Leach, A., Tate, C., Daniel, C., Reyna, C., Prince, L., Davis, S., Purrington, J., Bearden, R., Weatherly, J., White, D., Russell, J., Sun, Q., Tang, M., Li, X., Scott, L., Moresco, E. M., McInerney, G. M., Karlsson Hedestam, G. B., Xie, Y. and Beutler, B. (2015). Real-time resolution of point mutations that cause phenovariance in mice. Proc Natl Acad Sci U S A 112(5): E440-449.

  4. Zeng, M., Hu, Z., Shi, X., Li, X., Zhan, X., Li, X. D., Wang, J., Choi, J. H., Wang, K. W., Purrington, T., Tang, M., Fina, M., DeBerardinis, R. J., Moresco, E. M., Pedersen, G., McInerney, G. M., Karlsson Hedestam, G. B., Chen, Z. J. and Beutler, B. (2014). MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses. Science 346(6216): 1486-1492.

  5. Siggs, O. M., Xiao, N., Wang, Y., Shi, H., Tomisato, W., Li, X., Xia, Y. and Beutler, B. (2012). iRhom2 is required for the secretion of mouse TNFalpha. Blood 119(24): 5769-5771.

1 Protocol published
Reconstruction of the Mouse Inflammasome System in HEK293T Cells
Authors:  Hexin Shi, Anne Murray and Bruce Beutler, date: 11/05/2016, view: 1866, Q&A: 0
The NLRP3 (NLR family, Pyrin domain containing 3) inflammasome is a multiprotein complex comprised of NLRP3, pro-caspase-1, the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC), and the protein kinase NIMA related ...